Hi, Rhonda! It's okay to just vent. As I recall, you have autoimmune hepatitis, which is why you are on the Imuran and were on prednisone. I'm fatigued all the time from hep C, so I can relate to that. And I can tell you that the side effects from prednisone are awful, including osteonecrosis (bone death) of the large joints, requiring joint replacement, and also stress fractures of the spine. So I hope you will be able to tolerate the Imuran.
"But that was yesterday, and I was a different person then."
Alice in Wonderland, Lewis Carroll