I found your post of 2007 regarding your experience with taking Prednisone and how it seemed to help your IBS.
I have had a similar experience, having IBS since the early 1970's, so I know where you are coming from. Years of colonoscopys, being put on Imuran for about five years, which seemed to help somewhat. I did notice a distinct improvement after being diagnosed with Hypothryoidism, and being put on Levothyroxine. My doctor said there was no connection, but since I had IBS for 35 plus years at that time, and boom, suddenly an improvement, I was convinced that there was indeed a connection. Then for the last five or six years being nearly housebound with increasing IBS symptoms left me nearly suicidal at times. Then, for an unrelated reason, was put on Prednisone for a five day, 10 tablet dose. I noticed an improvement of my IBS the following week, and now, three weeks later, the improvement is absolutely astounding, it leaves me amazed. It is like someone switched off what I have been experiencing for decades. I can still hardly believe it, seems like I have been born again, and I actually can say, "so this it what it feels like to be normal." For the first time in years I actually can go out to dinner with my family and not spend the evening in the "loo." So what you experienced with the Prednisone was NOT your imagination.
My annual physical with my doctor is coming up soon, and I have a good feeling that my doctor will blow off my hunch on this. Has anyone else out there had a similar experience? Side effects or not, I would ask to please put me on another five day dose if these symptoms return.
And no, I do not have Crohns, I have been diagnosed with IBS since 1970's.