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SmurfyShadow
Veteran Member


Date Joined Dec 2008
Total Posts : 2386
   Posted 7/23/2010 10:50 PM (GMT -7)   
I'm being switched to methotrexate from immuran. Should I be aware of anything about methotrexate?
 
Smurfy Shadow/Desirèe 
DX: Wegener's Disease, Migraines, Diabetese Type II, PCOS, Lactose Intolerant, Benign Heart Murmer, Depression, Asthma, Asperger's Syndrome, Necrotizing Gramultous Inflamation in eye, A.D.D., Acid Reflux, Tumor Behind the Eye, Carpal Tunnel, Fibromyolgia, Clasterphobic, Arthritis, Anxiety
Medications:  Tri Nessa, Percocet, Metformin, Prednisone, Cingulair, Albuterol, Pro-Air, Morphine, Rolaids, Zofran, Compuzeen, Refresh Plus Eye Drops, Percocet, Immuran, Alvesco, Allerga, Gabapentin, Visteral  PRN: Epi-Pen, Albuterol Nebulizer, Benedryl Undergoing Chemotherapy Taking Lorazepam (Ativan) For MRIs and Anxiety, Surpressed Immune Sytem


crazykitty
Veteran Member


Date Joined Jul 2009
Total Posts : 4796
   Posted 7/24/2010 12:03 AM (GMT -7)   
Hi Desiree, I was swithched to Methotrexate from Imuran and have been lucky
not to have any bad side effects. I have been on it a year and only am on a low
dosage. I take 10 mgs 1x weekly. Methotrexate comes with warnings and side
effects, just as Imuran. Initially your bloodwork is checked often, usually CBC
and CMP. Now mine is checked every 9 weeks. I take it for MCTD.

Hugs, Robin
Fibromyalgia, MCTD (Lupus, Scleroderma & RA) Raynaud's, Osteoporosis,
Osteoarthritis, Degenerative Disc Disease, Migraines, and Hypertension
Prescription Meds: Savella, Cyclobenzaprine, Methotrexate, Diltiazem, Boniva,
Folic Acid.  OTC Meds: Multi-vitamin. Vit, D, Vitamin B12 & calciim supplements
 
 


aimsgirl16
Forum Moderator


Date Joined Jun 2008
Total Posts : 1469
   Posted 7/24/2010 5:39 AM (GMT -7)   
I was about to try MTX a few months ago until my nephrologist said absolutly not! But I remeber very well the MTX talk my rhuemy gave me...
1. since i have a sensative stomach we were going to do the shot instead of pills (maybe something to consider)2. can't have a baby while taking MTX (very harmful)3. Should help joints tremoundsly 4. not good on my already bad kidneys5. Getting labs checked monthly (which is probably normal, I think)6. and like all the other meds, weakened immune system!So no, i have never taken it but hope this helps a little. Do you have any certain questions about MTX or are you primarly looking for experieces?



Hope this medicine does the trick for ya and doesnt give you near as many problems as the Imuran has been known to do!!!

crazykitty
Veteran Member


Date Joined Jul 2009
Total Posts : 4796
   Posted 7/24/2010 9:12 AM (GMT -7)   
I forgot to add that folic acid is usually prescribed when taking methotrexate. It
helps prevent some side effects. In the past, I do remember my liver enzymes
being elevated a couple times but they returned to a normal level.

Hugs, Robin
Fibromyalgia, MCTD (Lupus, Scleroderma & RA) Raynaud's, Osteoporosis,
Osteoarthritis, Degenerative Disc Disease, Migraines, and Hypertension
Prescription Meds: Savella, Cyclobenzaprine, Methotrexate, Diltiazem, Boniva,
Folic Acid.  OTC Meds: Multi-vitamin. Vit, D, Vitamin B12 & calciim supplements
 
 


SmurfyShadow
Veteran Member


Date Joined Dec 2008
Total Posts : 2386
   Posted 7/25/2010 12:23 AM (GMT -7)   
Well I picked the shots, because I had such a horrid time with immuran. I told the doctor "Im because we will know faster if I can do this medication or not then". On immuran I had the naseau, vomiting so fierce I vomit bile, diahrea with blood like a menstraution cycle, dehydration, and I go into shock because of how much fluids I lose and I have to get IV therapy for hydration.

I dont want to be as sick. And i read somewhere that methotrexate can cause people to hallicunate and go into comas and die. So I'm more so asking what sould I look out for to protect myself. What are the normal side effects? What precautions can I take to make sure I dont get so sick? How the heckers do I give myself the shot as well I'm too chicken? Funny, I stick needles in people all day long every day but when it comes time to sticking me I get cold feet.
 
