Question about Melatonin

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Sera Smiles
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Date Joined Nov 2006
Total Posts : 671
   Posted 8/13/2008 9:25 PM (GMT -7)   
I have recently [a couple of months now] began taking 3 mg of Melatonin at night and have just last week increased to 5mg. A woman at the GNC told me not to take more than that because Melatonin is a hormone and I can do harm to myself by increasing again. I think its is helping with sleep, it just doesn't work as quickly as I would like. Can anyone here tell me more about that?  I have read lots of threads on this but still have questions about the issue of it being a hormone and being harmful in some doses. Thank you!
DX- FMS 2003; Hypertension; Depression; PTSD; IBS
 
RX- Ultram 100mg x 2/d; Toprol 100mg/d; Cymbalta 60mg/d; Buspar 5mg x 2/d;  Malic / Magn 1650/300 x 2/d; Claritin 10mg/d; Bendryl 50mg x 2/d;
B-Complex 1/d; Melatonin 5mg/night; Ginseng 500mg x 2/d
 
PRN- Flexeril 10mg; Hyoscine Butyl 2 mg
 
 
"Its never too late to be who you might have been" George Eliot


Ms. Tify
Regular Member


Date Joined Apr 2008
Total Posts : 70
   Posted 8/14/2008 4:02 AM (GMT -7)   

Just my two cents, but if the melatonin is not working for you, then you don't need it.  That is why you are not noticing a difference when you take it. 

You might want to try something else to help you sleep.  Some people swear by Valerian, have you ever tried it?  I had to use an RX for awhile, just to get my body used to sleeping again.


here's all my issues:  fibromyalgia, osteoarthritis, pinched nerve in neck, high blood pressure, sleep disorder, Raynaud's disease, food allergies,
("but you don't look sick!")
 
what I take:  three different meds for high blood pressure, vitamins, magnesium and calcium. 
 
**slightly confused, all of the time!**


ericsmom
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Date Joined Jan 2007
Total Posts : 1042
   Posted 8/14/2008 5:25 AM (GMT -7)   
Good Morning Sera
 
Yep..I tried the Melatonin not long ago.  I was having a prolonged RLS and insomnia episode that lasted for days. In desperation I went out and got myslelf some melatonin...took 3 mg first night, 6 the second...and 9 on my last attempt.  Like you, it took forever to work (if it even did)
 
MsTify probably hit the nail on the head when she said it didnt work because that wasnt the problem.  I went back to the doctor and got a new RX for Xanax, and from that night on, I am able to sleep fairly well, and the RLS has subsided.
 
Did 9 mg change my hormone levels?...I guess I would have to ask hubby that question tongue
 
Hugs, Diane
Fibromyagia, R/A, Diabetes, Atrial Fib, depression

folic acid, metformin, diamicron, bisoprolol, fenofibrate, pantoloc, wellbutrin, propafenone, ibprofen, warfarin, methotrexate


Some people dream of angels, I held one in my arms


Dagger
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Date Joined Apr 2008
Total Posts : 1522
   Posted 8/14/2008 7:05 PM (GMT -7)   
I've noticed that my sleep has been even worse than usual for the past few months and I've been thinking about melotonin so I did a little research.

Melatonin is a hormone secreted by the pineal gland in the brain that helps regulate other hormones and maintains the body's circadian rhythm. Melatonin also helps control the timing and release of female reproductive hormones.

There are no known serious side effects to regulated melatonin supplementation. Some people may experience vivid dreams or nightmares. Overuse or incorrect use of melatonin could disrupt circadian rhythms. Long-term effects have not been well studied. In rats, melatonin decreases T4 and T3 uptake levels.

Melatonin can cause drowsiness if taken during the day. If morning drowsiness is experienced after taking melatonin at night, reduce dosage levels. In some cases of depression, daytime doses of melatonin can increase depression.

May be contraindicated for those with autoimmune disorders and immune system cancers (e.g., lymphoma, leukemia).

Because melatonin suppresses corticosteroid activity, those who are taking corticosteroids for anti-inflammatory or immune suppressive purposes (e.g., transplant patients) should exercise caution with melatonin supplementation.

Melatonin could interfere with fertility. It is also contraindicated during pregnancy and lactation.

