I think it's a bit different for everyone, but I really start to notice it if I'm on 15mg or higher. I also have to be on that dose for about 2 months before the moon face kicks in. I haven't had that since 2002. As soon as I got below 10mg, it started to go away.
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p.s. Hey, I was BORN with a moon face, so I don't know what you guys are talking about....actually the prednisone really helps my generalized edema be less. I have been on a maintenance dose for a year, after trying high dose, 40/30/20/10 mg monthly tapers for flares that happened every three months. And I have yearly bone density scans, (I'm still in the green zone, thank God) and just started taking calcium citrate with D, and two Omega 3 fish oil caps, (after reading about a Mayo clinic study about it's benefits with lupus as an anti inflammatory that was in my Lupus newsletter).
Chubby faced hugs to all,