Smurfy Shadow/Desirèe 
DX: Wegener's Disease, Migraines, Diabetese Type II, PCOS, Lactose Intolerant, Benign Heart Murmer, Depression, Asthma, Asperger's Syndrome, Necrotizing Gramultous Inflamation in eye, A.D.D., Acid Reflux, Tumor Behind the Eye, Carpal Tunnel, Fibromyolgia, Clasterphobic, Arthritis, Anxiety
Medications:  Tri Nessa, Percocet, Metformin, Prednisone, Cingulair, Albuterol, Pro-Air, Morphine, Rolaids, Zofran, Compuzeen, Refresh Plus Eye Drops, Percocet, Immuran, Alvesco, Allerga, Gabapentin, Visteral  PRN: Epi-Pen, Albuterol Nebulizer, Benedryl Undergoing Chemotherapy Taking Lorazepam (Ativan) For MRIs and Anxiety, Surpressed Immune Sytem


aimsgirl16
Forum Moderator


Date Joined Jun 2008
Total Posts : 1469
   Posted 7/25/2010 8:16 AM (GMT -7)   
I am not 100 % sure but I think the major side effects are more for the higher doses of MTX, the ones used for cancer patients. Since I believe the highest dose you will probably get is 15 mg I do not think the side effects you are talking about will come into play. Also, you should get yoru first shot at the doctors office and they should teach you how to do it correctly (EVEN IF YOU STICK PEOPLE ALL DAY) and they can explain to you what you need to watch for. This is also a question that should be asked to your doctor!

I understand about the sticking thing. I am fine when it comes to pills but the whole idea of it getting in my body and absorb quicker doesnt stand to well with me. HAHA

SmurfyShadow
Veteran Member


Date Joined Dec 2008
Total Posts : 2386
   Posted 7/25/2010 11:37 AM (GMT -7)   
I think I'm on one of those "high doses". I will be taking .2 less of 1000mg which is actually .8 ml I had to google a conversion as it is to find out how much mg I would take. I only got 1ml conversion from google as 1000mg. If my math is right I'll be doing 800mg. Oh this is a weekly dose to. I'm supposed to shoot myself once a week. I have a tumor hon, thats why I'm probably high dosed.
 
Smurfy Shadow/Desirèe 
DX: Wegener's Disease, Migraines, Diabetese Type II, PCOS, Lactose Intolerant, Benign Heart Murmer, Depression, Asthma, Asperger's Syndrome, Necrotizing Gramultous Inflamation in eye, A.D.D., Acid Reflux, Tumor Behind the Eye, Carpal Tunnel, Fibromyolgia, Clasterphobic, Arthritis, Anxiety
Medications:  Tri Nessa, Percocet, Metformin, Prednisone, Cingulair, Albuterol, Pro-Air, Morphine, Rolaids, Zofran, Compuzeen, Refresh Plus Eye Drops, Percocet, Immuran, Alvesco, Allerga, Gabapentin, Visteral  PRN: Epi-Pen, Albuterol Nebulizer, Benedryl Undergoing Chemotherapy Taking Lorazepam (Ativan) For MRIs and Anxiety, Surpressed Immune Sytem


Lynnwood
Forum Moderator


Date Joined May 2005
Total Posts : 7019
   Posted 7/25/2010 1:31 PM (GMT -7)   
I think your "google conversion" is totally incorrect.

Liquid ml of a medication simply can't be straight-forwardly converted to pill form mg's, especially without knowing the saturation level of the liquid form.

Normal dosages are in the range of 15-20 mg per week, in pill form. From doing some reseach I see that a 1 ml injection is a 20mg dose.

High dosages of >500 mg must be given by 24-hour infusion, followed by 2-3 days of multiple leucovorin doses otherwise they are *toxic* doses.

My reference is
www.uptodate.com/patients/content/topic.do?topicKey=~q9ZfU8NavINxmK

In any case, hope you feel better soonest,
Lynnwood, Lupus & Sjogren's Moderator
"Life is far too important to be taken seriously" - Oscar Wilde


SmurfyShadow
Veteran Member


Date Joined Dec 2008
Total Posts : 2386
   Posted 7/26/2010 11:04 PM (GMT -7)   
OH wow, thank you
 
Smurfy Shadow/Desirèe 
DX: Wegener's Disease, Migraines, Diabetese Type II, PCOS, Lactose Intolerant, Benign Heart Murmer, Depression, Asthma, Asperger's Syndrome, Necrotizing Gramultous Inflamation in eye, A.D.D., Acid Reflux, Tumor Behind the Eye, Carpal Tunnel, Fibromyolgia, Clasterphobic, Arthritis, Anxiety
Medications:  Tri Nessa, Percocet, Metformin, Prednisone, Cingulair, Albuterol, Pro-Air, Morphine, Rolaids, Zofran, Compuzeen, Refresh Plus Eye Drops, Percocet, Immuran, Alvesco, Allerga, Gabapentin, Visteral  PRN: Epi-Pen, Albuterol Nebulizer, Benedryl Undergoing Chemotherapy Taking Lorazepam (Ativan) For MRIs and Anxiety, Surpressed Immune Sytem

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