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Regular Member

Date Joined May 2008
Total Posts : 57
   Posted 1/16/2009 11:31 PM (GMT -6)   
Hello everyone. Hope you all are doing well. I just wanted to ask if anyone has experienced stomach pain with their lupus? Lately I have had an upset stomach and abdominal pain and I know Im not sick. I have no fever and it just hurts! I havent been able to eat in the last few days and my lupus is flaring as well. Let me know if you experienced this.
Medications: Prednisone 5mg. Plaquenil 300mg. Methotrexate 12.5mg. Naproxen (for pain). Multivitamin. Calcium. Fish Oil. Vitamin D. Flaxseed oil. Folic Acid.
15 years old. Lupus, and Raynauds.

Audrey Ann
Veteran Member

Date Joined Jul 2005
Total Posts : 815
   Posted 1/16/2009 11:51 PM (GMT -6)   
Greetings! I have frequent nausea and stomach pain. My rhuemy tells me to take prilosec because the meds we take cause this. I see you take methotrexate and this was the worst for me as far as nausea is concerned, anyway. The prednisone can cause the nausea or upset stomach, too. Prilosec really helps me and, try drinking milk and eating a little something before taking these meds. Also, do you drink a lot of beverages with caffiene? My rhuemy says this can aggravate the stomach, too. The caffiene, along with the meds, can cause us lots of stomach problems. Check with your rhuemy on this, but mine tells me to keep taking the prilosec even after the fourteen day dose is over. With a doctor's permission, you can exceed the fourteen day dose. Good luck - my prayers are with you!
Audrey Ann
Lupus, RA, and (Maybe) Fibromyalgia and LOTS of Medications!


Veteran Member

Date Joined Feb 2003
Total Posts : 5514
   Posted 1/18/2009 5:52 PM (GMT -6)   
How much and how often are you taking the Naproxen? NSAIDs are really hard on the stomach.  I had to come off my Naproxen a few months ago. I feel better all over now.  These drugs do a lot of yucky stuff.  Bloating, increased blood pressure, internal bleeding, etc.  Take with caution, and let your doctor know okay.
I can do anything through Jesus Christ who strengthens me. I have learned in whatever state I am in,to be content. Phillipians 4:11-13

34 years old. Diagnosed with Lupus in 2000. Fibromyalgia, Anti-phospholipid syndrome(APS)(stroke, 2002), Sjogren's, Raynaud's, Libman Sach's Endocarditis, vasculitis, sacroiliitis, arthritis (neck), anxiety. Prednisone, Imuran, Coumadin, Clobazam, Amitriptyline, Didrocal, Cozaar, Zoloft, Neurontin, calcium, multi-vitamin, vitamin D, Magnesium, vitamin B6, Acidophilus
Moderator for the Lupus and Fibromyalgia forums

Melissa D.
Regular Member

Date Joined Aug 2008
Total Posts : 334
   Posted 1/19/2009 11:32 PM (GMT -6)   
GI problems have been something I have dealt with for years and years, actually even as a very young child. Pain medicines can be the worst on your stomach and intestinal tract as well, as Ginny mentioned. Even over the counter meds like ibuprofen and advil, before my diagnosis in 97' I was taking so many advil to try and get some kind of relief I ended up with a preferated ulcer in my small intestine, needless to say I had to have a bowel resection.

To this day I suffer with a lot of abdominal pain and take 40 mg a day of prilosec to try and reduce some of the effects of meds and pain. Lupus also plays havoic on the intestinal tract, when our body is inflammed that too can become inflammed. So, this is something you may want to discuss with your doctor, he will probably refer you to a GI doc for a work up to ensure nothing serious is going on.

