I know I have asked this question before but I am asking it again anyway

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Regular Member

Date Joined Mar 2007
Total Posts : 194
   Posted 4/11/2008 4:26 PM (GMT -6)   
Ok sooooooooo, I the Dr at JH's . I had a lab result come back with a high Complement 4 . It has been high 3 times in a row. I have looked and researched the internet for 2 days now. Lupies have LOW complement levels! I decided to grab the bull by the horns and email the Dr. and ask her about it. Her response was that this can happen in Lupus patients . I was hoping for an answer as to why. I cant find anywhere to support a high C4 in Lupus. I saw a high C4 in cancer but I dont have cancer. 

Veteran Member

Date Joined Dec 2006
Total Posts : 2818
   Posted 4/11/2008 4:45 PM (GMT -6)   
Complement levels can be increased with inflammation, rising before other markers such as the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP).

I actually just took this off the internet. It really didn't say much else or I would have given you the link. I read this in a couple of places. It sounds like if your Lupus is active it can cause cause the high complement levels.
I hope it helps a little anyway.

God Bless
Lupus like symptoms, stage 4 COPD w/CHF,  Cancer survivor.  Osteoporosis,osteoarthritis
Prednisone,Plaquanil800mg,vicodin 4x5mg,Evista60mg, Effexor 150mg, HCTZ25/Triamterene37.5mg,Xanax 1.0 x3,Singular,nitro spray, aciphex, percocet 10mg.x4.,lasix,inderal,pot.chlor.,B12 
I will never leave you nor forsake you!

Veteran Member

Date Joined Sep 2005
Total Posts : 2573
   Posted 4/11/2008 5:10 PM (GMT -6)   
Complement levels are often high before a flare and low at the end of one. You have to remember complement levels are only one way of gaging immune activity. Simply put some tests can be way off just because they are. Blood work is not the end all be all and no one test should be allowed to affect you this much unless it is one for cancer that is positive (as in lukemia). Believe me blood work can be wacky and still mean absolutely nothing in terms of clinical significance- then again labs can be normal and all kinds of crud can be happening.
Dx:fibromyalgia 2002, systematic lupus 2005- definate CNS involvement dxed late 2005, psoriasis 2006, rheumatoid arthritis 2006, PTSD 2007, multiple allergies 2005, migraine, compression fractures T11 & T12, Sj√∂gren's, damaged periphrial nerves 2007, pregnant due May 2008
Tx: plaquenil, Enbrel, Darvocet, Singulair, Flexeril, Baby Asprin, Imuran, Procardia, Prilosec

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