#Article: Dynogen IBS treatment has good results in trial (IBS-D)

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Yowie
Regular Member


Date Joined May 2006
Total Posts : 91
   Posted 1/1/2008 4:25 PM (GMT -7)   
This looks really promising for us IBS-D sufferers. 71pc response rate vs 25pc placebo... seems pretty effective. Wonder what the mechanics of it are.





http://www.bizjournals.com/boston/stories/2007/12/17/daily1.html

Dynogen IBS treatment has good results in trial
Boston Business Journal


Anyone with stomach problems will want to read this story.

A new treatment for patients who suffer from irritable bowel syndrome with diarrhea has generated promising results in a mid-stage human clinical trial.

The drug, developed by Waltham, Mass.-based Dynogen Pharmaceuticals Inc., generated a statistically significant response rate involving 87 women at multiple sites in the United States and Canada.

Over the eight-week trial, a one milligram-dose of DDP225 achieved a 71 percent response rate in helping give patients relief of IBS pain and discomfort, versus a 25 percent response rate for placebo.

The drug will likely advance to Phase III clinical trials, the last phase of testing to be completed before a drug can be submitted for federal regulatory approval.

Dynogen's positive data is good news for people who suffer from irritable bowel syndrome, which affects about 27 million people in the United States alone.

The condition involves abdominal pain and discomfort as well as diarrhea.
DX'd with Fructose Malabsorbtion Dec 2006
DX'd with IBS May 2006

Current Medications :
None, but occasionally carry Seirogan for fast relief from D.

www.irritablebowelsyndrome-info.com/


Yowie
Regular Member


Date Joined May 2006
Total Posts : 91
   Posted 1/1/2008 4:32 PM (GMT -7)   
More info..

about DDP225

DDP225 is an oral noradrenaline reuptake inhibitor (NARI) and a weak 5HT3 receptor antagonist that Dynogen is developing for IBS-d. Noradrenaline and serotonin are neurotransmitters that are known to be involved in the control of the gastrointestinal system. The unique combination of noradrenaline reuptake inhibition and weak 5HT3 antagonism in one orally delivered compound represents a novel approach to treating IBS-d, enabling efficacy to be achieved at very low and well tolerated doses of DDP225. Dynogen licensed preclinical and clinical data related to DDP225 from Mitsubishi Tanabe Pharma in October 2003. It has been dosed to over 450 human subjects for durations up to 12 weeks, and at single doses up to 100 mg. Dynogen owns issued patents and pending patent applications related to the use of DDP225 as a treatment for IBS.

Post Edited By Moderator (Admin) : 3/10/2008 10:39:44 AM (GMT-6)


Sarita
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Date Joined Mar 2005
Total Posts : 2486
   Posted 1/3/2008 5:35 AM (GMT -7)   
This should be very interesting to follow up on...I was wondering when they'd come up with a neurotransmitter reuptake inhibitor designed specifically for IBS!
Co-moderator - IBS Forum


Yowie
Regular Member


Date Joined May 2006
Total Posts : 91
   Posted 1/3/2008 5:46 AM (GMT -7)   
wonder what the side effects of something like this could be? Can someone fill me on how NARI's work? Is it something like how Zyban worked with smokers?

Post Edited By Moderator (Admin) : 3/10/2008 10:39:32 AM (GMT-6)


Sarita
Veteran Member


Date Joined Mar 2005
Total Posts : 2486
   Posted 1/3/2008 6:33 AM (GMT -7)   
They've found that people with IBS tend to have decreased levels of available norepinephrine in the intestine, which is required for regular motility. By administering a noradrenaline (or norepinephrine)-reuptake inhibitor, more of that neurotransmitter will be available and, hopefully, that would help in regulating the contractility of the gut. It's kind of the same idea behind the selective serotonin reuptake inhibitors (SSRIs) like Prozac, Zoloft, etc. but with a different class of neurotransmitters.
Co-moderator - IBS Forum


Yowie
Regular Member


Date Joined May 2006
Total Posts : 91
   Posted 1/3/2008 2:31 PM (GMT -7)   
Ahh thanks for explaining that to me Sarita. Well i've emailed the company and asked them if they need participants for a phase-III clinical trial.

Post Edited By Moderator (Admin) : 3/10/2008 10:39:21 AM (GMT-6)

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