Methotrexate & joint pain....

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jhmom
Veteran Member


Date Joined Oct 2004
Total Posts : 2244
   Posted 3/11/2008 3:50 PM (GMT -7)   
I have taken 4 doses and I am still in such pain sad eyes skull mad

When will this end? I thought for sure I would feel an improvement by now.... but... nothing. The only thing that has improved is my WBC, RBC & Hematocrit. My AST and ALT improved a little but still higher than they have been. Back in Dec they were 18 & 16, then in Feb they were 35 & 56 and now they are 34 & 42. I go back this Friday for another check on my labs. I see my rheumy in a couple of weeks, maybe there is another alternative for me.

Anyway, sorry for the whine... just feeling down and in pain! confused Hugs to all
Stacie

Trust in the Lord with all thine heart, and lean not unto thine own understanding ~ Proverbs 3:5 ~

DX: Hashimoto's 1999, Celiac Disease (AKA: gluten sensitivity) 2003, Raynaud's 2004, Lupus 2005 and Sjogrens 2006
RX: Imuran, Plaquenil, Methotrexate, Flexeril, Piroxicam, Levoxyl, Folic Acid, Lortab (as needed), Magnesium Citrate and magic mouthwash (as needed for mouthsores)


Barbara Lee
Veteran Member


Date Joined Sep 2003
Total Posts : 2889
   Posted 3/11/2008 6:05 PM (GMT -7)   
Hi Stacie:

(((((hugs))))) I'm so sorry to hear that you're not feeling any better. I know we get our hopes up that a certain drug is our miracle drug and we'll immediately start feeling good again. I just wanted to let you know you're in my thoughts and prayers and I hope you begin to start to feel better soon.

Love,
Barb
dx fibro, SLE, glaucoma, cateracts, bells palsy, depression, migraine headaches, gastreopaersis, chronic anemia, RA,MDS (Blood Cancer). Tons of meds.


Trying2BFree
Regular Member


Date Joined Oct 2005
Total Posts : 251
   Posted 3/12/2008 7:17 AM (GMT -7)   
I took about 2 months for me to really tell a difference with MTX.  Try to be patient with it, I know it's frustrating. {{Hugs}}  My liver tests have jumped up before like that but they usually come down.  I'm taking 15mgs.  How much are taking?
Jeannie 
SLE diagnosis 10/05 now changed to RA 3/06, Endometriosis 5/05, PCOS 1990
Meds: Metformin ER 1500mg (PCOS); Loestrin BCPs (Endo); Methotrexate 15mg (RA); Metanx 5mg (RA); Orencia 750mgs (RA); Lunesta 2mg (as needed); Prevacid


jhmom
Veteran Member


Date Joined Oct 2004
Total Posts : 2244
   Posted 3/12/2008 7:37 AM (GMT -7)   
Thanks ((( Barb & Jeannie ))) , I am on 7.5 (3 tabs a week). If I tolerate the low doses well maybe my rheumy will up it a little when I go back in a couple of weeks. I was really hoping it would work quicker than this, I know everyone is different, I will be patient and give it time to do what it needs to do. yeah

Thank you both so much for your hugs & encouragement, I am so glad we are not alone while dealing with this disease. Hugs to all
Stacie

Trust in the Lord with all thine heart, and lean not unto thine own understanding ~ Proverbs 3:5 ~

DX: Hashimoto's 1999, Celiac Disease (AKA: gluten sensitivity) 2003, Raynaud's 2004, Lupus 2005 and Sjogrens 2006
RX: Imuran, Plaquenil, Methotrexate, Flexeril, Piroxicam, Levoxyl, Folic Acid, Lortab (as needed), Magnesium Citrate and magic mouthwash (as needed for mouthsores)


Butterflake
Forum Moderator


Date Joined Jun 2006
Total Posts : 1548
   Posted 3/12/2008 9:10 AM (GMT -7)   
(((Stacie))) I know you feel like dog poo right now (I'm sick too), but try to be patient with the mtrx.  Ultimately the mtrx lowered my blood pressure and glucose (blood sugar) which in itself makes taking mtrx worth it to me.  Hugs!  Love, Butterflake
Dx: SLE ('05), depression, diabetes, fibromyalgia, gerd, sleep apnea (use a CPAP), hypertension, IBS
Tx: CellCept plaquenil methotrexate prednisone prozac celebrex lisinopril actos lipitor nexeum seroquel arthritis tylenol multi vitamin C calcium/D flaxseed oil  PRN: ambien neurontin promethazine xanax
             Better living through chemistry :D    Donna
 


AlwaysRosie
Veteran Member


Date Joined Jan 2005
Total Posts : 8616
   Posted 3/12/2008 8:59 PM (GMT -7)   
Hi Stacie,

Oh my . . . I was looking at your med list. *sigh* Your MTX dose is really low. I like that the doc is being cautious . . . but wow . . . I thought starting dose of 15 mg (twice your dose). I started at 15 and had to go up to 20 mg. . . . but I wasn't taking Imuran.

