Help with ANA titer

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doodlebee
Regular Member


Date Joined Mar 2008
Total Posts : 60
   Posted 3/2/2008 1:14 PM (GMT -6)   
I don't understand the titer and what it means. My doctor told me mine is positive but didn't say whether it was high or low, and at the time, I didn't know to ask.

It was 1:1280 homogenous.

Can anyone tell me if that is a high or low positive and what it means, and also what the homogenous pattern means?

My friend who is a nurse said she has seen more false positive ANA tests than anything, so I wonder if it could be false positive?

Lynnwood
Forum Moderator


Date Joined May 2005
Total Posts : 5604
   Posted 3/2/2008 1:31 PM (GMT -6)   
Hi,

If you look at the Lupus Resources thread (second from top) there is a post that describes they patterns and what they mean. There is a lot of information about lupus in the links at the bottom of this post.

Glad you joined us here -- ask away! :-)

Lynnwood, Co-Moderator: Lupus Forum

Dx Lupus since '00, new Dr wants to Dx Fibro instead....
SLE(’00), Sjogren's Syndrome, Raynaud's Syndrome, SAD, Depression, Herpes Simplex 1
Piroxicam, Plaquenil, Prednisone, Xanax, Trazodone, Boniva(3mth shot), Wellbrutrin SR, Valtrex
Links: DIAGNOSING LUPUS (4 of 11), LUPUS INFORMATION, LUPUS RESOURCES, Donate to HealingWell, Drug Interactions



jhmom
Veteran Member


Date Joined Oct 2004
Total Posts : 2244
   Posted 3/2/2008 1:32 PM (GMT -6)   
***ANA Titers and Patterns
ANA laboratory reports include a titer (pronounced TY-tur) and a pattern.

The titer indicates how many times the lab technician had to dilute plasma from the blood to get a sample free of the antinuclear antibodies. For example, a titer of 1:640 shows a greater concentration of anti-nuclear antibodies than a titer of 1:320 or 1:160. The apparent great difference between various titers can be misleading. Since each dilution involves doubling the amount of test fluid, it is not surprising that titer numbers increase rather rapidly. In actuality, the difference between a 1:160 titer and a 1:320 titer is only a single dilution. This does not necessarily represent a major difference in disease activity.

ANA titers go up and down during the course of the disease, and a high or low titer does not necessarily mean the disease is more or less active. Therefore, it is not always possible to determine the activity of the disease from the ANA titer. A titer above 1:80 is usually considered positive. Some laboratories may interpret different titer levels as positive, so one cannot compare titers from different laboratories.

The pattern of the ANA test can sometimes be helpful in determining which autoimmune disease is present and which treatment program is appropriate.
The homogeneous, or smooth pattern is found in a variety of connective tissue diseases, as well as in people taking particular drugs, such as certain antiarrhythmics, anticonvulsants or antihypertensives. This homogenous pattern is also the one most commonly seen in healthy individuals who have positive ANA tests.

The speckled pattern is found in SLE and other connective tissue diseases

The peripheral, or rim pattern is found almost exclusively in SLE.

The nucleolar pattern, with a few large spots, is found primarily in people who have scleroderma****
______________________________________________________________________________________

Your ANA is considered very high. The important question is what kind of symptoms do you have? I hope the information above helps answer your questions.
Stacie

Trust in the Lord with all thine heart, and lean not unto thine own understanding ~ Proverbs 3:5 ~

DX: Hashimoto's 1999, Celiac Disease (AKA: gluten sensitivity) 2003, Raynaud's 2004, Lupus 2005 and Sjogrens 2006
RX: Imuran, Plaquenil, Methotrexate, Flexeril, Piroxicam, Levoxyl, Folic Acid, Lortab (as needed), Magnesium Citrate and magic mouthwash (as needed for mouthsores)


doodlebee
Regular Member


Date Joined Mar 2008
Total Posts : 60
   Posted 3/3/2008 5:55 PM (GMT -6)   
Your ANA is considered very high. The important question is what kind of symptoms do you have? I hope the information above helps answer your questions.
______________________________________________________________________________________

