I have never personally taken it and there is some new info out on it I can get yet.
This is from their site.
"How should I take LOTRONEX?
Take LOTRONEX exactly as your doctor prescribes it. You can take LOTRONEX with or without food.
Begin with 0.5 mg two times a day for 4 weeks to see how LOTRONEX affects you. You and your doctor may decide that you should keep taking this dose if you are doing well.
Check with your doctor 4 weeks after starting LOTRONEX:
If you try 0.5 mg two times a day for 4 weeks, it may not control your symptoms. If you do not get constipation or other side effects from LOTRONEX, your doctor may increase your dose up to 1 mg two times a day.
If 1 mg two times a day does not work after 4 weeks, LOTRONEX is not likely to help you. You should stop taking it and call your doctor.
If you miss a dose of LOTRONEX, just skip that dose. Do not take 2 doses the next time. Wait until the next time you are supposed to take it and then take your normal dose.
Follow the important instructions in the section "What is the most important information I should know about LOTRONEX?" about when you must stop taking the drug and when you should call your doctor.
If you see other doctors about your IBS or side effects from LOTRONEX, let the doctor who prescribed LOTRONEX know."
I am not a doctor. All information I present is for educational purposes only and should not be subsituted for the advise of a qualified health care provider.
Please make sure you have your symptoms diagnosed by a medical practitioner or a doctor.