I've been taking Mtx for about two years now. I know how you feel and I definitely prepared for the worst when I first took it. Made sure I had seven up, soup, ginger cookies on hand for nausea. But, guess what? I have never really gotten sick in all this time. I usually take it Friday nights so I can rest on the weekends with it. I have had maybe 3 or 4 times when I can say I experienced a little bit of nausea. It wasn't bad enough to really make me sick though. On the good side, I can say I defiitely feel better taking it and can tell when I haven't.
I hope this helps calm some of the uneasiness you are experiencing. Let us know how it goes.
I did not read everyone else's post, but I wanted to quickly let you know that I, also, was very scared to try mtx. When I finally made the decision to do it, however, it made a signficiant difference in just a few months. Now, i can't imagine what I would feel like without it. I was started out on 7.5 mg/week (which is low), but I didn't start feeling anything until it was raised to 15mg/week. Starting you at 10mg/week is probably a good idea. When I first started taking it, I found that it made me a tad bit queasy (honestly, not as bad as plaquenil did), and very tired for a day or two after taking it. AFter being on it for a few months, however, I didn't experience any side effects. I also take enbrel for my joints, but if I had to choose between them I would go with mtx hands-down.
It's not as scary a drug as it's made out to be (IMHO).
Best of luck on your decision,
Best of luck, Hippi! I really understand the anxiety issue with a new med. I put off taking Plaquenil for so long because of it - and turns out my fears did not materialize. Hope the same happens for you and you get all the benefits.