Thank (both of) you for all the information and links. I spent a good deal of time yesterday reading it, and I can see there are no easy answers. I think I just really want to know if a titer of 1:1280 could possibly be a false positive, but it apparently just isn't that simple. The rheumatologist said, "It's definitely positive." So maybe she means it's too high to be a false positive? But everything else was negative/normal, except for my vitamin D, so I keep hoping the high positive ANA won't mean anything.

As far as my symptoms, right now, they are mainly fatigue and painful (but not swollen) joints, dry eyes and mouth, and occasional bouts of nausea. Today, it feels like my whole body is nauseous. Then I have a history of weird symptoms and labs...unexplained fever every night for months, low platelets, low potassium that sent me to the ER, severe reactive hypoglycemia, etc. I don't have rashes except on my face, which the doc said looks like rosecea. I don't have mouth sores or sun sensitivity. Well, I do burn easier than I used to, but don't get rashes from it. Not too long ago, I had insanely frequent urination, especially at night, but that has gotten better. And one time, years ago, there was a day when I could not urinate for the whole day and night...dunno why that sticks in my mind. It was just weird and felt really bad.

Anyway...what it boils down to is, I'm scared. I'm just digging for answers, but guess I just need to try not to consume myself with it and put on my sunglasses for now and try to be patient with the waiting game. scool

Post Edited (doodlebee) : 3/3/2008 3:58:21 PM (GMT-7)


jhmom
Veteran Member


Date Joined Oct 2004
Total Posts : 2244
   Posted 3/3/2008 10:01 PM (GMT -6)   
I don't think a high ANA such as yours could be a false positive, I think that is only if the numbers are much lower, but I am not a doctor. My ANA was 1:640 and it was high enough to get the doctors attention. At that time I think that was the only positive test I had besides the SED which measures inflammation (there are several tests that check this and not all of them are positive).

It sounds like something is definitely going on with the symptoms you are having. Your doctor should run some other lab tests, get your family history and symptoms. Here are some links for you to check out.

www.uklupus.co.uk/dxlupus.html Criteria list to help dx it

www.uklupus.co.uk/tests.html List of blood test used in the dx process

I really hope you get some answers soon. When do you go back to the doctor?
Stacie

Trust in the Lord with all thine heart, and lean not unto thine own understanding ~ Proverbs 3:5 ~

DX: Hashimoto's 1999, Celiac Disease (AKA: gluten sensitivity) 2003, Raynaud's 2004, Lupus 2005 and Sjogrens 2006
RX: Imuran, Plaquenil, Methotrexate, Flexeril, Piroxicam, Levoxyl, Folic Acid, Lortab (as needed), Magnesium Citrate and magic mouthwash (as needed for mouthsores)


doodlebee
Regular Member


Date Joined Mar 2008
Total Posts : 60
   Posted 3/4/2008 12:05 AM (GMT -6)   
Thanks, I go back in mid April. At that time, I guess she will see how my symptoms are after being on vitamin D for 8 weeks and will probably do labs again then.

lnr4
New Member


Date Joined Apr 2008
Total Posts : 2
   Posted 4/3/2008 4:04 PM (GMT -6)   

Hi,

Like yourself, I also had an ANA Titer that was >1:1280 Homogenous.  I also had a positive ESR (sedimentation) of 26. My doctor told me not to be alarmed but I have an appointment with a Rheumatologist. I heard these could both be signs of pregnancy.  Has anyone else heard that?

