Provigil anyone? New drug from the rheumie, also new Voltaren gel

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cured4real?
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Date Joined Dec 2005
Total Posts : 1944
   Posted 5/29/2008 7:57 PM (GMT -7)   
I'm trying Provigil from my rheumie. It is a new sort of stimulant type drug that is not an amphetamine and it is supposed to help with concentration and brain fog and fatigue from sleep apnea.  My rheumie says he has several patients on it and they really like it. Anything will be great if it makes my brain work.  Since my markers are down, he wants to try this to see if I can get through with it and avoid steroids for a while. As long as I have my mind, that is good. It is also supposed to have a mild euphoric effect and doesn't seem to have any great bad side effects outside mild nausea, which I already have.  I'm sleeping like 12 to 18 hours lately and am very sluggish. If it can help me be active again so I can exercise and have more of a life, it would really help.  I will let you know what it does. I tend to have very bad reactions because of my liver, so I'm probably not the greatest indicator. He is only giving me a half dose though so I should be ok.
 
He also gave me a muscle relaxing gel for my joints. I can't take voltaren because I can't metabolize it well, but since the gel is absorbed through my skin, it will bypass my liver and stomach. I do well with meds through the skin. It's something to try if you have liver or stomach problems.
 
Love, Marji
--Sometimes I think the surest sign that intelligent life exists elsewhere in the universe is that none of it has tried to contact us. Bill Watterson (1958-) cartoonist "Calvin and Hobbes"
Ills--Sjogrens-Lupus-like AI Disease, Hashis, Vitiligo, spinal stenosis/fusion with plate, salivary/lymphectomies, Diabetes, NAFLD, COPD, RLS, neuropathy, trigonitis, hystero, diffuse brain atrophy, GI nightmare
Meds--Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, Estradiol patch, Prosed, Detrol, Klonopin, Ultram, Vicodin, Restasis, Albuterol, steroid injections and pred prn


okie
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Date Joined Dec 2006
Total Posts : 2818
   Posted 5/29/2008 8:06 PM (GMT -7)   

Hey hun, my best friend out here in okie ville is on provigil. She's been on it a long time. She suffers from Leukemia (is in remission) :-) . She also has Fibro. She takes it every morning. She said there is no way she could get out of bed and function without it. She was a little concerned about her liver but she said she was afraid it might hurt her liver over time. She hasn't found anything any where as close to working as well as the provigil. I'm not sure what your insurance is but I notice a website advertised on here that will send you a coupon for a 7 day trial of provigil. No she doesn't seem to suffer any bad side effects. She does have sleep apnea and uses a Cpap at night.

I hope it works great for you!

love ya

carol 


God Bless
Depends on which rheumy you ask! stage 4 COPD w/CHF,  Cancer survivor.  Osteoporosis,osteoarthritis
Prednisone,Brovana, Pulmacort,zythromyacin,vicodin 4x5mg,Evista60mg, Effexor 150mg,Xanax 1.0 x3,Singular,nitro spray, aciphex,lasix,inderal,pot.chlor.,B12 
I will never leave you nor forsake you!
 
 
 


cured4real?
Veteran Member


Date Joined Dec 2005
Total Posts : 1944
   Posted 5/29/2008 9:25 PM (GMT -7)   
Thanks, Carol! That's really good to know. Really, the worst fear I have is the fear it will give you that awful feeling of coming down when it wears off, like anxiety. But it doesn't seem to work like amphetamines and it doesn't say that it will do that. there is a very very very small percentage, like one pct that get that and I think the same amount get it with a placebo. I'm so glad to hear it is working good. I just have to start moving. I'm getting so stiff. I guess they are investigating it for adhd so it may be an option for my son's adhd too. I hope medicare will cover it, but if it won't I will have to find the money if it works. The lack of energy is so bad, I think my overall pain would be better if I just had the energy to move.

Put the voltaren gell on tonight and already my neck is feeling better for localized pain--the pain the neurosurgeon said no medicine or surgery would fix. Also helped pain in big toe and knees where I applied it. Very very cool stuff. No side effects, not knocked out from it. Just pain free.

Took the lumbar pain away too. Even though I've got it for joints, they said I can use it for the back too, just not too much, I have to alternate where I apply it, but it's great, much better than muscle relaxing pill.

