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NiRo
Regular Member


Date Joined Aug 2009
Total Posts : 198
   Posted 9/1/2010 5:01 PM (GMT -7)   
Wanted to get your take/view on this article...

http://www.prohealth.com/me-cfs/library/showArticle.cfm?libid=15566&B2=MSGBDART

Thanks!
Diagnosed with Pancolitis (Moderate in 4/5th of the colon, Mild in 1/5th) in July 2009
Lialda 4x a day (2x in the morning, 2x at night)
Rowasa Enema 3x a week (M,W,F)
Align (Probiotic) 1x a day
Fish Oil 4x a day
Multi-Vitamins (includes B-12, Vitamin D, Vitamin C) 1x a day
Life long vegetarian...

shawn12
Veteran Member


Date Joined Jul 2004
Total Posts : 1293
   Posted 9/2/2010 3:23 PM (GMT -7)   
I would not read to much into that yet. I am not sure Glutamine is goona help a ton at this point but who knows. There is a lot of research showing different areas that are messed up in IBS and this is new of course.
 
I ask an expert about it when it first came out.
 
Dr Drossman
 
"

Shawn,

My disclaimer is that basic science research is not my area of expertise so I can’t comment on the methodological rigor, only the results and I only glanced at the article.  We do know that intestinal permeability may play a role in the clinical expression of IBS. That is actually the basis for transmigration of bacterial products which sets the stage for submucosal inflammation and visceral sensitization.  This is where all the work on bacterial flora and probiotics come in: to destabilize or stabilize the gut mucosal barrier. These authors have demonstrated an association in IBS patients who have increased intestinal membrane permeability with a genetic marker for glutamine synthetase expression.  So there may a genetic linkage for a metabolic mechanism that leads to intestinal permeability which in turn may predispose to IBS development.

Doug

 

Hope that helps.

 

 

 


IBS Forum Moderator


I am not a doctor. All information I present is for educational purposes only and should not be subsituted for the advise of a qualified health care provider.

Please make sure you have your symptoms diagnosed by a medical practitioner or a doctor.

NiRo
Regular Member


Date Joined Aug 2009
Total Posts : 198
   Posted 9/8/2010 1:04 PM (GMT -7)   
Thanks Shawn. Sorry for the late response, I was in the bat cave trying and testing to see if it worked. I asked on this forum mainly as I have seen L-glutamine being referenced w/ IBS-D.

I was actually trying to "firm" up my stool as I weaned off the Donnatal. Well, I can safely say that the L-Glutamine has definitely helped. Everyone is different, but after taking roughly 10g for 3 days (5g 30 min before breakfast and dinner), stools have definitely firmed up. I am hoping that there is some healing of my intestinal cells that have been damaged from a bad UC flare over a year ago w/ the L-glutamine. But I think it mainly is working by making my large intestine absorb more water. I know it is probably symptomatic relief, but I'll take it.

I will probably try to lower my dose to half of what it is now. Anyhow, just wanted to send you my thanks and report back.
Diagnosed with Pancolitis (Moderate in 4/5th of the colon, Mild in 1/5th) in July 2009
Lialda 4x a day (2x in the morning, 2x at night)
Align (Probiotic) 1x a day + Culturelle (Probiotic) 1x a day
Fish Oil 2x a day
Vitamin D 5000 IU 1x a day
L-Glutamine 10g (5g 30 min. before meals 2x a day)
Rowasa 1x a day when necessary
Life long vegetarian...

shawn12
Veteran Member


Date Joined Jul 2004
Total Posts : 1293
   Posted 9/9/2010 9:54 AM (GMT -7)   
NiRo

That is interesting. I am glad to hear its helping. How did you come up with the dose?

Some probiotics have been shown to help repair damaged gut cells.

I hope it continues to work for you. let us know how it goes and you keep trying it.

Thanks for reporting back on this.
IBS Forum Moderator


I am not a doctor. All information I present is for educational purposes only and should not be subsituted for the advise of a qualified health care provider.

Please make sure you have your symptoms diagnosed by a medical practitioner or a doctor.

NiRo
Regular Member


Date Joined Aug 2009
Total Posts : 198
   Posted 9/9/2010 10:48 AM (GMT -7)   
Hi Shawn,

The dose was based on some posts from other members over on the UC board and various websites while I was researching effective doses. Some folks take doses as high as 30g, but I didn't want to go that crazy right away.
Diagnosed with Pancolitis (Moderate in 4/5th of the colon, Mild in 1/5th) in July 2009
Lialda 4x a day (2x in the morning, 2x at night)
Align (Probiotic) 1x a day + Culturelle (Probiotic) 1x a day
Fish Oil 2x a day
Vitamin D 5000 IU 1x a day
L-Glutamine 10g (5g 30 min. before meals 2x a day)
Rowasa 1x a day when necessary
Life long vegetarian...

shawn12
Veteran Member


Date Joined Jul 2004
Total Posts : 1293
   Posted 9/9/2010 11:18 AM (GMT -7)   
don't go to crazy right away. ;)
 
I think I have heard at to high a dose it can cause stomach upset.
 
 
IBS Forum Moderator


I am not a doctor. All information I present is for educational purposes only and should not be subsituted for the advise of a qualified health care provider.

Please make sure you have your symptoms diagnosed by a medical practitioner or a doctor.
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