I am in good health but have started experiencing vertigo, headaches, fatigue, the tips of my fingers will go numb and turn gray/blue, my eyes are sensitive to light, and achyness in my legs.  Also, I have been struggling with very high cholesterol.  None of these symptoms, however, interrupt my daily activities or are unbearable.  I am very scared.  I am 23, run, play sports, and am very active.  I have a great diet b.c I am very conscious of my high cholesterol.  My mother has MS and Epiplepsy so my doctor had me get an MRI and I am seeing a Neurologist to rule out MS. 

Does anyone have any insight?  Are my symptoms and test results reason for alarm?  ANy information would be much appreciated.  I cannot stop thinking about all the awful possibilities.

Thanks, Lisa 

 


Sabintha
New Member


Date Joined Sep 2008
Total Posts : 2
   Posted 9/18/2008 12:39 PM (GMT -6)   
Lisa,   In reference to your post in April:
 I'm not a doctor but your symptoms sounds like Raynauds or thyroid disease, possibly both. I have hypothyroidism and have similar symptoms. I hope this helps.
 
 
 
 
 
                                               Sabintha

lnr4
New Member


Date Joined Apr 2008
Total Posts : 2
   Posted 9/18/2008 1:07 PM (GMT -6)   
Thanks Sabintha!  Since the last post, I was diagnosed with Raynaud's and I was negative for MS and a few other conditions.  I haven't had my ANA Titer checked since, but I am very curious if it is still high.  What are some of the symptoms that you had with Hypothyroidism?  How was it diagnosed?
 
HOpe all is well.   

Sabintha
New Member


Date Joined Sep 2008
Total Posts : 2
   Posted 9/19/2008 12:41 PM (GMT -6)   
Lisa,
 
       I currently have a ANA titer of <1:320 Speckled pattern.  Also, my immunogobulin igm is low (25) other than that, all my other blood work falls in the normal range. I go back to the neurologist Sept.22nd to find out what all this means. Some of the symptoms I was experiencing was fatigue, hair loss, dry skin, extreme thirst, achy joints,cold extremeties, memory fog. I also have been diagnosed with fibromyalgia. (It can mimmick MS) There is no test to determine if you have fibromyalgia other than a doctor asking you questions and eliminating all other possibilites. With fibromyalgia, you have achyness in several places. You can have 11-18 "trigger points"- where the pain is mainly coming from-and it's very hard to treat. Also, after I was diagnosed with fibromyalgia, I became more sensitive to light, to the heat and cold. This new blod work I had done recently was because I have had sudden worsening symptoms..stabbing pain in left side of buttocks and left shin and burning-tingling in the right side. I was in so much pain, I had trouble sleeping  and when I finally did sleep, I would awake to severe pain. My legs (around the knee area) and my feet swell and if they hang down for long periods of time, they change colors,hurt, and sometimes tingle. I had an injury to my back which just seemed to be getting worse. They don't think it's my back though because all my tests are coming back good. You might want the doctor to test you not only for fibromyalgia and thyroid disease, but also lupus. To test the thyroid they need to do a sensitive test. It doesn't always show up otherwise. The tests to have done for the thyroid are the tsh, the t3 and t4. I hope this helps. I wish the best for you. If I can be of further assistances, or if you need someone to talk to, just email me.
 
 
                                                                     Sabintha
 
 
 

whats_wrong_with_me?!
New Member


Date Joined Sep 2010
Total Posts : 1
   Posted 9/6/2010 10:53 PM (GMT -6)   
hi i was just wondering how doodlebee is going, i came accross this as i got the exact same blood results as you the other week, i have seen a rhuematologist and have been told he doubts i have lupus, but was not very helpful with detemining what the cause of the blood tests were. i also had a back xray that showed degenerative disc disease. i was wondering if doodlebee was diagnosed with anything as maybe i could have the same thing.
 
thanks     smilewinkgrin

LAWCHICK
Regular Member


Date Joined Jul 2010
Total Posts : 105
   Posted 9/7/2010 1:58 PM (GMT -6)   

My ana was 1:160 and it was enough to gain attention from my DR ( that was 4 years ago). Your ANA is very high. I recently met with my DR and he actually told me that many docs do not take ANA into consideration when diagnosing Lupus because ANA is so unreliable. He said that it can change (go from pos to neg) he said he treats patients usually based on past ANA test and also current symptoms that they have.

