Anti-dsdna- test results question

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Leigh1978
Regular Member


Date Joined Sep 2008
Total Posts : 35
   Posted 10/22/2008 10:55 AM (GMT -7)   
When I forst had bloodwork done (when symptoms first started), I tested highly positive for the anti-dsdna.....1 month later (and 2 weeks after taking plaquenil), my anti-dsdna is now normal.

Is this something that happens often?
I am really confused.

redrose77
Veteran Member


Date Joined Sep 2005
Total Posts : 2573
   Posted 10/22/2008 11:56 AM (GMT -7)   
the blood work varies greatly by day and lab. one day your ana could be high positive and the next negative or positive at one lab and negative at another. at least that is what my rheumy says.
Dx:fibromyalgia 2002, systematic lupus 2005- definate CNS involvement dxed late 2005, psoriasis 2006, rheumatoid arthritis 2006, PTSD 2007, multiple allergies 2005, migraine, compression fractures T11 & T12, Sjögren's, damaged periphrial nerves 2007, exema
Tx: plaquenil, Enbrel, Tramadol, Singulair, Skelaxin, Baby Asprin, Imuran, Prilosec, lasix, Evoxac, Celebrex, Darvocet when things get too bad, prednisone again, various vitamin/mineral supplements, now cellcept


Leigh1978
Regular Member


Date Joined Sep 2008
Total Posts : 35
   Posted 10/22/2008 12:35 PM (GMT -7)   
If the labs vary and now my ANT-dsdna is normal, after being highly positive (but my ANA, SSA, SSB are still positive), was i misdiagnosed?

redrose77
Veteran Member


Date Joined Sep 2005
Total Posts : 2573
   Posted 10/22/2008 1:54 PM (GMT -7)   
no, labwork is not the sole basis of diagnosis. If it was then you neede a different doctor. BTW the other labs are still positive which indicates that the original labwork was likely correct.

I have all negative tests but am diagnosed because I more than meet the criteria
Dx:fibromyalgia 2002, systematic lupus 2005- definate CNS involvement dxed late 2005, psoriasis 2006, rheumatoid arthritis 2006, PTSD 2007, multiple allergies 2005, migraine, compression fractures T11 & T12, Sjögren's, damaged periphrial nerves 2007, exema
Tx: plaquenil, Enbrel, Tramadol, Singulair, Skelaxin, Baby Asprin, Imuran, Prilosec, lasix, Evoxac, Celebrex, Darvocet when things get too bad, prednisone again, various vitamin/mineral supplements, now cellcept


Leigh1978
Regular Member


Date Joined Sep 2008
Total Posts : 35
   Posted 10/22/2008 3:50 PM (GMT -7)   
Thank you both for your responses. Between the doc appointment, blood work and med. side effects, I think I'm starting to lose my mind!
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