ANA - positive to negative

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lucysgd
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Date Joined Jun 2008
Total Posts : 669
   Posted 10/29/2009 7:41 PM (GMT -7)   
Hi Everyone - I just had follow up labs after going gluten free and beginning a vitamin regimen that includes cinnamon and fish oil.  After only 6 weeks, and barely taking half of the supplement "prescription",  because I started having reflux, etc. along with flare and had to back off the vitamins numerous times - nevertheless my cholesterol profile improved tremendously (triglycerides alone came down a whopping 400 points!)  My Vit D improved from 17 to 26 (I barely took any Vit D) a high parathyroid level returned to a normal range, and my ANA was negative for the first time in 3 years.  In May it was still considerably elevated.   Was it the gluten free diet?  The vitamins?  Not entirely sure yet, and to be fair - I've been on Plaquenil since last December. 
 
The doctor cites the malabsorption due to the celiac as the main reason for my osteoporosis and what he called "adult rickets", and my bad cholesterol profile, especially triglycerides comes from Vit B deficiency.  I've never been able to stay on a statin drug - all caused major side effects.  I've had less aches and pains since taking triple strength fish oil.  Cognition is slightly better.  Still get fatigued and seem to have flares involving my stomach every 1 - 2 weeks since starting all of this, so I'm investigating and trying to rule out possible causes of that (one of which might be the pharmacy's switch to a different manufacturer of my generic Plaquenil that occurred at the same time).   But in general I am really encouraged.  I've been doing a lot of reading and information gathering regarding celiac disease and autoimmune disease and there are so many links!  I'm actually shocked that in 3 years my rheumatologist never explored this possibility.
 
This doctor also cites the overabundance of Omega 6 in our diets, especially in relation to the low Omega 3's.  So he encourages no vegetable oils, (butter is preferable), nuts, or chicken (they break down the corn diet in such a way that it loads us up with Omega 6) for starters.  Fish and beef are preferred.  I won't get into it any further - but I did want to say that it seems diet may play a bigger role than previously considered by most doctors in the formation and progression of autoimmune disease.  At least it's something I'm going to continue to pursue.  Maybe my ANA went negative because of the Plaquenil.....but with the other changes, I'm inclined to believe it had quite a lot, if not everything to do with the dietary changes. 
 
There was one negative to all the improved bloodwork, and that is that my CRP actually increased (doubled, really).  Will be checking with the doc on that.  If you google "nutrigenomic medicine" - or just "Celiac and autoimmune disease" you'll have quite a lot of reading to do.  I would encourage anyone with autoimmune issues (or diagnosed children) to pursue the possible connections.  All this is just MHO  -
 
Lucy
 
 
diagnoses:  mono 1972; postviral CFS 1997; fibro 1998; UCTD & osteoporosis 2007; celiac 2009
meds: Plaquenil 400 mg, occasional low dose xanax for sleep aid, artificial tears w/ ointment at night, Advil/aspirin prn and lots of vitamins
 
 


PattyLatty
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Date Joined Mar 2006
Total Posts : 2570
   Posted 10/30/2009 8:46 AM (GMT -7)   
This is great news Lucy, and food for thought for all of us. I've been flaring and feeling awful so it might be time to get back on a gluten free diet. I know it works.

Good for you.
SLE, fibro, renauds, restless leg, hiatal hernia, double vision, migraines, costocondritis.

prednisone, plaquenil, leflunomide, neurontin, synthroid, triamterene, actonel, niaspan, tri-est, cymbalta, tricor, acifex


lucysgd
Veteran Member


Date Joined Jun 2008
Total Posts : 669
   Posted 10/30/2009 9:02 AM (GMT -7)   
Thanks Pat - I hope you will start feeling better very soon!
Lucy
diagnoses:  mono 1972; postviral CFS 1997; fibro 1998; UCTD & osteoporosis 2007; celiac 2009
meds: Plaquenil 400 mg, occasional low dose xanax for sleep aid, artificial tears w/ ointment at night, Advil/aspirin prn and lots of vitamins
 
 


jhmom
Veteran Member


Date Joined Oct 2004
Total Posts : 2244
   Posted 10/30/2009 6:05 PM (GMT -7)   
Hi Lucy, I am glad you had some improvement in your labs, that is awesome!!!

Not long after I started on Plaq (which was 9 months after going GF) my ANA went down too so I would bet it is the Plaq but eating healthier is always a plus and encouraged! Keep up the good work! Take care
Stacie
Trust in the Lord with all thine heart, and lean not unto thine own understanding ~ Proverbs 3:5 ~

DX: Lupus, Sjogrens, Raynaud's, Hashimoto's and Celiac Disease
RX: Imuran, Plaquenil, Methotrexate, Flexeril, Piroxicam, Levoxyl, Folic Acid, Folgard OS (B12), Vitamin D-50,000 IU, Tramadol (as needed) and magic mouthwash (for mouth sores)


lucysgd
Veteran Member


Date Joined Jun 2008
Total Posts : 669
   Posted 11/1/2009 5:33 PM (GMT -7)   

Thanks, Stacie.   In an effort to figure out the stomach/flare culprit I stopped taking my Plaquenil last Monday - and I went all week without a stomach flare, even with taking vitamins and consuming dairy.  However, I woke up this morning with a sore throat and low grade fever, red bumps on my face, extra painful places and a double heap of fatigue.  I switched to brand name Plaquenil when I renewed my Rx last week - so I took the first dose of that tonight.  Hoping my stomach will remain quiet and these other symptoms will go away. 

Did your ANA ever go negative?  I have read that it doesn't necessarily correspond to disease activity......but it must represent something?

Lucy


diagnoses:  mono 1972; postviral CFS 1997; fibro 1998; UCTD & osteoporosis 2007; celiac 2009
meds: Plaquenil 400 mg, occasional low dose xanax for sleep aid, artificial tears w/ ointment at night, Advil/aspirin prn and lots of vitamins
 
 


jhmom
Veteran Member


Date Joined Oct 2004
Total Posts : 2244
   Posted 11/1/2009 5:51 PM (GMT -7)   
Hi Lucy, I hope the brand plaq works better for you! Plaq can be rough on the stomach, my rheumy started me off very slowly so don't give up on it!

The first ANA I had was 1:640 (in 2004) then a year later after being on Plaq it was 1:80 and hasn't been checked since then. It's not something my rheumy monitors as you are right it is no indication of disease activity. Let us know how you tolerate the plaq.
Stacie
Trust in the Lord with all thine heart, and lean not unto thine own understanding ~ Proverbs 3:5 ~

DX: Lupus, Sjogrens, Raynaud's, Hashimoto's and Celiac Disease
RX: Imuran, Plaquenil, Methotrexate, Flexeril, Piroxicam, Levoxyl, Folic Acid, Folgard OS (B12), Vitamin D-50,000 IU, Tramadol (as needed) and magic mouthwash (for mouth sores)


Lynnwood
Forum Moderator


Date Joined May 2005
Total Posts : 7019
   Posted 11/1/2009 9:48 PM (GMT -7)   
Yes, ANA can "go negative". I haven't had any ANA for over a year now, after about 8 positive years. My rheumy says my lupus is "quiet" -- they don't use the word "remission".

Overall, thou, it's still a mystery to all!
Lynnwood, Lupus & Sjogren's Moderator
"Life is far too important to be taken seriously" - Oscar Wilde

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