Individuals who experience orthostatic intolerance, a cardiovascular condition that results in reduced blood pressure and blood flow to the brain when a person stands, may experience a worsening of symptoms when taking melatonins supplements. Some fibro people also have orthostatic intolerance so be aware of this side effect.

Some common medications affect melotonin levels. I read that certain high blood pressure meds can reduce melotonin including the one I started a few months ago. I knew it was probably responsible but now I know how.

Sera Smiles
Veteran Member


Date Joined Nov 2006
Total Posts : 671
   Posted 8/14/2008 8:08 PM (GMT -7)   
Thank you all for your thoughts, I appreciate your talking with me about this. Dagger- can I ask what blood pressure med you are on? I am on toprol, and I am not thrilled at the thought of it reducing the amount of melatonin I have in my system. Tify, I did buy some valerian, but dang it smelled so nasty! I couldn't make myself take it, altho I have been assured [by people who have nevber taken it LOL] that it won't repeat on me all through the day with that icky gross smell. What were your experiences with valerian and its smell?
Peace!
DX- FMS 2003; Hypertension; Depression; PTSD; IBS
 
RX- Ultram 100mg x 2/d; Toprol 100mg/d; Cymbalta 60mg/d; Buspar 5mg x 2/d;  Malic / Magn 1650/300 x 2/d; Claritin 10mg/d; Bendryl 50mg x 2/d;
B-Complex 1/d; Melatonin 5mg/night; Ginseng 500mg x 2/d
 
PRN- Flexeril 10mg; Hyoscine Butyl 2 mg
 
 
"Its never too late to be who you might have been" George Eliot


Dagger
Veteran Member


Date Joined Apr 2008
Total Posts : 1522
   Posted 8/16/2008 8:04 PM (GMT -7)   
I'm on amlodipine. I'll see if I can find the list of blood pressure meds that reduce melatonin.

Valerian has to be one of the worst smelling things I've ever known a person to injest. I took it many years ago and I don't remember a problem with it. It was in capsule form. My husband was drinking Valerian tea for a while but I made him stop, I couldn't take the smell.

Dagger
Veteran Member


Date Joined Apr 2008
Total Posts : 1522
   Posted 8/16/2008 8:13 PM (GMT -7)   
I found this on the University of Maryland Medical Center's website:

Melatonin may reduce the effectiveness of blood pressure medications like methoxamine and clonidine. In addition, medications in a class called calcium channel blockers (such as nifedipine, verapamil, diltiazem, amlodipine, nimodipine, felodipine, nisoldipine, and bepridil) may decrease melatonin levels.

Use of Beta-Blockers (another class of high blood pressure medications including propranolol, acebutolol, atenolol, labetolol, metoprolol, pindolol, nadolol, sotalol, and timolol) may reduce melatonin production in the body.

Sera Smiles
Veteran Member


Date Joined Nov 2006
Total Posts : 671
   Posted 8/17/2008 12:10 PM (GMT -7)   
Thats good information about BP meds, thank you Dagger. I do take Metoprolol [Toprol generic] in the morning only, and I take melatonin around 10p. I will rethink the valerian, I am curious if it might work. At this point I am open to anything that has a known high rating of ickiness.
Peace!
DX- FMS 2003; Hypertension; Depression; PTSD; IBS
 
RX- Ultram 100mg x 2/d; Toprol 100mg/d; Cymbalta 60mg/d; Buspar 5mg x 2/d;  Malic / Magn 1650/300 x 2/d; Claritin 10mg/d; Bendryl 50mg x 2/d;
B-Complex 1/d; Melatonin 5mg/night; Ginseng 500mg x 2/d
 
PRN- Flexeril 10mg; Hyoscine Butyl 2 mg
 
 
"Its never too late to be who you might have been" George Eliot


papasgirl
Regular Member


Date Joined Apr 2007
Total Posts : 44
   Posted 8/17/2008 1:34 PM (GMT -7)   
hi there
 