 

Your test however is high and your symptoms are similar to mines. I tested positive for lymes so my DR did not officially diagnose me  with Lupus, he wanted to treat me for lymes first and see what happened. Well I just finished a 21 day lyme treatment and I feel the same. Now I have to go back to see whats next.

 

I am in no way as expierenced as some are on this forum as all of this is still new for me too but I figure I can offer tibits here and there.


Kemistry
New Member


Date Joined Feb 2011
Total Posts : 1
   Posted 2/21/2011 12:20 PM (GMT -6)   
All threads posted are very interesting. about 7yrs ago, I was diagnoised by a Neurologist with a sever case of sinusitis/allergies only becuase I was itching, my head was clogged with limited breathing and proven blood work showed that my ANA TITER were reading 1:78/Speckled. The DR prescribed (at the time) prescription Zyertec that should be taken every 12hrs EVERY day. Me hating medicine and the affect associated with them, I only take one tablet MAYBE every third day. Or until I can't take the itching! After about one year into this, I was contacted by the DR stating that I needed to come in for couseling to discuss my ANA TITER count from a year before. More test showed negative for rhemthoid arthritis, negative for Lupus and negative for MS. After several sticking of needles and val's of blood still no diagnosis, I finally couldn't take it any long -- I STOPPED going!!!! I'm regreting it now, b/c the itching has actually gotten worse, I now am starting to get dizzy with fog which about a year ago only would hit me every other month, now have increased to hit me about 1per month. The more I research the scarey its becoming. I don't have symptoms such as pain in joints nor any other pain -- however I do experience weight fluxuation and not even having the urge to uninate, even after 3 bottle sof 16 oz waters -- love it' (hate sodas). I call myself being a healthy eater. My diet is simple, not to much fried but a lot of veggies -- love em'. Not sure if this fits this forum, but any and all responses are welcome. May be able to share with my NEW Dr.....we really gotta figure something out!!! Thanks.

LovesSummer
New Member


Date Joined Apr 2011
Total Posts : 1
   Posted 4/19/2011 3:20 PM (GMT -6)   
My ANA is 1:80 with a speckled pattern.  My blood counts are ...
WBC is 3.0 , Platelets are 143 and my red counts bounce around.
My legs ache throughout,... including my joints, but I don't notice any inflamation or redness.  I get headaches everyday.   IB Profin doesn't really help.    I feel like I'm "off" because I lose my focus.  Inside my head I feel a bit overwhelmed or like too much is going on when I close my eyes.   My energy level is low and sometimes I get nautious or dizzy.  
 
I'm now in my mid 40's but was diagnosed with early menapause at 38.   I have slight hair loss since my last child was born.  I have a sensitivity to cold, ....I bruise easily.   I occasionally have hemorrhoids.
 
I went in to my primary care physician to discuss the possibility of a thyroid condition..... but all is normal there...   My TSH is 1.285
 
I've seen a hemotologist and he's says that I don't appear to have lupus...  He's referring me to a rheumatologist....but...
 
What else could this be??

Lynnwood
Forum Moderator


Date Joined May 2005
Total Posts : 5604
   Posted 4/19/2011 3:41 PM (GMT -6)   
There are a number of auto-immune diseases that have positive ANA readings. Until you get to a rheumatologist, it's pretty much a guess - the final diagnosis has to do with symptoms - there are no definitive tests that absolutely say "yes" or "no" to lupus. The rheumies are the ones with the education and the experience to diagnosis and treat auto-immune diseases - the other drs really aren't qualified.