Lupus - 1997   Fibro - 2001    Sjorens  -  2007   Raynauds  -  2008
Plaquenil, Imuran, Prednisone, Synthroid, Topomax, Effexor, Norco, Prilsec, Xanex, Elidel, Restasis

Regular Member

Date Joined May 2007
Total Posts : 475
   Posted 1/20/2009 11:13 PM (GMT -6)   
Last August I started with stomach pain. I also began losing weight. My primary ran some bloodwork and found that my "amalase" (sp?), a pancreatic enzyme was elevated. After seeing a GI doc and going through multiple tests, it was determined that I had "lupus induced pancreatitis". I am now taking aciphex (was on prilosec), and it is finally starting to settle down. Yesterday, I sought help with my overall pain level, and I started prednisone. Just a burst and I will come back off, but in the meantime it IS making my stomach hurt. But I know that is just the medicine.
I hope you have found some relief, but if not, please check with your doctor, this lupus is a strange disease.
Take care,

Dx: Lupus, sjogren's, celiac, severe allergies.
Daily Meds: Plaquenil, Zyrtec. Aciphex, Nasacort, Prozac, Ambien CR.
Daily Supplements: Calcium, B-100 Complex.
As Needed Meds: Epinephrine, Benadryl, Proventil, Xopenex, Tylenal, Darvocet, Prednisone.

Veteran Member

Date Joined Dec 2006
Total Posts : 2818
   Posted 1/21/2009 1:33 AM (GMT -6)   

Hi hun, I'm with most everyone else here. It sounds like your meds could be the culprit. But I'll go out on a limb and suggest it's the plaquenil. Only because others here have said they have problems with it. Some of them change to name brand and it doesn't seem to bother them at much. I am on aciphex as well. I hope you find and the reason soon



Possible scleroderma.  stage 4 COPD, sleep apnea, Osteoporosis,osteoarthritis
Prednisone,plaquanil400mg,azythromyacin,vicodin 4x5mg,Evista60mg, Effexor 150mg,Xanax 1.0 x3,Singular,nitro spray, provigil 200mg spirivia,aciphex,lasix ,pot.chlor.,B12 ,iNDEROL
Bear ye one another's burdens
Galatians 6:2 KJV


Forum Moderator

Date Joined Jun 2006
Total Posts : 1534
   Posted 1/21/2009 8:15 AM (GMT -6)   
Prednisone often causes heartburn and like everyone said NSAIDs can cause stomach pain, ulcers, and even bleeding. Because I take prednisone and celebrex daily, I also have to take Nexium which is a prescription antacid. I really hate nausea so I keep prescription phenegren on hand. I know it sucks to take extra medication to fight side effects, but it's better than getting an ulcer. It's good to hear from you Sweetie. Love, Butterflake
Systemic Lupus ('05), depression, diabetes, fibro, gerd, sleep apnea, hypertension, IBS 
 CellCept, plaquenil, prednisone, celebrex, lisinopril, actos, lipitor, nexeum, prozac, seroquel, wellbutrin,
actonel, tylenol arthritis, neurontin, phenegren,
flexeril, multi vit, C, flaxseed oil, acupuncture    Welcome to lupus where the strange is ordinary and nothing is normal :Donna

Veteran Member

Date Joined Mar 2006
Total Posts : 2570
   Posted 1/21/2009 11:14 AM (GMT -6)   
I hope you'll call your doctor and tell him or her what's happening with you. There's no need to suffer needlessly if there is something you can take to ease your pain. Like the other folks who have responded here, I have frequent stomach pain and discomfort and take prescription acifex to help. Let us know what your doctor says. I hope it gets better.

SLE, osteoarthritis, fibro, renauds, restless leg, hiatal hernia, double vision, migraines, costocondritis, gluten intolerance.

prednisone, plaquenil, arava, neurontin, synthroid, triamterene, actonel, tri-est, imitrex (for rare migraines), cymbalta, tricor, acifex, multivitamin, calcium w vit D, fish oil, aspirin

Regular Member

Date Joined Oct 2006
Total Posts : 281
   Posted 1/21/2009 8:40 PM (GMT -6)   
Oh man do i know what you are talking about. I have stomach pain and nausea all the time. I hate it the most I think of everything that happens with Lupus. I see my Rheumie tomorrow so I am going to mention Prilosec and see if he will give me some to see if it will help. I hate feeling sick and having stomach pain.
I hope you get some relief soon.
diagnosed with RSD in March of /03, diagnosed with Lupus in Sept./06.Thyroid Disease ,RA
Taking Methotrexate, Plaquenell, Folic Acid, Synthroid,Prednisone, Pantoloc, Singulair, Tramadol, OxyCodeine and extra Strength tylenol when needed,and Zytram.

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