I forgot to mention one thing....if you are taking Amitiza for the first time my doctor told me to expect to have nausea for at least a couple of weeks and it should go away. ALWAYS take it 1/2 to 2/3 into eating a meal not a snack but a meal and that will help. I take it with about
16 oz of water to. I am not sure if that would help with the nausea but I believe the medication works best that way.