Hope you get to feeling better soon,
Lynnwood, Lupus & Sjogren's Moderator
DIAGNOSING-LUPUS & LUPUS-RESOURCES
"Life is far too important to be taken seriously" - Oscar Wilde

Littlesrebel
Regular Member


Date Joined Jul 2009
Total Posts : 163
   Posted 4/20/2011 2:25 PM (GMT -6)   
Sounds like you need some medication for those symtoms. Get that straigten out quick.
Fibromyalgia, SLE Lupus,chronic myofacia pain syndrome, cerivcalgia, malaise, fatigue, migraines, and anxiety.

Bill-1
New Member


Date Joined Jul 2011
Total Posts : 1
   Posted 7/12/2011 7:59 AM (GMT -6)   

Write down every Symptom you have experienced over past two yesrs. Pay Attention to the following symptoms:

Dizziness

Short or long term memory loss

Weakness (Symetrical or on only one side)

Pain (Symetrical or on only one side)

Inflamation (Symetrical or on only one side)

Swelling (Symetrical or on only one side)

Rashes and where

Neuropathy (numbness and tingling) in feet or hands

Skin color changes due to temperature or stress

Dryness in eyes, mouth, and or throat

Mouth sores

Vitamin D Deficiency (Are you on Prescription Vitamin D)

Major Hair Loss
 
Tremors in fingers or hands (and how often, are you exercising at time or at rest)
 
Have you been involved in Physical Trama (like car accident or fall)
 
What medications are you on
 
What Vitamins and supplements are you on.
 
Note There are several diseases that are highly associated with various cancers, get complete check up by a Rheumatologist, he will usually direct you to see a Dermatologist for skin care, Opthamologist (not Optometrist) for checking you out from Autoimmune association with their specialty. For example Sjogren's affects eyes and mouth and throat with dryness and sores. Skin problems could be beginning stage of Lupus or Dermatomyositis along with the other symptoms you mentioned. Also ANA can be there one day and negative the next in some people with a disease. Not sure what happens once you go on the medications for treatment. You may need to see a pulmonologist to look for signs of lung cancer, and a Gastrointernologist to look for throat, stomach, and colon cancer via two different procedures. You will also be referred to a Cardiologist if you have specific Autoimmune diseases to check for heart disease, high CHL, etc...
 
It usually takes a good team of doctors before you are diagnosed properly. Sometimes it takes a while because you may not have all the signs for a while, and sometimes they are confused because you probably have or will develop other autoimmune diseases such as overlap syndrome. It is frustrationg to the doctor and much mor so to the patient. You need courage, trust, and family and friends support.
 
My first and last ANA Test was done in 2002 after having skin signs and muscle fatique. It was Positive, Homo, with a Titre of 1:80. It was dismissed by my primary doctor as either probably something related to misdiagnosed RA in 1990, or a false positive. The test was never repeated. Today I have advanced stages of Dermatomyositis-Polymyositis, Secondary Sjogren's, and Secondary Raynaud's Phenonema, and some symptoms of SLE such as hand and fingers treamors and symetrical rash on my cheeks, eyelids, neck, chest, thighs, elbows, and Gottron papules on my finger knuckles,  along with symetrical muscle pain and weakness in my neck, arms, legs, hip, and back. and firey inflamation and pain in my hands and feet.
 
I have not been in remission since 2007, the Rheumatologists did not run another ANA test since I was confirmed to have DM by Biopsy and the treatment is fairly the same for these autoimmune diseases that are so closely linked. He will be running it this week, I think, unless the MTX and IVIG Treatment I am on has an impact on the test and its results being inaccurate.

stella6923
New Member


Date Joined Aug 2011
Total Posts : 1
   Posted 8/21/2011 7:58 PM (GMT -6)   
Hello,I am new on this forum.I have High ANA everything else is fine when it came to bloodwork.Even though i still battle with many of these conditions you all have.I recently found out  that it was all happening because of Celiac and some food allergies.Have any of you been tested for this? Or even tried to  go gluten free for awhile to see if symptoms subside?
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