Some of the older OTC pain meds like percogesic and even Pamprin used to be a mixture of Tylenol and aspirin...and caffeine. I have taken Tylenol and Advil together but now I stagger them...every couple of hours. Advil is murder on my stomach and I try to avoid it but sometimes I'd rather have the burning throat than the pain!
I stagger them. I keep them at least three hours apart. When I take ibuprofen, I have to take three (600 mg) for them to work. Then if needed, three hours later, I will take two extra strength Tylenol.