Hey, Maxie! Nice to meet you. I took Amitiza for a little bit. I got samples from my doc and they were helping but I gave up when I realized my medical plan wouldn't cover them and they cost about three hundred dollars a month, or something like that. Since then I have been doing whatever I can over the counter. I am probably spending at least a third of that if not more on OTC things. I also thought Amitiza was making me go too often (if that is possible when you are constipated...but I always felt like I had to go.) At this point I really don't know what to do. I can induce D with bad-for-me food if I need to, but I hate doing that, because I know it is upsetting the IBS even more. I took Phillips Colon Health awhile ago and I remember it helping actually. I am thinking it might have helped more than the Align is helping me, but I might just be remembering things wrong at this point. I thought probiotics were my answer because they seemed to help me the most out of anything I have ever tried, but I think I am taxing this one too much. I was on a really strict diet back when I took Phillips (I also took Digestive Advantage for awhile and that seemed to help too.) I need to get back to my really strict almost no-fat diet for awhile because I know that is what helps the most so that my gut can heal itself. It's just really hard to face that. What do you eat that helps you?