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New Member

Date Joined Jun 2009
Total Posts : 15
   Posted 6/30/2009 9:57 PM (GMT -6)   
Are the sm and rnp antibodies found in anything besides MCTD?  I can't find much info on thses and much of the info I have found, I don't understand.  Any thoughts? 

Veteran Member

Date Joined Dec 2005
Total Posts : 1944
   Posted 7/1/2009 10:15 PM (GMT -6)   
I don' know about RNP or all diseases but they keep checking my antiSM antibodies because of autoimmune liver disease they thinkI might have due to the severity of my NASH, the heredity of it, and othersymptoms. The SM are the only one of a bunch of them I don't have. labtestsonline should give you a description of the diseases they may be involved in.

I googled RNP and liver and it and the SM antibodies are common in chronic liver disorders per

I have LKMs, P-ANCA, ss-dna, ds-dna (too low to be positive), and some others I don't remember. I always have elevated ANA. SM are the only ones I have absolutely zero of. And my liver disease is significant, go figure.

You might read up on PBC and some other autoimmune liver diseases. Steroids put them into remission and damage get better in remission because the liver heals but they have to know you have it to properly treat you if it flares up. Should you be interested, I can direct you to the only place I know that has an autoimmune liver disease forum and lots of info. I was told it is treatable (unlike my liver condition) but they had to be sure whether you have it and not some kind of infection because the steroids make infections worse. Dietary things can help as well and sometimes additional drugs are needed.That being said, I would talk to the doc about seeing a hepatologist, not just a good GI doc, for a liver eval.

While I may allow my rheumatologist to deal with tx if they suggest it because they know most about steroids, I would definitely want to see a hepatologst for a firm dx even if they don't suggest it, after reading the article noted above. They can do an abdominal ultrasound and tell alot. If this is a problem, you may find yourself feeling a whole lot better once it is treated and you get a chance to heal. Also, they may change your daily meds to alternate drugs that cause less liver damage and there are definite plusses to that on the energy side sometimes.

Feel free to email me, I will put my address in my profile. I will pray that it is just an incidental finding, that you are not troubled by it, and that you get the care you need and proper dxs. It sounds like your docs are good.

Take care and let me know how it goes. My dad is 72 and has compensated cirrhosis and has been sick for like 30 years and runs five miles and lives a completely normal life. I have been sick for 17 but I was misdiagnosed and messed up. Having autoimmune disease along with it certainly doesn't help things but with the proper testing and dosing of steroids for ai liver, you can experience remissions, sometimes really really long ones if youtake care of yourself.
Love, Marji
Ills--Sjogrens-Lupus cond., AI polygland. dysfunction 2, hyper/hypopigment, scoliosis,kyphosis,stenosis, deg.,O.A.,spine surgeries, salivary/lymphectomies, NASH, COPD, RLS, UT/GI bleeds, hystero, brain/nerve damage,TB
Meds--INH,Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, HRT and Lidocaine patchs, Voltaren gel, Klonopin, Vicodin, Restasis, Albuterol, steroids

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