Melatonin & Diarrhea???

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SusieQ5555
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Date Joined Feb 2014
Total Posts : 26
   Posted 2/17/2014 12:03 AM (GMT -6)   
Has anyone experienced loose watery stools with use of melatonin? I started taking 3 mg of melatonin about 3 months ago when I was experiencing insomnia after the death of my brother. It worked so well I continued to take it nightly rather than just "as needed." Then 6 weeks ago I started to have foul smelling, watery diarrhea 5-10 times a day. I became dehydrated & developed aching legs from electrolyte imbalance most likely, and knew enough to increase fluid intake which included electrolytes. Initially I took Imodium as the diarrhea was frequent, urgent, explosive & the cramping was quite uncomfortable. I could not leave the house. It did little to help so I stopped the Immodium thinking I might have a bowel infection. My Doctor ordered stool cultures, ova & parasite testing & even C-Difficile testing as I had been on an antibiotic for a respiratory infection. All tests were negative. I happened on a forum related to melatonin & the side effect of watery diarrhea many people had experienced. I was really surprised! It sounded identical to my own symptoms and in some cases people had even had colonoscopies after all stool tests came back negative. They had no answer to their problem until they stopped taking melatonin. I stopped taking melatonin 2 days ago. I am still having diarrhea but the cramping & urgency have stopped & I am down to 3 movements a day. I was on a BRAT diet but have eaten more normally in past 2 days. I have lost 8 lbs. People on the site reported a return to normal stools ranging from 2 days to 2 weeks. Although this natural hormone has many good traits, if it is indeed the cause of such severe diarrhea, It is shocking. It can make one very ill as well as affect quality of life significantly. This is a long time to have watery stools! Has anyone else experienced this side effect?

Post Edited (SusieQ5555) : 2/16/2014 11:33:05 PM (GMT-7)


Penelopekjh
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Date Joined Nov 2015
Total Posts : 1
   Posted 11/20/2015 9:13 AM (GMT -6)   
I absolutely had all the same symptoms. I just have one question. How long was it before the diarrhea went away completely?
Thanks

Sparky2000
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Date Joined Jan 2016
Total Posts : 1
   Posted 1/23/2016 10:54 AM (GMT -6)   
I usually don't post on social forums but when I found these posts I just had to respond! I too just discovered that melatonin has been the source of a month-long bout with chronic diarrhea. I had been taking the gummy chewables for months and they seemed to really help me sleep. I ran out so I bought another bottle and when I got home I discovered that I had bought a different brand. Not sure if this is where my troubles began or if I had just reached my tolerance level for them???? It happened while I was out of town one weekend visiting relatives. I awoke in the middle of the night to an upset stomache and ended up in the bathroom with diarrhea, sweating and chills. I was convinced I either had the flu or food poisoning. I eventually passed out on the cold bathroom floor tiles and when I woke up I felt fine. However for the next month I continued to have explosive watery diarrhea several times a day. When it came on it was instant and made me so sick but as soon as it was over I felt fine. I began to think I may be dying. I tried to think of every little thing I may have ate or drank that was not my normal. I eventually considered the melatonin gummies. To my amazement the diarrhea became less watery and less times a day! Weeks later I was totally back to normal. Thinking it may have just been a virus I started the melatonin again. The next day the diarrhea was back! I stopped again and it went away. I have been a little constipated this week so last night I thought.....why not? Let's try the melatonin! Stupid, I know, but guess what? The diarrhea came back today! Experiment over!!!! I am throwing these pills in the trash. It is definitely the source of my troubles. I hope this helps anyone out there that is still on the fence about them. Good luck to u all!

stillmary
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Date Joined Feb 2016
Total Posts : 1
   Posted 2/9/2016 1:57 PM (GMT -6)   
On lots of advice from friends, I took my first melatonin last night and the sleep benefits were outweighed by the sudden stomach cramps and awful diarrhea throughout the night. I immediately googled and see that this is a side effect no one really talks about in the open (understandably!). One dose is enough for me to discontinue use, after reading everything I've seen on the web. Thank you all for helping confirm what the problem was before I wasted any more time.

Bettsann
Regular Member


Date Joined Feb 2014
Total Posts : 278
   Posted 2/25/2016 3:03 PM (GMT -6)   
Well, here is the other side of it! :) I have taken 3 (sometimes 6 mg) of Melatonin at night a half an hour before I take my half of a Unisom...and I have never had this reaction...
I am so sorry if this is the cause of yours, Susie... because it really is a most excellent relaxer... Best wishes to you!

