ANA POSITIVE all other IA tests neg

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New Member

Date Joined Sep 2009
Total Posts : 1
   Posted 9/8/2009 4:54 PM (GMT -6)   

about 3 years ago i noticed a "rash" on my foot but over the past year it has become darker purple and started moving up my leg.  When you press the rash on my feet it goes away. I Have been to Family Doc, Dermatologist and Rheumatologist.  The "rash" seems to be inflamed capillaries according to the Dermatologist and the blood work the Family Dr and Rheumatologist both came back with a positive ANA but negative for everything else.  I was wandering has anyone ever seen the type of "rash" None of the dr's seem to know what it is since it is not IA (according to the blood work).  I feel like I keep getting the run around.


Is it normal to have a positive ANA test and negative for all other AI tests?? 

Veteran Member

Date Joined Jun 2008
Total Posts : 669
   Posted 9/8/2009 6:59 PM (GMT -6)   

Hello Ent - Welcome! You will find quite a few of us here who have the positive ANA but no other specific AI marker.  I am one of them with a diagnosis of UCTD (undifferentiated Connective tissue disease).  It is true that a positive ANA by itself does not necessarily identify an autoimmune illness, and it's possible to be perfectly healthy with a positive result.  However, a persistant and relatively high and/or climbing ANA along with symptoms is a pretty strong indicator that something AI is going on. 

Do you have other symptoms?  Generally, treatment to control your symptoms is more important than a specific diagnosis.  A rheumatologist is the doctor to help you with autoimmune issues, but if yours isn't listening, I would look for another one.   Finding one who will work with you may take a bit of looking.

There are links on here with helpful information about Lupus. is a great place to start.  And I'm sure someone else will be along to comment as well.  Asking questions is important.  This is a great place to start.

Good luck!


diagnoses:  mono 1972; postviral CFS 1997; fibro 1998; UCTD & osteoporosis 2007; celiac 2009
meds: Plaquenil 400 mg, occasional low dose xanax for sleep aid, artificial tears w/ ointment at night, Advil/aspirin prn and lots of vitamins

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