I was on Zoloft and Welbutrin for a while, along with Levbid. When I got preg with my first child I went off all meds (and thankfully I had NO ibs with that pregnancy). It worked, except for the decreased libido from the Zoloft, which I will not take anymore for that reason, it was pretty bad. Recently I tried just Welbutrin and Levbid, but I ran out of Welbutrin and coming off of it was hell! I felt terribly depressed, it only lasted a couple of days, but I have kids to keep up with, and in those days I couldn't even get out of bed. Not sure if I want to be put back on it, but it did help while I was on it, I guess I would just have to stay on it. I hope I haven't scared anyone away from those meds, cause I'm sure they work in different ways for different people, it's always worth a try.