Should I be worried with ANA alone?

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peacesoul
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Date Joined Jan 2007
Total Posts : 2446
   Posted 2/26/2010 1:05 PM (GMT -7)   
Hi everyone. It's been a while since Ive been here.

I was dx with lupus in 07 and 6 months later with lyme. I was being treated for both.

I stopped all treatment 18 months ago and my tests were always showing active "illness" but just got my results back today and my ANA is 1.32 down from 1.64 and no sed rate, no action on C3 & C4, thyroid normal etc.  
 
Most of my symptoms are now gone or I have 1 or 2 lingering but the rheum is still worried about my ANA since it was 1.64 a few months back. He knows I will not take meds, but he seemed worried.

Any reason to worry seeing that the ANA is not conclusive?

Lynnwood
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Date Joined May 2005
Total Posts : 7020
   Posted 2/26/2010 1:23 PM (GMT -7)   
Since we know, as you said, that the ANA alone is not necessarily a diagnosis for anything, but instead indicates any autoimmune disease...I wouldn't worry about it.

So glad to hear you are feeling better and that most of your symptoms are gone. I use symptoms as the main factor in deciding how active I think my disease is....it's a lot cheaper than having blood tests all the time!!

And, overall, remember that 1:64 is a very low positive ANA...most doctors don't even consider it all that indicative until the titer gets to 1:320 or 1:640.

Good to see you again,
Lynnwood, Lupus & Sjogren's Moderator
"Life is far too important to be taken seriously" - Oscar Wilde


okie
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Date Joined Dec 2006
Total Posts : 2818
   Posted 2/27/2010 1:17 AM (GMT -7)   
Hey there! yep it's been a while. You would probably do well to ask him what his/ her problem is. You knw there are times when your ANA goes postive to neg and back again somtimes because that's what the meds are for is to fight your battles.
Like Lynnwood said even though it isn't easy try not to worry. You may very well have many ups and downs throughout your life. so if you worry with every change it can't be good for ya. Just try to keep records and stay aware of what your body is doing. If your doctor is not answering your questions get a new doctor. there is nothing wrong with a second opinion. I'm not suggesting you look for somthing the isn't there but staying on op of your symptoms and blood count is very important. I would ask how often he wants you to get your blood checked. It would be good to get checked out at least a couple times a year even more if you aren't feeling well.
Good to see you!
hugs
carol
Lupus lung, maybe, scleraderma maybe, another A/I maybe, Hang nail maybe. COPD
meds to many to fit in my 10 lines. but last count was 28.

 Jesus loves you and so do I!
 
 


peacesoul
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Date Joined Jan 2007
Total Posts : 2446
   Posted 3/1/2010 7:17 AM (GMT -7)   
Hi, thanks for the replies and thanks for the welcome (back) :-)

I'm not worried terribly but when he said my ANA was the highest titer, there can be or is some tissue damage.
My doc asks me to get my blood tested every 6 months.

Lynn, my titer was the highest which is 1.64. 1.8 is the lowest

from the lupus of canada sitte: "1:64 is considered very high and tissue damage is imminent"

This is why I was asking. All other tests were ok but this.

Lynnwood
Forum Moderator


Date Joined May 2005
Total Posts : 7020
   Posted 3/1/2010 8:52 AM (GMT -7)   
They must be doing a different kind of test reference wherever you are. The test they use here can go at least as high as 1:1280, and 1:32 is the lowest positive. Weird.
Lynnwood, Lupus & Sjogren's Moderator
"Life is far too important to be taken seriously" - Oscar Wilde


peacesoul
Veteran Member


Date Joined Jan 2007
Total Posts : 2446
   Posted 3/2/2010 7:31 AM (GMT -7)   
hi, I found this
 
Now I'm confused. Do the US and Canada use two different titers?
 

A negative ANA is any number LESS than 1:80 (this is "pronounced" one to 80 parts). (Plasma was diluted 1 part plasma with 8 parts diluting solution.)

Since each dilution involves doubling the amount of test fluid, it is not surprising that titers increase rapidly. In fact, the difference between titers of 1:160 and 1:320 is only a single dilution. And it doesn't necessarily represent a major difference in disease activity.

Lower than 1:20 is considered a negative result.
1:80 is considered a "low positive" and more tests should be ordered. 95% of people with 1:80 ANA do not have Lupus.
1:16 is considered positive and if SED rates and Complement tests are positive, Lupus is considered.
1:32 is a definite positive and mean the disease is active.
1:64 is considered very high and tissue damage is imminent


tibby2
Regular Member


Date Joined Mar 2010
Total Posts : 20
   Posted 4/3/2010 11:29 PM (GMT -7)   
Hi
I'm from Australia. I think you'll find the titer readings are the same worldwide
The confusion is coming from the way it is being said/written :

1:20 OR 1:2
1:40 OR 1:4
1:80 OR 1:8
1:160 OR 1:16
1:320 OR 1:32 and so on

each time the plasma is diluted it doubles the number. As I understand it, some people don't put the "0" on the end but mean the same thing. It makes it very confusing.

If you think of it logically - if the dilution is doubled every time there is no way you could have a reading of 1:32 or 1:64. After all it would be - 20, 40, 80, 160, 320, 640, 1280, 2560 etc
 
(I had to come back and correct what I wrote - having a bad "concentration" day   lol   I had done exactly what I was talking about and NOT put the zeroes on the end of the last lot of numbers)  idea

Post Edited (tibby2) : 4/4/2010 4:57:16 PM (GMT-6)


lucysgd
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Date Joined Jun 2008
Total Posts : 669
   Posted 4/4/2010 4:12 PM (GMT -7)   

I had not heard anything about the ANA titre indicating tissue damage in the higher ranges.  Anybody else?

Lucy


diagnoses:  mono 1972; postviral CFS 1997; fibro 1998; UCTD & osteoporosis 2007; celiac 2009
meds: Plaquenil 400 mg, occasional low dose xanax for sleep aid, artificial tears w/ ointment at night, Advil/aspirin prn and lots of vitamins
 
 


Lynnwood
Forum Moderator


Date Joined May 2005
Total Posts : 7020
   Posted 4/4/2010 8:33 PM (GMT -7)   
lucysgd said...
I had not heard anything about the ANA titre indicating tissue damage in the higher ranges. Anybody else?
Lucy


I've never heard that, and I've been around here quite a while...
Lynnwood, Lupus & Sjogren's Moderator
"Life is far too important to be taken seriously" - Oscar Wilde

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