Looking back on those really hard two years . . . I wish he'd tried to zap my flare with prednisone. I wouldn't want to stay on it . . . but OY!! Enough is enough.

You should call his office and explain how aweful you still feel. It might be good if you had the couple week BEFORE your next appointment to see what happens on the higher dose.

Was the Imuran to take the place of pred??? I can't remember . . . sorry.

((((((((((((( Stacie ))))))))))))) Some hot tea for you sis!

Blessings!

In His Grip

AlwaysRosie           "We can't control the waves, but we can learn how to surf!!"

Psalms 139

Co-Moderator - Lupus Forum

UCTD, Hashimotos, Inflammatory Bowel, Inflammatory Arthritis

Clickable Links:  Lupus Resources    Lupous.Org   Lupus Criteria (4 of 11)   Lupus Chapter Locator


jhmom
Veteran Member


Date Joined Oct 2004
Total Posts : 2244
   Posted 3/13/2008 4:00 PM (GMT -7)   
Thank you Donna and Rosie,

Donna, I am trying to be patient with MTX, I know it has worked so well for others, I'm just waiting on it to kick in for me. It has brought up my WBC, etc which is good. I hope you feel better too!

Rosie, thank you for the tea, I really needed it. Yeah I guess she started me off on a low dose because I take 100mg of Imuran and I have to keep taking it for other problems that lupus causes. I've never been on Pred either, maybe I could use a dose pack or maybe I will do like you suggested and call the office to let her know I don't see much of an improvement yet, thinking about it, my feet don't seem to hurt as bad during the day but my fingers, hands, back and hips still hurt.

Thanks again ladies, you all are great!
Stacie

Trust in the Lord with all thine heart, and lean not unto thine own understanding ~ Proverbs 3:5 ~

DX: Hashimoto's 1999, Celiac Disease (AKA: gluten sensitivity) 2003, Raynaud's 2004, Lupus 2005 and Sjogrens 2006
RX: Imuran, Plaquenil, Methotrexate, Flexeril, Piroxicam, Levoxyl, Folic Acid, Lortab (as needed), Magnesium Citrate and magic mouthwash (as needed for mouthsores)


smokeyswife
Regular Member


Date Joined Oct 2006
Total Posts : 281
   Posted 3/14/2008 5:45 AM (GMT -7)   
Aww Stacie I am sorry to hear that you are hurting so bad. I have been on Mehotrexate for a long time now, well it seems like a long time, a couple of years now anyway and recently my Rheumie tried to lower my dosage. He told me that it would take 6 to 8 weeks before i noticed a difference in how I would feel. Boy was he wrong. Within 3 weeks I was in agony again, swollen fingers and joints and I just hurt so bad. It took me a week of calling his office to get ahold of him, he told me to go back to the dosage that I was on and he would try again in about 6 months. So I feel for you. I want to get off of it but there is no way my body is ready for that yet.
 
I hope you can get some relief shortly, everyone else here has given you great advice. Good luck, I hope you feel better soon.
 
Connie
 
 
 
 
diagnosed with RSD in March of /03, diagnosed with Lupus in Sept./06.
Taking Methotrexate, Plaquenell, Folic Acid, Synthroid,Prednisone, Pantoloc, Singulair, Tramadol, OxyCodeine and extra Strength tylenol when needed,and Zytram.


elcamino
Veteran Member


Date Joined Sep 2005
Total Posts : 1744
   Posted 3/14/2008 6:37 AM (GMT -7)   

Sorry to hear it hasn't worked well for you just yet.  With me, it took 2-3 months for mtx to kick in--I guess that translates to about 8-12 doses.  Also, I had to increase it to 15 mg (from 7.5mg)/ week to see the maximum benefit.

Hope you feel better soon,

El


Current dx: Rheumatoid Arthritis
Suspected dx: UCTD/Early Lupus
Current Meds: Enbrel, Plaquenil, Methotrexate, nexium, tramadol, nasonex,Tylenol PM
Past Meds: Relafen, Vioxx, Mobic, Voltaren, Sulfasalazine, Entocort, Prednisone, Humira, Reglan, zyrtec, zegerid, aciphex


Dakota0917
Regular Member


Date Joined Oct 2007
Total Posts : 100
   Posted 3/14/2008 7:27 PM (GMT -7)   

Hey Stacie...