Take care and thank you so much for the info about the provigil. I will take it tomorrow morning. I hope so much that it works well. Once again, Carol, you are a Godsend. Thanks and hope you are doing well. I'm getting so bad I'm starting to look like Java the hut! I need to get going.
Love, Marji
--Sometimes I think the surest sign that intelligent life exists elsewhere in the universe is that none of it has tried to contact us. Bill Watterson (1958-) cartoonist "Calvin and Hobbes"
Ills--Sjogrens-Lupus-like AI Disease, Hashis, Vitiligo, spinal stenosis/fusion with plate, salivary/lymphectomies, Diabetes, NAFLD, COPD, RLS, neuropathy, trigonitis, hystero, diffuse brain atrophy, GI nightmare
Meds--Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, Estradiol patch, Prosed, Detrol, Klonopin, Ultram, Vicodin, Restasis, Albuterol, steroid injections and pred prn


cured4real?
Veteran Member


Date Joined Dec 2005
Total Posts : 1944
   Posted 5/30/2008 9:11 PM (GMT -7)   
Wow, provigil is great! So far so good. The side effects are rare, I felt a tiny bit of nausea and a little bit of nervousness when I first took the pill, but i had to break it in half so sometimes they don't dissolve right and get a little strong at first. Also, it was my first time taking it. I actually was able to go outside and putter around in the shed and pick some blueberries. And I swam more and did more around the house.

It gives you the mental ability/energy of the prednisone without the side effects. And everytime during the day when I thought it would start wearing off and I would feel anxious or nervous, instead I felt a wave of euphoria and the medicine kicked right back in. It was like prozac for anxiety in a way. And I felt really wonderful all through the day and settled gently down into a very lucid and relaxed state. No jagged up and down. It lasted from 10am till now and I'm yawning and tired and ready to sleep.

Apparently the drug excites discrete neuronal areas of the brain that normal stimulants don't. I think it will be excellent for ADHD because it doesn't give you anorexia, and doesn't make you feel bad when it wears off.

It is a dopamine reuptake inhibitor and an adrenal stimulant. It also is a broncho and vasodilator. It helped my asthma a lot by opening up my bronchial tubes and I coughed up stuff in the morning from the tubes opening up.

So far, it seems like a real possibility. I am taking a half a 200mg, but maybe could take a half a 100mg, and it might have helped, I don't know. but the 100mg seems good. I don't know if you become used to it.

It also seemed to diminish my pain somewhat, I think just because it made me more active and sped up my metabolism. I also think I will end up losing weight on it even though I do eat on it, I will exercise more.

My rheumie says that everyone he has put on it really like it. It does seem to really help with the mental part and fatigue, which never seems to go away for me, even when my inflammatory markers are normal.

So, it is definitely worth a try. I think as an ADHD med, it will become a real hit. They are doing clinical trials now. It would be nice for kids with ADHD to be able to sleep at night and eat on their medicine and also to not feel lousy when the medicine wears off.

So far so good. Had a really good day, and it does deliver as advertised, not only wakefulness but euphoria.
Love, Marji
--Sometimes I think the surest sign that intelligent life exists elsewhere in the universe is that none of it has tried to contact us. Bill Watterson (1958-) cartoonist "Calvin and Hobbes"
Ills--Sjogrens-Lupus-like AI Disease, Hashis, Vitiligo, spinal stenosis/fusion with plate, salivary/lymphectomies, Diabetes, NAFLD, COPD, RLS, neuropathy, trigonitis, hystero, diffuse brain atrophy, GI nightmare
Meds--Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, Estradiol patch, Prosed, Detrol, Klonopin, Ultram, Vicodin, Restasis, Albuterol, steroid injections and pred prn


okie
Veteran Member


Date Joined Dec 2006
Total Posts : 2818
   Posted 5/30/2008 9:37 PM (GMT -7)   
Hey that's awesome news! did your insurance pick it up? Like I told ya in the post before my friend is on it and she can't live without it. She is a little on the thin side but she has a good appetite. She's been on it for quite some time and only takes as directed and she can tell if she forgot to take it. So I really don't think it' somthing that will stop working. Also you own adrenilin could be effect it too. Just being able to get out and do somthing helps my whole attitude. Good for you I am so happy for ya!
love ya
carol
God Bless
Depends on which rheumy you ask! stage 4 COPD w/CHF,  Cancer survivor.  Osteoporosis,osteoarthritis
Prednisone,Brovana, Pulmacort,zythromyacin,vicodin 4x5mg,Evista60mg, Effexor 150mg,Xanax 1.0 x3,Singular,nitro spray, aciphex,lasix,inderal,pot.chlor.,B12 
I will never leave you nor forsake you!
 
