Savella- New FDA approved drug for FM

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TeNNiSd0C09
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Date Joined Jul 2007
Total Posts : 1303
   Posted 1/20/2009 2:20 PM (GMT -7)   
I heard that this was a new drug approved by the FDA for Fibro... I was wondering if any of you had heard of it or anything... although, its not expected to be in pharmacies until March.. I just read about it being announced!

This is what I read:

FDA Approves Savella for Fibromyalgia January, 2009

Savella (milnacipran hydrochloride) has been approved by the U.S. Food and Drug Administration to treat fibromyalgia, a chronic condition characterized by restricted movement and widespread pain, makers Forest Labs and Cypress Bioscience announced.

The safety and effectiveness of the drug, a selective serotonin and norepinephrine dual reuptake inhibitor, were established in clinical trials involving 2,084 patients. In a news release, the drug’s makers said it’s not known exactly how Savella improves symptoms of fibromyalgia, which some scientists believe is related to abnormalities in certain brain neurotransmitters.

As many as 6 million Americans have fibromyalgia, making it the second-most common condition diagnosed in rheumatology clinics behind osteoarthritis, the companies said. There is no cure.

Savella is expected in pharmacies by March.
Common side effects reported during clinical testing included constipation, hot flushes, vomiting, heart palpitations, dry mouth, and a rise in blood pressure

Any thoughts?

What about switching? For example, I take Lyrica. I believe it has caused weight gain..It helps some, but not as much as I wish..should I consider switching like in the summer when I dont have school or anything going on? Plus, I must consider that I've been on Lyrica for over a year..but Im worried about how long I can stay on it at the same time... There was shown more tolerance of Savella.. and I didnt read anything about weight gain, which is good. This makes me wonder and question though... We shall wait and see if anyone on here will take it/or does take it.... honestly, this is the first time I've heard of it so... thoughts?
Lyrica and Paxil (both working quite well might I add!)
   "Cracks in the concrete are just reminders that you fall apart no matter how strong you are"
    "Sometimes it is best to forget what you feel and remember what you deserve"
    "Im going to smile like nothing is wrong, talk like everything is perfect, act like its all a dream, and pretend its not hurting me."

Post Edited (TeNNiSd0C09) : 1/20/2009 2:27:33 PM (GMT-7)


getting by
Forum Moderator


Date Joined Sep 2007
Total Posts : 40572
   Posted 1/20/2009 2:30 PM (GMT -7)   
Wow Christi,

That really is great. I hope that it works.

This is really good news, thanks for the information!!!

Hugs, Karen
  Moderator-Depression and fibromyalgia
 
fibromyalgia, Chronic fatigue, depression,allergies


TeNNiSd0C09
Veteran Member


Date Joined Jul 2007
Total Posts : 1303
   Posted 1/20/2009 2:35 PM (GMT -7)   
It has shown that it worked well in the trials..so hopefully this will provide some hope for those who have had trouble taking Lyrica and such... At least this allows us to see that there are people out there who are still searching and trying to help those with FM! Its slightly reassuring!

And, your welcome! Its really good news!
Lyrica and Paxil (both working quite well might I add!)
   "Cracks in the concrete are just reminders that you fall apart no matter how strong you are"
    "Sometimes it is best to forget what you feel and remember what you deserve"
    "Im going to smile like nothing is wrong, talk like everything is perfect, act like its all a dream, and pretend its not hurting me."


Dagger
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Date Joined Apr 2008
Total Posts : 1522
   Posted 1/20/2009 2:41 PM (GMT -7)   
I was in a clinical study for milnacipran a few years ago. I had severe hot flushes, heart palpitations, increased resting heart rate (120 bpm) and a large rise in blood pressure. I had to drop out of the study. I noticed a slight decrease in pain and a little more energy but no where near enough improvement to tolerate the side effects. It did not effect my fibrofog at all.

I know a few other people that were in the study. One woman was on the placebo, she didn't notice anything. Two other women dropped out due to the heart palpitations and rise in blood pressure. One had very low blood pressure to start.

For one friend, it gave him his life back. It reduced his pain to a tolerable level and cut his fatigue enough so that he could go back to teaching one class a week. He gets to stay on it for a few years now for free.

One of our support group members was a pharmacist and he told us how to tell if we were taking the placebo so we all knew.

The dosages used in the study seemed high so I am hoping lower dosages are used in practice. This may keep the side effects to a minimum. I would suggest that anyone who tries it monitors their blood pressure frequently for the first few months.

TeNNiSd0C09
Veteran Member


Date Joined Jul 2007
Total Posts : 1303
   Posted 1/20/2009 7:10 PM (GMT -7)   
Thank you for the information! Thanks for sharing, very helpful!
Lyrica and Paxil (both working quite well might I add!)
   "Cracks in the concrete are just reminders that you fall apart no matter how strong you are"
    "Sometimes it is best to forget what you feel and remember what you deserve"
    "Im going to smile like nothing is wrong, talk like everything is perfect, act like its all a dream, and pretend its not hurting me."

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