I can tell you my experience with Align. I have had IBS-D for 27 years. I tried Align, completing 2 weeks of it. Within 12 days, I had (keeping record) 27 spells with my stomach. I told myself, although I had IBS-D really bad; that maybe it will take awhile to help. I was wrong and got discouraged one night. I emailed the company and told them what had happened while taking their product. They were shocked that it did that to me and suggested that I stop taking Align and save any other remaining pills. They sent my problem to the Health and Safety Department. Of course, this might not happen to eeryone; but that is what I experienced. I am now taking Caltrate for Bone and Colon Heath. 600+D plus with minerals, calcium supplement. I don't want to jinx myself, but I have improved some. Thanks to the person that had suggested it to me.