how would you exclude those in end stage liver failure vs. those with AoCLF?

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mwl
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Date Joined Feb 2010
Total Posts : 1
   Posted 2/9/2010 7:58 AM (GMT -7)   
How to classify patient in end stage liver failure or those with AoCLF?

hep93
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Date Joined Jul 2005
Total Posts : 12014
   Posted 2/9/2010 10:11 AM (GMT -7)   

Mwl, welcome to the forum.  I'm not quite sure what you are asking.  What is AoCLF?  Some type of chronic liver failure, I'm assuming.  Do you mean how do you differentiate between the two?  Could you give a little more info/background.

Thanks!

Connie


hep93
Forum moderator - Hepatitis
 
"But that was yesterday, and I was a different person then."
Lewis Carroll, Alice in Wonderland


DGinSD
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Date Joined Apr 2007
Total Posts : 839
   Posted 2/9/2010 12:30 PM (GMT -7)   

Acute-on-chronic liver failure: pathophysiological basis of therapeutic options.

Jalan R, Williams R.

Institute of Hepatology, University College, London Medical School and UCL Hospitals, London, UK. r.jalan@ucl.ac.uk

The vast majority of patients that are referred to a specialist hepatological centre suffer from acute deterioration of their chronic liver disease. Yet, this entity of acute-on-chronic liver failure remains poorly defined. With the emergence of newer liver support strategies, it has become necessary to define this entity, its pathophysiology and the short- and long-term prognosis. This review focusses upon how a precipitant such as an episode of gastrointestinal bleeding or sepsis may start a cascade of events that culminate in end-organ dysfunction and liver failure. We briefly review the pathophysiological basis of the therapeutic modalities that are available. Our current strategy for the management of liver failure involves supportive therapy for the end-organs with the hope that liver function would recover if sufficient time for such a recovery is allowed. Because liver failure, whether of the acute or acute-on-chronic variety, is potentially reversible, the stage is set for the application of newer liver-support strategies to enhance the recovery process. Copyright 2002 S. Karger AG, Basel

Hi Connie, 

This is what I found online.  I guess it's a new description to differentiate how someone has gotten to ESLD?

 

 


Dany
 
Diagnosed with AIH January 2007,
CMV (cytomegalovirus) June 2008
meds: Azathioprine 100mg
 
 


hep93
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Date Joined Jul 2005
Total Posts : 12014
   Posted 2/9/2010 3:45 PM (GMT -7)   

Thanks, Dany. 

To the original poster, I guess the first would be someone whose liver has been deteriorating over time until they got to ESLD, and the second would be someone who was okay but then had an acute event which precipitated rapid deterioration to ESLD.

Hugs,

Connie


hep93
Forum moderator - Hepatitis
 
"But that was yesterday, and I was a different person then."
Lewis Carroll, Alice in Wonderland

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