I take topomax 100mg in a.m. and 100mg in p.m. . I don't have migranes but it is also used for mood disorders which i have. I don't have any wierd side affects but there is a side affect of weight loss I have heard about. I have lost weight but I'm not sure if its because of the topamax. I have been on it for at least 6 months or more. My son 11 takes it also. I don't get headaches that often though. Don't know if its because of the med or not. And I do have a pharmacy of my own too! That's why I'm kina leery of starting new meds for fibro. I know I need something to help me but ANOTHER PILL??? But I guess you gotta do what you gotta do.