Anti dsDNA keeps rising

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Gidget^
Regular Member


Date Joined Aug 2007
Total Posts : 171
   Posted 2/21/2008 2:05 AM (GMT -7)   
Over the last year my Anti dsDNA has continued to rise.  First blood test the showed 1500 (normal being 0 to 99).  Blood test last week was 2,697.  Rheumy has increased my Plaquenil.  My doctor is very concerned about the continued high results of this test and feels that I am on the verge of a big flare.  He's talked about putting me on Imuran or one of the chemo drugs.  I know there is not much use in worrying about it because it is out of my control, but I'm the type of person that likes to know one or two steps ahead what "might" happen.  I seem to deal with things better, though I think part of it is because I'm a control freek.   
 
I was wondering if there is anyone on the forum that has had to deal with such high numbers on the Anti dsDNA and what their dr. did for them?
 
Also, I was diagnosed by my ENT as having Meniere's.  My rheumy says it's another autoimmune disease.  I'd be interested in talking with anyone who has been diagnosed with this.


Gidget^
 
SLE 9/07, FMS '90's, Spinal Stenosis, Osteoarthritis, Sinus Tach, PVC's, Kidney Stones, RLS, Parotid Neurofibroma 8/04, Cervical Cancer 9/06, Enchondroma on my skull 11/07
Plaquenil, Toprol XL, Prozac, Zyrtec-D, Zocor, Vitamins B6 & B12, Pepcid, Folic Acid, Loratab ,Percoset, Toradol
 
There is no psychiatrist in the world like a puppy licking your face.
 
 


Ann Ireland
Veteran Member


Date Joined Apr 2006
Total Posts : 511
   Posted 2/21/2008 2:59 PM (GMT -7)   
Gee Gidget,
You ain't having an easy time.
I am a great one to talk but try not stress.
Today I didnt stress and my symptoms where much easier.
I hope you have the treatment that will taken down the high numbers, I dont really know much about this but it doe sound as if you are going through alot.
I am thinking of ye!
xAnn
Ann Ireland

Congenital Rubella Syndrome (CRS) Severely Deaf, Hypothyroidism, Pes Cavus, Crohns Disease, scoliolis, Hiatus hernia, diverticular disease, neuromuscular disorder (?parkinsons) movement disorder, ? another autoimmune disease.
Excema.

150mcg tyroxine, 20mg pantoprazole, 10mg Cipramil, 500mg 2 3times a day Mesalazine, 3mg Entocort, 62.5 Sinemet, 30mg Tamazipam, mystatin, sudocream


jhmom
Veteran Member


Date Joined Oct 2004
Total Posts : 2244
   Posted 2/21/2008 3:35 PM (GMT -7)   
Hi Gidget, (((hugs))) Imuran is a good med to treat lupus, I've had great results from it and wouldn't be able to function without it. I know it sounds scary especially when you read about it but remember Imuran is also used for people who have kidney transplants but their doses are a lot more than what we are prescribed to treat lupus, crohns, etc.

Info on test: A positive test means = In a person with lupus symptoms, a positive test almost always means that lupus is present. However, the test can also be positive in some patients with rare diseases.

Take care and keep us updated on how you are doing.
Stacie

Trust in the Lord with all thine heart, and lean not unto thine own understanding ~ Proverbs 3:5 ~

DX: Hashimoto's 1999, Celiac Disease (AKA: gluten sensitivity) 2003, Raynaud's 2004, Lupus 2005 and Sjogrens 2006
RX: Imuran, Plaquenil, Methotrexate, Flexeril, Piroxicam, Levoxyl, Folic Acid, Lortab (as needed), Magnesium Citrate and magic mouthwash (as needed for mouthsores)


Gidget^
Regular Member


Date Joined Aug 2007
Total Posts : 171
   Posted 2/21/2008 5:46 PM (GMT -7)   
jhmom ... you're probably thinking about ANA not the Anti dsDNA.  The ds-DNA antibody, which was first described in the 1950s, reacts with double stranded deoxyribonucleic acid (DNA). While antibodies to single stranded (ss) DNA are seen in many rheumatic and non-rheumatic conditions, antibodies to ds DNA are considered diagnostic for SLE. Rising and high titers of ds DNA antibodies suggest an increased risk of progressive disease.  
 
According to LabOne which is one of the labs that does the Anti dsDNA tests as well as the the rest of the subset of Lupus and other autoimmune tests say:

Table 1.—Autoantibodies in the Rheumatic Diseases2-5

Autoantibody Disease Associations  Condition                                                                 Frequency you'll see a positive with someone with Lupus. 
dsDNA (double-stranded DNA)          Systemic lupus erythematosus (SLE)           40% – 60%

With the exception of dsDNA, ANA titers and specific autoantibody levels have not been linked to disease severity; however, double-stranded DNA has been shown to correlate with clinically relevant disease activity,15 and results generated with this new technology are standardized to the World Health Organization’s dsDNA standard, wo/80.

