genetics - family members with Lupus

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Tá mé breá
Regular Member

Date Joined Aug 2008
Total Posts : 140
   Posted 12/10/2008 3:52 PM (GMT -6)   
I know that AI diseases are genetic but not technically hereditary. But here is some family history for you - My maternal grandmother has Lupus, my mother has lupus and RA, My niece just found out she has Lupus because she had a bad case of blood clots. My daughter has pleurisy and a positive ANA so they are looking into lupus. I have not been officially diagnosed yet but I go to the Rheumy on the 26th. I think we should go in for a study or something!!!
Marie-43 yr old mother of 6 grandmother of 1 going on 2!
dx 2008 - myelofibrosis - possibly autoimmune, osteoarthritis in spine, testing for possible MS or CNS lupus / vasculitis. family history - mother RA/Lupus maternal gma - lupus.
rx-cymbalta, propranolol, clonazapam, prednisone, progesterone cream, b6, b12, flaxseed oil, C.

"All we have to decide, is what to do with the time we are given" ~ Gandalf

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Date Joined Sep 2005
Total Posts : 2573
   Posted 12/10/2008 4:21 PM (GMT -6)   

My great grandma had lupus, her sister had MCTD, my grandmother has lupus, one of her sisters died from lupus induced kidney issues, 2 of her other sisters have serious health issues that are lupus like, my mother has fibromyalgia, her sister also has fibromyalgia,  I have lupus, fibromyalgia, and RA (actually more see my signature), my little sister is showing signs of a problem, my oldest daughter has raynauds (she is 14).

There was a study for which I submitted a genetic sample, my family didn't choose to participate but I am sure there are other studies.

Dx:fibromyalgia 2002, systematic lupus 2005- definate CNS involvement dxed late 2005, psoriasis 2006, rheumatoid arthritis 2006, PTSD 2007, multiple allergies 2005, migraine, compression fractures T11 & T12, Sj√∂gren's, damaged periphrial nerves 2007, exema
Tx: plaquenil, Enbrel, Tramadol, Singulair, Skelaxin, Baby Asprin, Imuran, Prilosec, lasix, Evoxac, Celebrex, Darvocet when things get too bad, prednisone again, various vitamin/mineral supplements, now cellcept

Veteran Member

Date Joined Feb 2003
Total Posts : 5514
   Posted 12/10/2008 5:26 PM (GMT -6)   
WOW, that is a very high genetic link in your family. 
I'm the exact opposite.  I'm the only one on both sides of my family with AI diseases. We have even consulted my 90 year old grandmothers (who are both still alive and probably in better shape than me and have excellent memories), and both have said that no one as far back as they could remember, had an AI disease either.  I'm unique.  Aren't I lucky? 
I can do anything through Jesus Christ who strengthens me. I have learned in whatever state I am in,to be content. Phillipians 4:11-13

34 years old. Diagnosed with Lupus in 2000. Fibromyalgia, Anti-phospholipid syndrome(APS)(stroke, 2002), Sjogren's, Raynaud's, Libman Sach's Endocarditis, vasculitis, sacroiliitis, arthritis (neck), anxiety. Prednisone, Imuran, Coumadin, Clobazam, Amitriptyline, Didrocal, Cozaar, Zoloft, Neurontin, calcium, multi-vitamin, vitamin D, Magnesium, vitamin B6, Acidophilus

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Date Joined Jul 2005
Total Posts : 5403
   Posted 12/10/2008 6:41 PM (GMT -6)   
My aunt had lupus and died from both complications of lupus and diabetes. There is a lot of RA on my mom's side of the family and my son has a positive ANA with lots of joint pain, but docs can't agree on what he has (very frustrating).
Diagnosis:  UCTD (lupus) 2006; Raynauds 2006; Sjogren's 2006; lupus symptoms began 2003; UC 2008; CFS 1991; Mono 1985
Meds:  Plaquenil 400mg; Prednisone 5-10mg; Tramadol 100mg 3-4x daily; Doxepin 25-50mg; Prevacid; Evoxac; Steriod Cream and Mouth Rinse for tongue and mouth ulcers; Hydrocodone 5/500 prn for severe pain; Artificial tears



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Regular Member

Date Joined Aug 2006
Total Posts : 142
   Posted 12/10/2008 6:55 PM (GMT -6)   
My paternal grandma had RA. On my maternal side I had an aunt with MS and they thought Lupus too. I have an uncle with Psoriasis (also AI if u didnt know). I have 2 cousins with Aspergers (thought to be AI) and about 9 aunts/uncles on both sides with thyroid issues which are often autoimmune too. My dad has excema.
Besides my aunt with MS I didnt even know they all had these problems until I started having symptoms.
Dx: UCTD vs autoimmune spondyloarthropathy vs psoriatic arthritis (ie Limbo x5 yrs) Raynaud's, proteinuria
Rx: Plaquenil 400mg, Ultram PRN, Sulfasalazine 2 gram

Melissa D.
Regular Member

Date Joined Aug 2008
Total Posts : 330
   Posted 12/10/2008 8:07 PM (GMT -6)   
I definitely believe there is genetic link in AI, obviously the stories listed above prove it more so then ever. My father has Chrohns and has been disabled from RA for as long as I can remember. I have 3 sisters who have major thyroid issues, to the point were it puts them in the hospital, one of them has had thyroid cancer. I have an aunt on my Dad's side that has lupus.

When I began having major issues the doctors thought I had Chrohns, as I stated before I have always had stomach issues. Then I was diagnosed with Lupus, Fibro, and most recently Raynauds and Sjorens. Both my son and daughter show signs, I actually had my son tested for Lupus when he was around 10 or 11 because his symptoms were so severe, everything came back negative, but still to this day he has issues. My daughter has PCOS (polycystic ovarian syndrome) she has a lot of issues that mimic Lupus as well, rashes, joint and muscle pain, welts on her skin, severe headaches, fatigue and things tend to get worse around her time of the month. I wouldn't be suprised at all if one or both of them are diagnosed in the future.

Every interesting topic. Thanks for sharing.

Lupus - 1997   Fibro - 2001    Sjorens  -  2007   Raynauds  -  2008
Plaquenil, Imuran, Prednisone, Synthroid, Topomax, Effexor, Norco, Prilsec, Xanex, Elidel, Restasis

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