Low Dose Naltrexone?

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GregB777
New Member


Date Joined Dec 2007
Total Posts : 9
   Posted 12/27/2007 9:18 AM (GMT -7)   
Hi Everybody---
 
I'm new here.  I was wondering if anyone has tried Low Dose Naltrexone, and, if so, what results you had (good and bad.)
 
Any information would be greatly appreciated!
Sincerely,

GregB

AlwaysRosie
Veteran Member


Date Joined Jan 2005
Total Posts : 8616
   Posted 12/27/2007 11:19 AM (GMT -7)   
Hi Greg . . . sorry, I have note heard of this therapy. I see you have posted on 4 of the forums here . . . so I'm not sure if you have Lupus issues or another auto-immune disease.

Maybe one of the other members can help.

Blessings!

In His Grip

AlwaysRosie           "We can't control the waves, but we can learn how to surf!!"

Psalms 139

Co-Moderator - Lupus Forum

UCTD, Hashimotos, Inflammatory Bowel, Inflammatory Arthritis

Clickable Links:  Lupus Resources    Lupous.Org   Lupus Criteria (4 of 11)   Lupus Chapter Locator


canuckgirl
Regular Member


Date Joined Jan 2007
Total Posts : 146
   Posted 12/27/2007 12:01 PM (GMT -7)   
Hi Greg I have been taking this for a couple days what would like to know about it.
PM me if you have any questions
UCTD and sjogrens ( terrible dry mouth) Plaquenil 400 mg with 150mg of diclofenac as needed, all biotene products and refresh liquigel eye drops 


mom46
Veteran Member


Date Joined Dec 2004
Total Posts : 8198
   Posted 12/28/2007 10:15 AM (GMT -7)   

This is a new medicine to me too. Is it a anti-inflammatory? I'm always curious about new meds... :-) .                                                       Babs


 
Dx: Lupus,RLS,RA,Asthma,Fibro,Sjogren's,Raynaud's,Divertic, Stroke,Atherosclerosis,Seizures,Neuropathy,CAD
Meds:arava,prednisone,plavix,aspirin,protonix,,zanaflex,xanax,
mirapex,advair,foxamax,Vytorin,folicacid,lunesta,Tramadol
 
JOB 5:18 For he wounds, but he also binds up; he injures, but his hands also heal.


GregB777
New Member


Date Joined Dec 2007
Total Posts : 9
   Posted 12/28/2007 10:43 AM (GMT -7)   
Well, it is supposed to increase your body's endorphins. There was a recent published study that it helps with Crohn's disease, and a lot of anecdotal evidence that it helps with MS, Lupus and other autoimmune diseases.

Naltrexone is an opiod blocker and is used at full strength for those addicted to opiates. The theory is that for AI diseases, your body doesn't produce enough endorphins on its own. This leads to inflammation and AI disease. LDN (Low Dose Naltrexone) works like this: Your body normally produces most of its endorphins between 2-4 AM. If you take a very small dose of Naltrexone before going to bed, it blocks the opioid receptors in your brain. This is turn makes your body think you don't have enough endorphins, so it ramps up production on its own for a few hours. This extra endorphin that is now in your system stops AI reactions.

That's the theory, anyway.

Here's a site that list users experiences taking it:

http://www.revolutionhealth.com/drugs-treatments/rating/naltrexone-for-lupus

Not a heck of a lot yet on Lupus, but anecdontal evidence is encouraging. It seems to help a lot of autoimmune diseases, but the only peer reviewed paper so far is for Crohn's. There are a few trials underway right now.

http://www.lowdosenaltrexone.org/

http://www.lowdosenaltrexone.org/ldn_and_ai.htm

If you read that last article, you can see that at least in mice with lupus-like disease, low endorphins have been found.

It's all experimental right now. However, the drug is available for any doc to prescribe off-label right now, if you find one that is willing to give it a try. That site I gave describes the protocol. It is 3-4.5 mg once a day around 10 PM.

I haven't taken it myself. I'm still in the research phase.

canuckgirl
Regular Member


Date Joined Jan 2007
Total Posts : 146
   Posted 12/28/2007 7:05 PM (GMT -7)   
I am on day 7 of it I don't have a lupus dx but I do have a High ana titre of 1:2560 and positive anti rnp I have a UCTD dx with sjogrens symptoms but NO sun for me or rash.
UCTD and sjogrens ( terrible dry mouth) Plaquenil 400 mg with 150mg of diclofenac as needed, all biotene products and refresh liquigel eye drops 

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