I have severe IBS-D and acid reflux disease and was put on Welchol 2 pills 3x a day, and pamine 2 pills 3x a day a week ago. havent noticed it helping yet and was wondering if any of you had tried these meds? i am also on ocella (birth control) for endometreosis, and aciphex for my reflux. ive also tried lomotil, levbid, bentyl, immodium, lialyda? a med for colitus, and prob a few others im not thinking of. I'm considering just going back to immodium again, but its effect varied day to day, and sometimes was not enouph on its own. the pamine is making me tired. i feel druged out. bentyl and lomotil did the same thing to me. i could sleep all day on these meds. dry mouth, nausia, stomach pain, extreme worseing of reflux, are all things im experiencing so far this week from these two new meds. fun fun.