Skippy71
New Member


Date Joined Aug 2016
Total Posts : 1
   Posted 8/3/2016 6:39 PM (GMT -6)   
I believe melatonin can cause diarrhea. I have suffered from IBS since I was a child.

about 5 years ago I started having problems sleeping. about 4 years ago I started taking Lunesta, which works very well by the way. At one point, I thought I would give Melatonin a try to switch to something natural versus a manufactured drug. I took one chewable, and the next day I had very watery diarrhea and significant cramping. At the time, however, I was also sick with a virus, and so I thought it was from that. The diarrhea lasted 3 weeks.

Maybe a year later, I tried Melatonin again, one chewable, and again had watery diahrrea for several weeks, but again at that time I was ill and taking antibiotics.

So, last night, years later, as I was not sick, and my system was in good shape, I thought I would give it one more shot. Today, I was shooting liquid again, probably 10 visits to the restroom. I suspect that I will have loose stools for the next 3 weeks.

In each event, the first few days are the worst as far as having to find a restroom, and then the next several weeks is simply loose stools, some mild cramping, and intermediate urgency to get to the bathroom.

I will not take melatonin again.

IBS is a terrible affliction. Sometimes, often, it rules my life and prevents me from doing things. One of my biggest fears is having to ride on an airplane, and not being able to hold it until I can get to the lavatory, and soiling myself. And as you all probably know, it does not come out solid, but rather an awful liquid mess.

I suspect that this is extremely rare. Most people can probably take melatonin safely.

As melatonin is a hormone, I wish someone, research doctors, would take note of the connection between melatonin, the central nervous system, and IBS. There must be a connection.

For what it's worth...

Best wishes for all of you.

Lizabit38
New Member


Date Joined Jan 2017
Total Posts : 1
   Posted 1/24/2017 1:41 PM (GMT -6)   
I too have the all the same side effects. I have been eating differently so I decided what the heck give it a try again since the doctor would like for me to take this for my Tinnitus. so I tried yet another time and low and behold.. watery diarrhea and cramping.. so I will not try again.. I did really get good sleep when taking it.. but not worth it..

Dundee
New Member


Date Joined Jan 2017
Total Posts : 2
   Posted 1/29/2017 9:51 AM (GMT -6)   
Add me to the list of melatonin induced diarrhea, cramping and pressure. I took it for a month with no issues, then changed brands after running out...and on came the issue. I began the process of elimination re: diet changes, meds etc., and I hypothesized it may be the melatonin. Did a search...found this site and here I am to testify.
I'm done with the melatonin....it began as a friend and now has become my foe. skull

MLIND
New Member


Date Joined Feb 2017
Total Posts : 1
   Posted 2/11/2017 8:45 AM (GMT -6)   
I stopped the melatonin 2 days ago because of the horrible cramps and diarrhea. For those who had the same reactions, how soon before the diarrhea stopped. It is debilitating.

PeggyHill
New Member


Date Joined Feb 2017
Total Posts : 1
   Posted 2/15/2017 11:36 AM (GMT -6)   
Same here. I've been taking melatonin as a sleep aid for about a week and have cramps diarrhea EVERY MORNING.. I'm so sick of it. It wastes too much time when you're at work, plus it's embarrassing...Glad I googled it and found this page while stuck in the bathroom this morning. It's going in the trash!

Ljwest
New Member


Date Joined Feb 2017
Total Posts : 1
   Posted 2/18/2017 9:59 PM (GMT -6)   
I took it no problem for a year then all the sudden, cramps, gas, runs and then not to mention sharting!! I'm done, rather have insomnia than grap my pants! good for people who have constipation problems thou. BTW the runs last a day or 2

CooBax
New Member


Date Joined Feb 2006
Total Posts : 7
   Posted 3/3/2017 4:09 PM (GMT -6)   
OMG!

A year and a half ago I started Melatonin. Within a few months developed brutal diarrhea. Because I had recently stopped anti biotics my doctor thought it was c diff. He did not do any testing.

Around that time I went off of the Melatonin in case In had been the cause.

Now a year and a half later I started using melatonin again because sleep was getting worse.

Two weeks ago developed diarrhea again ( can not believe I didn't clue in ) so this time they did testing for c diff , Ova and parasite. C diff came back today as negative! Others test will be back tomorrow.

After reading this I am almost definitely convinced it's the Melatonin!!

Going to stop it completely and see what happens.

Thank you to everyone who posted here!