Hycor whose products are used in Lupus testing as well as other types of testing says:  Anti-double-stranded (ds) DNA antibodies are found along with a wide variety of antibodies recognising other nuclear components in Systemic Lupus Erythematosus (SLE). SLE is a disease of unknown aetiology, being characterised by widespread organ involvement including renal, CNS and skin as well as joint disease. Anti-dsDNA antibodies have been suggested to be directly involved in the disease process, being included in the ARA criteria for the diagnosis of the disease. This involvement is thought to be due to either dsDNA-anti-dsDNA complexes which have been detected in some patients or to the cross-reaction of anti-dsDNA antibodies with other molecules such as the phospholipids or glycosaminoglycans of connective tissues and cell surfaces. In SLE patients, levels of anti-dsDNA antibodies can be used in the monitoring of disease activity, since rapid increases have been reported to precede exacerbation of the disease and falls in antibody levels often accompany drug therapy. Anti-dsDNA antibodies are not detected in the sera of patients with drug induced lupus.
 
LOL trust me ... I've done my homework. 
 
Hugs!
 

Gidget^
 
SLE 9/07, Meniere's Disease 2/08, FMS '90's, Spinal Stenosis, Osteoarthritis, Sinus Tach, PVC's, Kidney Stones, RLS, Parotid Neurofibroma 8/04, Cervical Cancer 9/06
Plaquenil, Toprol XL, Prozac, Zyrtec-D, Zocor, Vitamins B6 & B12, Pepcid, Folic Acid, Loratab ,Percoset, Toradol
 
There is no psychiatrist in the world like a puppy licking your face.
 
 


jhmom
Veteran Member


Date Joined Oct 2004
Total Posts : 2244
   Posted 2/21/2008 6:20 PM (GMT -7)   
Gidget, I'm glad you've done your homework, we've all done our fair share ;-) The part in my post came from what you see below, taken from Lupus UK site. I don't know much about the anti-dna, that's why I love this place, we can all learn from each other and what we all have been though. Take care

www.uklupus.co.uk/antidna.html

Anti-DNA

Normal Range = < 1:10 titer.

Anti-DNA is an immunoglobulin specific against native (double-stranded) DNA

It is increased in Systemic lupus erythematosus & is highly specific to SLE.
Sixty to eighty percent of patients with active SLE have a positive anti-DNA test.

Anti-ds-DNA antibody is not found in drug-induced lupus.
Titers of anti-ds-DNA correlate well with disease activity and with occurrence of glomerulonephritis.

<<<<A positive test means = In a person with lupus symptoms, a positive test almost always means that lupus is present. However, the test can also be positive in some patients with rare diseases.>>>>>

A negative test means = a negative test does not mean that lupus is not present.
Stacie

Trust in the Lord with all thine heart, and lean not unto thine own understanding ~ Proverbs 3:5 ~

DX: Hashimoto's 1999, Celiac Disease (AKA: gluten sensitivity) 2003, Raynaud's 2004, Lupus 2005 and Sjogrens 2006
RX: Imuran, Plaquenil, Methotrexate, Flexeril, Piroxicam, Levoxyl, Folic Acid, Lortab (as needed), Magnesium Citrate and magic mouthwash (as needed for mouthsores)


Gidget^
Regular Member


Date Joined Aug 2007
Total Posts : 171
   Posted 2/23/2008 10:55 AM (GMT -7)   
hmmmm now that is the first time I've seen that. Doubtful that it is from anything else, my lupus is active and doctors aren't considering anything else besides Lupus. Thanks for the info, I'll have to ask rheumy what other diseases increase the Anti dsDNA.
Gidget^
 
SLE 9/07, Meniere's Disease 2/08, FMS '90's, Spinal Stenosis, Osteoarthritis, Sinus Tach, PVC's, Kidney Stones, RLS, Parotid Neurofibroma 8/04, Cervical Cancer 9/06
Plaquenil, Toprol XL, Prozac, Zyrtec-D, Zocor, Vitamins B6 & B12, Pepcid, Folic Acid, Loratab ,Percoset, Toradol
 
There is no psychiatrist in the world like a puppy licking your face.
 
 


jhmom
Veteran Member


Date Joined Oct 2004
Total Posts : 2244
   Posted 2/23/2008 11:56 AM (GMT -7)   
I'm sure it's just showing your lupus activity. I would be interested in knowing what other diseases increase the anti-dna too. I hope you are feeling well. Take care
Stacie

Trust in the Lord with all thine heart, and lean not unto thine own understanding ~ Proverbs 3:5 ~

DX: Hashimoto's 1999, Celiac Disease (AKA: gluten sensitivity) 2003, Raynaud's 2004, Lupus 2005 and Sjogrens 2006
RX: Imuran, Plaquenil, Methotrexate, Flexeril, Piroxicam, Levoxyl, Folic Acid, Lortab (as needed), Magnesium Citrate and magic mouthwash (as needed for mouthsores)

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