medication sensitivity?

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lucysgd
Veteran Member


Date Joined Jun 2008
Total Posts : 669
   Posted 6/19/2009 10:24 AM (GMT -7)   
I just had my follow-up appt w/ my rheumy.  She's leaving my dx at UCTD, but said I may have early Lupus or most likely will show up as Lupus specifically down the road, but the longer I can remain treated on the Plaquenil and remain "undifferentiated" the better.  Amen.  I still have to get my Vitamin D levels up enough to take the Fosamax for osteoporosis.  I also have mild scoliosis and osteoarthritis.  Explains some of the back pain. 
 
My question is about being so sensitive to medication.  Antiinflammatories play havoc with my stomach, which is so annoying because they also really help the pain; Lipitor/statins put me into what feels like fibro flare, I can't take muscle relaxants, or anything with codiene; have had some bad experiences with a few ABX; antihistamines/decongestants cause heart palpitations; even my dentist gives me polarcaine without epinephrine; I couldn't tolerate Neurontin; even vitamins are GI culprits....you get the picture.   So grateful I have no problem with the Plaquenil - but I resisted that too long for fear of side effects.
 
Rheumy gave me Rx for Lidocaine patches for pain (I asked for something topical).  Does anyone else have experience with the lidocaine patches or this sensitivity issue?  Trying to figure out if this is a by-product of the autoimmune problem, or the fibro, or just an unrelated fluke.   Rheumy kind of shrugged at that question, but warned me this could put me in a real trouble spot at some point. 
 
Thanks for any help/comments.  Hope you are having a good day!
Lucy

diagnoses:  mono 1972; postviral CFS 1997; fibro 1998;  UCTD (dx limbo) 2007
meds: Plaquenil 400 mg, occasional low dose xanax for sleep aid, artificial tears w/ ointment at night, Advil/aspirin prn
 
 


Anne092
Regular Member


Date Joined Nov 2008
Total Posts : 52
   Posted 6/19/2009 2:23 PM (GMT -7)   

I am new to lupus.  But I to are extra senstive to meds.  I would love to know if anyone else have trouble with side effects.  I am just going off a week of antibotics and my stomach is giving me so much trouble.  I guess there is nothing we can do about it. 

 

Anne


mypearl
Regular Member


Date Joined Aug 2005
Total Posts : 215
   Posted 6/19/2009 9:03 PM (GMT -7)   
Lets see here:
 
pcn = anaphlaxix
sulfa = angio edema
keflex = angio edema
lovenox = fever of 105
methotrexate = pulmonitis
all beta blockers = pulmonitis
arava = hypertension 200/110
banana's = anaphlaxis
bee's = anaphlaxis
 
I know Im missing something. I too get scared when put on anything. I am only able to take 5mg of prednisone 2 times a day. Any more and I go nuts. I understand where your coming from. Sorry, and I think its probably a autoimmune thing. I do know that many lupies have an allergy to sulfa.
sle 92, fibromyalgia 95, t4 fracture 06, hyperthyroid with nodules 05, pernisious anemia 04,
? lupus vasculitis lungs, osteoporosis, c3-4 t1 herniated disks 00, gerd, depression
APLS, hyperthyroid, thyroiditis, complex thyroid nodules, asthma, stiff heart with 4 valve regurg., hemolytic anemia, supraventricular tachycardia
meds:prednisone, plaquinil, imuran, hydrocodone, flexeril, ibprofen, asa, fosamax, prilosec,


Barbara Lee
Veteran Member


Date Joined Sep 2003
Total Posts : 2889
   Posted 6/20/2009 7:01 AM (GMT -7)   

Hi Lucy:

I"m sorry that you have such problems taking medications.  It certainly complicates things, I don't have the problem that you do with taking meds.  I did want to reply tho I've used the lidocaine patches on my back.  I had no reactions of skin irratation like I do with the fentanyl patches.  Those caused me to break out in a rash around the edges of the patch, so i was told to stop taking them. 

I'd use the lidocaine patches at night and sleep in them and the seems to help somewhat with my pain.  I did not use them during the day, so I'm sorry I can't offer up any information t o you.  Here's wishing you the best with your meds and I hope that you start to have less painl

Hugs,

Barbara


dx fibro, SLE, glaucoma, cateracts, bells palsy, depression, migraine headaches, gastreopaersis, chronic anemia, RA,MDS (Blood Cancer). Tons of meds.


lucysgd
Veteran Member


Date Joined Jun 2008
Total Posts : 669
   Posted 6/21/2009 9:47 PM (GMT -7)   

Thanks Pearl, Anne and Barbara for your responses.  This sensitivity thing seems to have come on with the fibro (quite some time ago) and has increased over the last couple of years.  I'm going to pass along the lidocaine info to my mother - she has some serious osteoarthritis and can't take nsaids because of a bleeding disorder - this may help her as well, especially at night 

Lucy


diagnoses:  mono 1972; postviral CFS 1997; fibro 1998;  UCTD (dx limbo) 2007
meds: Plaquenil 400 mg, occasional low dose xanax for sleep aid, artificial tears w/ ointment at night, Advil/aspirin prn
 
 


sjkly
Veteran Member


Date Joined Dec 2007
Total Posts : 2113
   Posted 6/22/2009 5:54 PM (GMT -7)   
Have you been tested for cholinestrase deficency-it runs in my family and I have all the exact same med sensitivites that you do. No antihystimes, decongestents-some antacids (the ones that are hystimine blockers) etc. Really weird reactions to codine.

I can take plaq, mtx and I take singulair for alergies with no side effects at all.

cured4real?
Veteran Member


Date Joined Dec 2005
Total Posts : 1944
   Posted 6/22/2009 7:18 PM (GMT -7)   
Lucy--
I can't take most things, cyp3A4 inhibitors are the primary problems. I have problems with some anticholinergenics and GABA inhibiting drugs (neurontin, lyrica, gabatril) too. My problems often only occur after a month or so of use, but I get bad sideeffects during the entire time. The rash usually starts after a month or so. Some meds are so bad I can't tolerate for more than a few days. My doc explained that in my case my liver is like a sieve, a filter, and mine is so full of fat that meds with large or complex molecules cannot fit through the decreased holes in the filter and the drugs back up in my system. My body views it as toxic, then the fun starts.

I do better on choliinergenic and pro GABA drugs. Apparently I need more choline and GABA, not less.

I found amazingly good info on a meds to avoid list for porphyria. I don't know if there is some component of porphyria to some autoimmune diseases, but it read like a list of my allergies. It is a good resource for over the counter and other substances, to check to see if they increase sun sensitivity, which we all seem to have.

My mom has ulcerative colitis and is allergic to nearly everything, including aloe and lanolin. Her allergies seemed to accumulate with age.

Allergc reactions are caused by histamines, origin in the liver. Sparing your liver from unnecessary damage can help with reducing the chances of developing new allergies for me. I don't know if this helps but I hope you can find a balance. Just make sure you check and take care of your liver yourself, too. Many docs feel liver damage is an appropriate sacrifice for quality of life, but with a little more effort and research, they often can find a better compromise.
Love, Marji
Ills--Sjogrens-Lupus cond., AI polygland. dysfunction 2, hyper/hypopigment, scoliosis,kyphosis,stenosis, deg.,O.A.,spine surgeries, salivary/lymphectomies, NASH, COPD, RLS, UT/GI bleeds, hystero, brain/nerve damage,TB
Meds--INH,Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, HRT and Lidocaine patchs, Voltaren gel, Klonopin, Vicodin, Restasis, Albuterol, steroids

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