I vote call your dr.'s office first. Slow taper down/off is the rule, but if disease activity is increasing significantly as evidenced by increased symptoms, you might need a BIG increase in dosage. Like right away. My dr. is great, I wish I could share him. He says I am the best judge of how I feel and how much prednisone I need. I just call the "triage' nurse and they are great about phoning in a script.