 
 


cured4real?
Veteran Member


Date Joined Dec 2005
Total Posts : 1944
   Posted 5/30/2008 9:57 PM (GMT -7)   
Your post really made me not afraid to try it and I'm glad I did. If I can make it through two months without an allergic reaction, it should be smooth sailing! It's a great alternative to steroids when you want your mind back at least and some energy!
Love, Marji
--Sometimes I think the surest sign that intelligent life exists elsewhere in the universe is that none of it has tried to contact us. Bill Watterson (1958-) cartoonist "Calvin and Hobbes"
Ills--Sjogrens-Lupus-like AI Disease, Hashis, Vitiligo, spinal stenosis/fusion with plate, salivary/lymphectomies, Diabetes, NAFLD, COPD, RLS, neuropathy, trigonitis, hystero, diffuse brain atrophy, GI nightmare
Meds--Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, Estradiol patch, Prosed, Detrol, Klonopin, Ultram, Vicodin, Restasis, Albuterol, steroid injections and pred prn


okie
Veteran Member


Date Joined Dec 2006
Total Posts : 2818
   Posted 6/4/2008 7:35 PM (GMT -7)   
Hey Marji, I was wondering how you were doing with the provigil? You said somthing about trying to cut the dose in half. Did you do that? Is it still working for ya or any side effects? I'm kind of courious about it myself.
hugs
carol
God Bless
Possible sclero.  stage 4 COPD w/CHF,   Osteoporosis,osteoarthritis
Prednisone,Brovana, Pulmacort,zythromyacin,vicodin 4x5mg,Evista60mg, Effexor 150mg,Xanax 1.0 x3,Singular,nitro spray, aciphex,lasix,inderal,pot.chlor.,B12 
I will never leave you nor forsake you!
 
 
 


cured4real?
Veteran Member


Date Joined Dec 2005
Total Posts : 1944
   Posted 6/4/2008 7:56 PM (GMT -7)   
Well, I took a couple days off because I still felt good even now! It had a long lasting effect. So I gave the old liver a rest and have asked the rheumie for a lower dose and hopefully he will phone it in for me. I think that will be great. I don't know about taking it every day unless I take a much lower dose. I really threw my back out being so active and it reduced my pain, so that isn't good either. I'm thinking about trying it again on the weekend and hopefully before then I will have the lower dose, and I will try that. Taking 50mg might be the cat's meow.

I love the Voltaren gel. It works FANTASTIC on my neck, where I had so much surgery, and my lower back, as well as shoulder and knees. I have to alternate locations, but it's worth it. For my neck alone, it is great. Lower back too. It doesn't give you pill side effects and works great. Even if you don't have liver problems I would recommend it because there's no point in taking yet another pill when you can use a gel and not hurt your liver and kidneys. Pills have to be eight times stronger than the dose indicated to last all day, and the medicine effects you in an up and down fashion. The gel, like patches, is even and the right dose from the start. It's good stuff.

The provigil is far superior to Adderall, Ritalin, Straterra, and the other ADhD meds and really helps like pred does. I want to have it as an option for sure, though I like the fact I don't necessarily have to take it every day. My doc gives me a daily dose, but understands that in my unique case, it can get too strong. It could make you get kind of goofy if it was too strong.

I'll let you know when I get the hundreds and can take a fifty dose. It did work for days in regulating my sleep and readjusting my dopamine so that I was less fatigued and more active and content.

I would try it, though I would try a low dose first if you are prone to panic attacks or sensitive to meds or have heart problems. You could always raise it.

I had some heart irregularity when it wore off, beating irregularly and rapidly, but it went away with food, milk, and time and nightime meds (klonopin). My bp remained low.

There is no known antidote for it. Benzodiazapines don't seem to slow it down, antacids make it stronger, milk seemed to mildly help, food helps alot to slow down the breakdown. I would check with your doc about that, if it gets too strong, what you can do. I plan to talk with mine about it. So far, I use the milk thing and exercise to try to clear it a little and it works well. I'm really sensitive to meds though, really bad.

It's a keeper though. I hope you are doing better. It might be something to try definitely. Let me know.
Love, Marji
--Sometimes I think the surest sign that intelligent life exists elsewhere in the universe is that none of it has tried to contact us. Bill Watterson (1958-) cartoonist "Calvin and Hobbes"
Ills--Sjogrens-Lupus-like AI Disease, Hashis, Vitiligo, spinal stenosis/fusion with plate, salivary/lymphectomies, Diabetes, NAFLD, COPD, RLS, neuropathy, trigonitis, hystero, diffuse brain atrophy, GI nightmare
Meds--Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, Estradiol patch, Prosed, Detrol, Klonopin, Ultram, Vicodin, Restasis, Albuterol, steroid injections and pred prn

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