News on a non interferon based Hep C treatment

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MamaLama
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Date Joined Oct 2010
Total Posts : 3992
   Posted 7/11/2011 12:12 PM (GMT -7)   
Saw this news release today:
 
Medivir: TMC435 Has Received Fast Track Designation From The FDA And TMC435 Will Be Studied In Combination With Pharmasset's PSI-7977 For HCV

Medivir AB (OMX: MVIR), is an emerging research-based specialty pharmaceutical company focused on infectious diseases...

To read the full article, please go to:
http://www.medicalnewstoday.com/releases/230777.php


hep93
Elite Member


Date Joined Jul 2005
Total Posts : 12014
   Posted 7/11/2011 2:16 PM (GMT -7)   

Major find, ML!  Thanks!!  FINALLY a company is ready to study a hep C treatment that doesn't include interferon!  While this may not be available to post-transplant patients, it will help an awful lot of patients who can't tolerate interferon.

Hugs,

Connie


hep93
Forum moderator - Hepatitis


"But that was yesterday, and I was a different person then."

Lewis Carroll, Alice in Wonderland

Kimlp2
Regular Member


Date Joined Jun 2011
Total Posts : 23
   Posted 7/13/2011 2:17 PM (GMT -7)   
THANK YOU! As Connie said it was a great find! Although it may not be available for post-transplant currently, I am sure it will emerge someday.
Kim

MamaLama
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Date Joined Oct 2010
Total Posts : 3992
   Posted 7/13/2011 3:02 PM (GMT -7)   
Mike was a non responder genotype 1a in 2003.

He was in a study that looked at dosages of ribavarin and interferon at that time. He was not a SVR! :-(

His Doc told him NO MORE INTERFERON. Ever.

He waited 8 years for a non-interferon based treatment, but needed a transplant before every happened.

And now we are at the same juncture again. New liver, 15,500,000 viral load...and no post trasplant protocol for the new treatements.

I wonder if he'll volunteer for a trial again.

That's to be seen.

He sees the Hepatologist on August 4th for preliminary discussions about a traditional treatment. He dreads the conversation. Though others are having some luck this time. The post transplant surgeon told us that SVR (sustained viral response) is still only seen at 25% or so with post transplant regimes...same as before I think!

Mama Lama

mer
Veteran Member


Date Joined Aug 2008
Total Posts : 613
   Posted 7/13/2011 3:24 PM (GMT -7)   
ML,

What a great find!!! My hubby is one that cannot tolerate interferon and so for the last 6-7 years he basically has just been sitting around with NO treatment, checking bloodword and scans to make sure not tumors growing.

Waiting on a phone call back from the coordinator, as they are scheduling his colonoscopy/endoscopy as we speak and also scheduling our appt with his hepatologist. Would LOVE to have the conversation with her about these new treatments coming out and what she has to say about it!

Mer

hep93
Elite Member


Date Joined Jul 2005
Total Posts : 12014
   Posted 7/13/2011 5:07 PM (GMT -7)   

Mer, can you go with him to the appt. with the hepatologist?  If so, run it by the doc.  Can't hurt and you possibly can gain some info.

Carol, that astounds me that Mike's viral load is so high.  I have heard that after transplant the C can return with a vengeance.  Hardly seems fair.  The  highest my viral load has been is what it is currently:  68,000.  With the new cancer, it went up from 38,000.  So I don't think that viral load is truly indicative of what is going on.  But I may have the same experience post transplant.

My brief experience, when interferon alone was the only treatment, wasn't good.  I, too, have been hoping for a treatment w/o interferon.  However, I was planning on trying the Incivek (with the protease inhibitor.)  Two months before it became available the end of May, I was diagnosed with HCC again.  So I'm now just waiting to be listed for transplant, with no idea of what treatment I'll be offered post transplant...but suspecting it will be "the combo," since there's no data of how the newer drugs affect transplant patients.

But for those just diagnosed or who haven't yet transplanted--the newer drugs offer hope for better clearance.  It remains to be seen what the clearance rate will be with the non-interferon treatment, though.

Hugs,

Connie



hep93
Forum moderator - Hepatitis


"But that was yesterday, and I was a different person then."

Lewis Carroll, Alice in Wonderland

Post Edited (hep93) : 7/13/2011 7:13:55 PM (GMT-6)


**David**
Veteran Member


Date Joined Nov 2009
Total Posts : 3382
   Posted 7/13/2011 5:51 PM (GMT -7)   
I'm into my ninth month of interferon/ribavirin therapy. I did it before in 2004. Then, I had a high dose of both drugs and was sick the entire 48 weeks. I had a transplant in 2009 and last fall, my viral load started climbing, so I chose to go back on the therapy. This time, my doses are a third less and other than a couple of weeks, almost no problems. My doctors were pleased that it took a year, post transplant to have the viral load start to rise. Usually, it happens soon after a transplant, when your body is weakened and you've started anti rejection meds. Two months ago, at the transplant clinic, Incivek was brought up to me. I said it wasn't being used on transplant patients and my nurse practitioner said that MGH was about to start treating post transplant patients. Since I was already doing the interferon/ribavirin therapy, she said if my current treatment didn't work out, they might switch me to Incivek. Now, I'll ask them about the newest non interferon treatment, the next time I'm there. That will be mid September.
Have a nice day!

hep93
Elite Member


Date Joined Jul 2005
Total Posts : 12014
   Posted 7/13/2011 7:16 PM (GMT -7)   

Good to know, David!  My hep doc had also said something about my possibly still being able to get the Incivek post transplant, but I haven't put a lot of faith in that.

Hugs,

Connie


hep93
Forum moderator - Hepatitis


"But that was yesterday, and I was a different person then."

Lewis Carroll, Alice in Wonderland

mer
Veteran Member


Date Joined Aug 2008
Total Posts : 613
   Posted 7/13/2011 9:33 PM (GMT -7)   
Yes, I will be attending the appointment with him for the hepotologist appointment. I never send him to those on his own....alot of information, and he has memory issues as it is!!

Very interested to hear what she has to say. We have an amazing hepatologist, and I have complete trust that she will do whatever in his best interest

Mer

mer
Veteran Member


Date Joined Aug 2008
Total Posts : 613
   Posted 7/13/2011 9:35 PM (GMT -7)   
Oh, one other thing.....my brother in law had to go on the interferon/ribavarin treatment after his transplant, but it seems like it was several years before they detected a viral load on him. His transplant was due to alpha-1 antitrypson defeciency, not Hep C. But, his transplant was done before they started testing organs and blood products for Hep C, so the doc was thinking that he contracted it from transplant, but who knows. He did the treatment and has been fine since.

Mer
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