I cannot tell you how great I am doing. I have went from 5 times a day on good day to 10 times bad day to 20 times a day dont leave the house day TO ONE TIME A DAY!!!!!!! for the last 3 weeks, First time in 5 years I do not feel like I have to go all the time and I get relief when I go. I am on Savella for Fibro and it has also helped my IBS-D. So if anyone out there has Fibro and IBS-D it has really helped me. I feel like a new person and wanted to tell everyone how much it helped me. Take care all.