Hello Highlights. I have been on xyrem for almost 3 years to improve my sleep problems due to fibro. It has been very helpful to me. I usually wake up and feel rested but not groggy. From what I understand you do not build a tolerance to it. There are nights that I don't take it because I eat dinner too late (need to take on empty stomach) and don't have any adverse effects. There are possible side effects which are listed on their website www.xyrem.com but I think they are dosage related, at least they were for me. I take 1/2 (1 1/2 grams) of the lowest recommended dose and have no side effects. I did take a higher dose when I first started since it is trial and error and it was too strong for me, I couldn't walk. In an emergency that would be an issue so dropped it down which seems to do the trick for me. Since I am sleeping better my pain level is down and my energy level is up. I wasn't on any meds for fibro so can't say if it will help enough to be able to stop any meds. The instructions say to take split doses during the night even if you have to set an alarm to take the second one but my sleep dr said that wasn't necessary. Probably the biggest downside to it is the cost. If you are thinking about trying it check with your insurance beforehand because it costs over $700 a bottle (1 month supply at lowest recommended dose) and not all insurance will cover it. I had tried a few other sleep meds but they either didn't work very well or gave me side effects that weren't tolerable. Xyrem has been a very good med for me. I think it helps kind of reset things sleep wise also because I now sleep better on the nights I don't take it then I did before I started taking it, if that makes sense. Oh one suggestion, if you do take it mix it with diet sprite or any diet soda without caffeine. It tastes terrible when just mixed with water. The soda was my dr's idea. Good luck if you try it and just ask if you have anymore questions. I might be able to help. Lisa
If I can laugh at it, I can live with it.