 I have been reading thru this post and it was very informational. I just recently tried melatonin but it didnt work for me so i stopped taking it and now im taking benadryl,my dad takes it and swears by it and my stepmother had bad nightmares so i guess it depends on your body. I had some left over of mine that i gave to my stepson as he has trouble sleeping also he is taking 9mg at about 10 pm and is getting the drowsiness in the morning. Im now wondering with the hormone thing and he is 24 if he should be taking it or not i didnt realize that effect on people. I guess i will have to tell him the side effects and let him decide. If anyone has any ideas on what else he could possibly take it would be appreciated. He cant take prescription meds so ativan and xanax and such is out of the question, he needs something "all natural" i guess. thank you for any help u can give me.                                           papasgirl :-) tongue
fibro,arthritis,many spinal problems,herniated disk,bone spurs,muscle spasms,chronic neck and low back pain,chronic fatigue,anxiety,panic attacks,depression ect...... hahaha i think its enough now!!!
 
meds: percocet,ativan,lodine,protonix,cymbalta and benadryl


alicat72
Regular Member


Date Joined Jun 2008
Total Posts : 79
   Posted 8/17/2008 7:29 PM (GMT -7)   
melatonin is normally produced by the body's pineal gland. as we get older, we do not produce as much melatonin. the pineal gland is part of the endocrine system and therefore produces a hormone (as does the pancreas produce insulin...the adrenal glands produce adrenaline....ect)

melatonin is also a very powerful antioxidant. i have actually seen people buy large stores of it to combat the anthrax spore (god forbid that we are ever exposed). i would certainly never take more than 6mgs/night....you really shouldn't have to. sometimes less is more ya know? whenever i take more than 25mgs of benadryl, i am restless, but just 25 mgs puts me to sleep pretty quick.

ps. never give melatonin to a child skull not that you would, just so ya'll know...

solar powered
Veteran Member


Date Joined Nov 2007
Total Posts : 538
   Posted 8/18/2008 8:53 AM (GMT -7)   
I had asked my sleep specialsist about melatonin and he told me that he had a patient once who took it without dr supervision and that it screwed up her hormone levels so badly that it took nearly 2 years to get them normalized. Needless to say, he didn't think that was a good option to explore. Lisa

d2parrotperson
Regular Member


Date Joined Aug 2008
Total Posts : 320
   Posted 8/18/2008 11:22 AM (GMT -7)   
Sera Smiles. Melatonin should be taken carefully. Valerian is a wonder herb! It stinks horribly, but does not repeat (lol)!! Taking it in pill ofrm is very helpful. Another way to take it is in Celestial Seasonings Sleepy Time Extra Tea. Awesome stuff! It tastes, and smells wonderful. One more thign though; NEVER take Valerian if you are taking LYRICA!!!!!
150mg Azathioprine
Lomotil
Iron
Nexium 2/day
Fentanyl patch
Oxycodone
Baclofin
 
Crohn's, Fibromyalgia, Several bad discs, bone spurs, Osteoarthritis, Osteopenia, Reflux, Stenosis, Stricture
2 resections
 
Stephanie
 
When I am weak, then am I strong


Sera Smiles
Veteran Member


Date Joined Nov 2006
Total Posts : 671
   Posted 8/18/2008 2:32 PM (GMT -7)   
Hey Parrot person! Thanks for your input- how much Valerian should I take for sleep?
DX- FMS 2003; Hypertension; Depression; PTSD; IBS
 
RX- Ultram 100mg x 2/d; Toprol 100mg/d; Cymbalta 60mg/d; Buspar 5mg x 2/d;  Malic / Magn 1650/300 x 2/d; Claritin 10mg/d; Bendryl 50mg x 2/d;
B-Complex 1/d; Melatonin 5mg/night; Ginseng 500mg x 2/d
 
PRN- Flexeril 10mg; Hyoscine Butyl 2 mg
 
 
"Its never too late to be who you might have been" George Eliot


d2parrotperson
Regular Member


Date Joined Aug 2008
Total Posts : 320
   Posted 8/18/2008 2:35 PM (GMT -7)   
The dosage is right on the bottle~! You're welcome BTW.
150mg Azathioprine
Lomotil
Iron
Nexium 2/day
Fentanyl patch
Oxycodone
Baclofin
 
Crohn's, Fibromyalgia, Several bad discs, bone spurs, Osteoarthritis, Osteopenia, Reflux, Stenosis, Stricture
2 resections
 
Stephanie
 
When I am weak, then am I strong

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