Lesley

Dallas
New Member


Date Joined Mar 2017
Total Posts : 1
   Posted 3/6/2017 9:00 AM (GMT -6)   
I am currently experiencing these exact same symptoms: Moderate cramping up to 3 times a day for an hour or so each time, and frequent, watery bowel movements; up to 5 per day. I've been to the doctor, and he suspected Dyspepsia (accumulation of excessive stomach acid), which apparently I'm the right age to start getting (I'm 36). He prescribed a probiotic capsule, which is making no difference.

These symptoms seem to line up with about a week after I started taking Melatonin consistently. I will stop taking immediately to see if the symptoms clear up.

This thread is very encouraging, as I am very, very frustrated with my body's rebellion as of late. I will update in a week or so with the results of stopping the Melatonin.

SusieQ5555
Regular Member


Date Joined Feb 2014
Total Posts : 26
   Posted 4/4/2017 11:36 AM (GMT -6)   
After stopping Melatonin my diarrhea disappeared within about 5 days. I have recently restarted it & I have reduced the dosage to just a quarter of 1 mg. sure enough the diarrhea started again but only once or twice first thing in the morning. It works so well for sleep that I am going to take it as needed. Obviously I am very sensitive but is it worth stopping it due to a little diarrhea first thing in the morning? With 1 mg I had chronic diarrhea. I cut the 1 mg tab into quarters. There is a liquid form available as well so I could try less than 0.25mg but I highly doubt it will make a difference. Any comments? I already take Clonazepam 2 mg before bed but it is losing effect....I know people can build up a tolerance to benzodiazepines & I certainly do not want to increase the disease. I may cut back on the Clonazepam to see if this makes a difference...there could be a drug interaction between Clonazepam & Melatonin but there is no info available that I have been able to find. At least the 0.25 mg is not debilitating.

SusieQ5555
Regular Member


Date Joined Feb 2014
Total Posts : 26
   Posted 4/4/2017 12:25 PM (GMT -6)   
How are you making out Dallas & others after stopping MELATONIN?

JTee1
New Member


Date Joined Apr 2017
Total Posts : 1
   Posted 4/26/2017 6:33 PM (GMT -6)   
I too had a horrific experience with Melatonin. It was given to me by a Naturalpath Doctor. I was to take 1 tablet that night, 1 mg then increase to 3 mg over the course of a week. I did not get past the first night. I woke up with horrible cramps, nauseous, gas pressure against my entire lower abdomen, including my bladder & uterus, fluctuated beween constipation & diarrhea. The brand was a high quality brand. I will never take Melatonin again. It took several days for the all of the symptoms to subside.

heylesley
New Member


Date Joined May 2017
Total Posts : 2
   Posted 5/12/2017 6:41 AM (GMT -6)   
BRAND OF MELATONIN = DIARRHEA? No one has mentioned what brand they're using. Anyone having an issue with Metagenics BENESOM?

I had been taking Physiologics Melatonin nightly for 5 years with great success (under the advice of my physician). In 2016, the Physiologics brand became unavailable. I switched to Metagenics - "Benesom" (again, at the advice of my physician) which contains Melatonin along with Chinese Skullcap, Valerian Root, and Passion Flower. A few weeks after the switch I experienced looser than usual stools which gradually worsened. Eventually I was running to the bathroom several times in the middle of the night with mad loose stools. After ruling out several strains of bacterial infection through lab work, my internist suggested a round of Flagyl (a known carcinogen!) followed by a colonoscopy if the anti-bacterial didn't work. I rejected both of these suggestions. On my own, I discontinued the two dozen supplements I take daily, including the BENESOM Melatonin. The diarrhea stopped in 24 hours. After a week of feeling great again, I added one-at-a-time daily to see what was giving me the diarrhea. Last night, I added the Benesom. This morning - BOOM! (Literally - LOL, sorry.) I think it's the BRAND of Melatonin creating my problem.


Please note: Metagenics is a high-quality, wonderful source of pharmaceutical grade supplements both my doctor and I trust. I believe this is just a case of my body's reaction to one of the herbal additives.

Post Edited (heylesley) : 5/16/2017 5:31:06 AM (GMT-6)


Relievedwithanseers
New Member


Date Joined May 2017
Total Posts : 1
   Posted 5/16/2017 3:14 AM (GMT -6)   
Wow! 5 months of watery diareah, stool samples, and a colonosophy I've found this thread. I started taking melatonin in December; by January I was in the bathroom 4-10 times a day. In December i was taking 3mg a day by Jan I had upped it to 6mg a day.

So happy to have found this forum. I did stop about 3 weeks ago as I was sleeping better and it subsided to one early morning watery stool. Then last week I took it again and I'm back to 4-6 times a day.