Sorry you are in so much pain... 
My rheumy put me on 15 mg/week starting last October.  Said in would take 10-12 weeks to kick in.

I've been trying to wean off prednisone and got down to 7 mg/day.  However, my labs are still too high, so I'm not allowed to reduce prednisone anymore and the rheumy has upped my methotrexate to 20 mg/week.

It was explained to me that prednisone is the quick-acting drug to get the inflammation knocked down.  The meth also reduces inflammation - but takes longer to get into your system. 

~Kim

 

 


SLE: 07/07, Irritable Bowel Syndrome, migraines
400 mg. plaquenil, 9 mg. prednisone, 2400 mg. ibuprofin, 15 mg. methotrexate, folic acid, asacol, caltrate-D, wellbutrin, paxil, lybrel, Keppra (as needed)


jhmom
Veteran Member


Date Joined Oct 2004
Total Posts : 2244
   Posted 3/15/2008 8:58 AM (GMT -7)   
Thanks Connie, El and Kim - I go back to the rheumy April 3 so maybe if she doesn't see an improvement she will increase it. If it starts working it will be worth the wait.

My joints don't "visibly swell", they just hurt does that make a difference? Thanks again! Hugs to all
Stacie

Trust in the Lord with all thine heart, and lean not unto thine own understanding ~ Proverbs 3:5 ~

DX: Hashimoto's 1999, Celiac Disease (AKA: gluten sensitivity) 2003, Raynaud's 2004, Lupus 2005 and Sjogrens 2006
RX: Imuran, Plaquenil, Methotrexate, Flexeril, Piroxicam, Levoxyl, Folic Acid, Lortab (as needed), Magnesium Citrate and magic mouthwash (as needed for mouthsores)


smokeyswife
Regular Member


Date Joined Oct 2006
Total Posts : 281
   Posted 3/15/2008 3:53 PM (GMT -7)   
Hey Stacie. That makes sense to me. My joints swell but the only way I can tell is that my rings get really tight and I can't move them, but you can't tell looking at my fingers that they are swollen.
It took a long time for the methotrexate to work on me, but it was evident very quickly on how much it was helping me once he lowered the dosage.
Good luck, hopefully it will start to work for you very soon and you can get some much needed relief.

Connie
 
 
 
 
diagnosed with RSD in March of /03, diagnosed with Lupus in Sept./06.
Taking Methotrexate, Plaquenell, Folic Acid, Synthroid,Prednisone, Pantoloc, Singulair, Tramadol, OxyCodeine and extra Strength tylenol when needed,and Zytram.


littleCookie
New Member


Date Joined Mar 2008
Total Posts : 8
   Posted 3/15/2008 5:36 PM (GMT -7)   
Hey Stacie, I have just started taking the methotreaxate for two weeks now, I'm still waiting for the result, and it makes me sleepy. My Doctor told me that it would take a little time before you would see any difference in the way you feel....Well I'm still waiting for that real good feeling. My you be bless, the Lord knows all about him and trust that he will see you through it.

Littlecookie

jhmom
Veteran Member


Date Joined Oct 2004
Total Posts : 2244
   Posted 3/15/2008 6:04 PM (GMT -7)   
Thank you Connie, I am so glad it works well for you, it gives me some hope.

Thank you Littlecookie, it looks like we're both waiting for MTX to work wonders for us! I pray it works well for you and soon!!! Take care
Stacie

Trust in the Lord with all thine heart, and lean not unto thine own understanding ~ Proverbs 3:5 ~

DX: Hashimoto's 1999, Celiac Disease (AKA: gluten sensitivity) 2003, Raynaud's 2004, Lupus 2005 and Sjogrens 2006
RX: Imuran, Plaquenil, Methotrexate, Flexeril, Piroxicam, Levoxyl, Folic Acid, Lortab (as needed), Magnesium Citrate and magic mouthwash (as needed for mouthsores)


Dakota0917
Regular Member


Date Joined Oct 2007
Total Posts : 100
   Posted 3/16/2008 6:06 AM (GMT -7)   

My joints have never swollen...they just hurt.

~Kim


SLE: 07/07, Irritable Bowel Syndrome, migraines
400 mg. plaquenil, 7 mg. prednisone, 2400 mg. ibuprofin, 20 mg. methotrexate, folic acid, asacol, caltrate-D, wellbutrin, paxil, lybrel, Keppra (as needed)

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