Leigh, I have had problems with plaquenil. I get pretty severe edema in my legs and hands from it. The doctors solution to this is to give me more pills to counteract this side effect. Finally they agreed to reduce the dosage and gave me permission to not take it a couple days a week so I can dump the extra water. I also have developed an odd rash. I get it when my feet or legs get cool or cold after being warm, ie. after I take off my shoes and socks or after I get out of the shower. PCP, rheumy, neuro, and dermatologist all say it is not the Plaquenil but I am convinced it is the med since it started after beginning the med. What "strange things" have you been experiencing?
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CD, Ankylosing Spondylitis, lupus, small fiber peripheral neuropathy, avascular necrosis, peripheral artery disease, degenerative disc disease, and a host of other medical problems.