Any advice/experience?

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beth0277
New Member


Date Joined Jan 2012
Total Posts : 17
   Posted 2/13/2013 1:22 PM (GMT -7)   
My husband is currently going through testing for proteinuria and I don't know what the issue is at this point. He has, for a few years, had either negative, trace, or +1 protein on a dipstick UA. He did a 24 hour test 3 years ago and it was normal, though I am not sure of the exact amount. He did one last month again, and this time it was slightly elevated at 218. They are testing him for all kinds of autoimmune disorders and so far the only test that has been positive is the serum protein electrophoresis which read: POLYCLONAL GAMMOPATHY: Serum protein electrophoresis demonstrates a diffuse polyclonal increase in the gamma region. No monodispersed zones are evident. Pattern is consistent with hypergammaglobulinemia (polyclonal gammopathy). Consider chronic infection, chronic liver disease, autoimmune diseases, sarcoidosis and other chronicinflammatory conditions.

So that test shows that *something* is going on, but so far testing for autoimmune disorders has been okay. ANA, Sedimentation rate, CRP, Anti-Double Stranded DNA, Rheumatoid Factor, and Cyclic Citrullinated Peptide have all been normal. They are also testing for Hepatitis although he gave blood a few years ago and I am pretty sure they screen for that when giving blood.

He had a kidney ultrasound that was also normal. Next step is meeting with nephrologist next week. I assume (?) they will order a biopsy.

Anyone have a similar presentation to this? My husband is 29, a little overweight but overall very healthy. Great blood pressure, cholesterol, all other blood work other than slightly high bilirubin and mild jaundice which he has experienced since he was an adolescent and was diagnosed with Gilbert's disease.

Anyone have any ideas?

Thanks in advance for any help! We are scared but trying to stay calm.
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