Your post interested me as I have been an IBSer for about three years now (alternating c&d) (and newly hypothyroid)and have also just been prescribed Zoloft to try and help with Anxiety/stress as nothing else (meds nor diet) have done anything to help with the IBS symptoms. One of my issues with the IBS is bloating and nausea which I HATE and really interferes with daily life and work. I have read on posts elsewhere that Zoloft can cause some mean nausea among mult. other side effects, so I am very nervous about actually starting the medication especially since it is an antidepressant. I was encouraged to see a couple positive experiences mentioned, however, I was wondering if you have started your medication yet and how it was going for you? Thank you!