I am on Amitiza. It has worked well but not without side effects. I suffer from nausea here and there. My gastroendrocrinoligist said it can cause nausea and usually goes away within 3 days after taking it for the first time. He told me it has to been with a meal everytime you take it and you should consume most if not all of you're meal before taking it. I find it helps a lot. If I get nauseated I eat something really small even a fruit popsickle in addition to my meal and it usually takes the nausea away.
What are you're symptoms? What do you mean by indigestion? Do you mean nausea, hunger, burping? Also, it helps to drive something afters. I drink an ice tea and that helps too.
I would be interested in exchanging info so we can help each other.