Definitely throwing out those pills.

heylesley
New Member


Date Joined May 2017
Total Posts : 2
   Posted 5/16/2017 5:24 AM (GMT -6)   
Relievedwithanseers - Glad you're feeling better! WHAT BRAND of melatonin were you taking, please?

Sleeper
New Member


Date Joined Jun 2017
Total Posts : 1
   Posted 6/3/2017 6:59 AM (GMT -6)   
I too experience cramping and severe diarrhea with 5 mg melatonin...my doc tested for c-diff and other parasites since I just had c-diff for first time in March after pneumonia....tests came back negative...doc said could very well be melatonin...our body only produces 0.5 mg at night and pumping in another 5 mg is going to create 10 times what body needs and dumps excess into bowels....hence the cramping and diarrhea...throwing out melatonin...going back to milk at bedtime...diarrhea just not worth it..btw.. I had tried several brands and results all the same

SusieQ5555
Regular Member


Date Joined Feb 2014
Total Posts : 26
   Posted 6/4/2017 9:48 AM (GMT -6)   
Well I'm back to report that I read the label on the Melatonin tablets & found it contained magnesium citrate which is a natural sleep aid but also a natural laxative! So I switched to Melatonin liquid...no magnesium. Each drop only contains 0.24 micrograms (mcg) & one drop is the equivalent of 1/2 of a 1 mg tab. I stopped the Melatonin tabs for 3 weeks then desperate for sleep I bought the liquid. First few days of 2 drops were great....then the diarrhea started & became worse. I can't believe such a small amount definitely causes diarrhea. It works SO well for sleep but I'm only going to take it if I'm desperate for sleep....Melatonin definitely causes diarrhea....🙁

MeJustMe
New Member


Date Joined Jun 2017
Total Posts : 1
   Posted 6/25/2017 8:48 PM (GMT -6)   
OMG, why is diarrhea NOT listed as a possible side effect. I've been battling with this explosive issue for a month. I've been eliminating EVERYTHING I could think of. Melatonin was my last supplement to stop, I stopped that last night, today, no more crapping. I normally have constipation, I'm like a crap twice a week gal, even went to ER once for upper back pain only to be told, the xray shows I'm full of crap literally. So imagine my concern going from that to suddenly nearly not making it to the bathroom in time, multiple times a day. I even resorted to adding iron, knowing that normally that would be a kiss of death for me, all it did was turn everything black (that's not disturbing :O) No impact at all on the watery diarrhea. Praise the lord, last night I stopped the melatonin! today I actually went to the bathroom and ONLY PEED!!! (that should NOT be the highlight of my day) So glad I found this forum, if anything it validates that I'm not the only one having this issue, I've been validated smile

Matt3055
New Member


Date Joined Jun 2017
Total Posts : 1
   Posted 7/1/2017 12:15 AM (GMT -6)   
Glad I found this forum. Started taking the gummy melatonin back in the beginning of April, everything was fine until the beginning of June when I too developed the cramping and sudden urge to go a couple times a day with loose stool. Went on vacation last Friday and decided to go to the walk-in clinic the Tuesday before as this was getting annoying. The doctor prescribed lomotil 2.5 mg 4/day. It really didn't do much even with the BRAT diet. The last couple days this week things started to get better and I continued the diet just to play it safe. Last night before bed I realized I had forgotten to take the melatonin the two previous night's so I took it and went to bed. Lo and behold the cramping and urgent need to go started again this morning. I thought it might have been caused by the change in diet the last couple days since I was feeling better, but as I was about to take melatonin tonight I decided to Google melatonin and diarrhea to find if there might be a correlation and the search brought me here! It's safe to say I have taken my last dose of melatonin.

robertpri
New Member


Date Joined Jul 2017
Total Posts : 1
   Posted 7/17/2017 1:53 PM (GMT -6)   
As a retired widower, I've had insomnia a long time and always welcome methods to sleep. Found melatonin some time ago and it worked perfectly. But after a few months, had fast and brutal diarrhea so I began eliminating foods one after another, thinking they were the cause.

Nope, it was the melatonin.

Luke4
New Member


Date Joined Aug 2017
Total Posts : 1
   Posted 8/4/2017 9:48 AM (GMT -6)   
Wow how is this not on the label I've been on melatonin for 4 months and for 3 months been pissing out of my arse. I wondered why the doctor looked at me weird and said they are normally for elderly people when i asked for these as they we're recommended to me. Thought I was dying..... do not drink alcohol with these tablets as the effect is x10 i some times even had 2 5mg.

Post Edited (Luke4) : 8/4/2017 10:23:38 AM (GMT-6)

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