I also have read quite a bit about Mike Thistle and have been thinking about trying it for the last month my levels have been stable according to the doctor last month there were AST31 ALT 49 first time in eight months that they have been normal and close to normal last week they went up slightly to AST 40 ALT 58 doctor was not concerned said it is still stable but I am a little worried that they are on the way up again. Do any of you get this kind of rise in levels all the time and then do they ever stay at normal. I am currently on 20mg prednisone I was unable to take the Imuran and the doctors feel I should just stay on the prednisone and not mix it with any other medications until I achieve a true remission which they say is 6 months of normal stable levels. Then they want to repeat biopsy has anyone had a repeat biopsy to check on inflamation? My doctors do not think that Milk Thistle or anyone of the other over the counter drugs do anything for the liver but the book by Dr Melissa Palmer also suggests taking Mike Thistle and she is a renowned helatologist let me know if anyone has had any good results with Mike Thistle and if it lowered their levels. Thanks again for the support would be lost without this chat line.