Positive ANA w/ Anti-SM antibodies?

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Veteran Member

Date Joined Aug 2007
Total Posts : 4389
   Posted 7/28/2010 6:34 PM (GMT -6)   
Does anyone here know the specific significance of anti-sm antibodies?  I don't have a titer for the total ANA (which I thought was strange...) but they say the anti-sm antibodies are 1.2 with normal <1.0.  Not terribly elevated, but elevated nonetheless.  I have a history of positive ANA (1:360 is my highest titer that i know of) but always with negative splits (specific antibodies) until now.  So I don't know what to make of the anti-sm antibodies, and my brain isn't up to doing the extensive digging around online that I used to be able to do so easily to find out more about what this means.  So I'm here asking you experts instead tongue
Chronic Lyme Disease, Bartonella (clinical dx only), Gluten & Sulfite Sensitivity, Many Food/Inhalant/Medication/Chemical Allergies & Intolerances, Asthma, Gut issues (dysmotility, non-specific inflammation), UCTD ("Secondary Lupus-Like Syndrome"), Osteoporosis, etc.; G-Tube; TPN via PICC (trying again to wean off the TPN).
Meds:  IV Cipro, Heparin (to flush PICC line), Singulair, Claritin, Domperidone, Colloidal Silver, probiotics, digestive enzymes, Milk Thistle & other liver support herbs, Magnesium, homeopathy.

New Member

Date Joined Jul 2010
Total Posts : 1
   Posted 7/30/2010 11:49 AM (GMT -6)   
Razzle, thank God I found your post because I have the same questions and results as you! I have had numerous problems and symptoms of lupus for over 3 years now, but was diagnosed with acute hoshimoto's in high school which resolved itself.
My blood work came back ANA direct positive (no values given). After the initial meeting with a rheumatologist he said that the ANA is not specific and he needed to do the antibody test, especially since the hoshimoto could give a false positive. All antibodies came back negative, except, just like your test, the anti-sm came back 1.2. Ironically my ANA direct was still positive, but the ANA IFA was negative. Therefore, my rheumatologist basically told me that nothing was wrong and sent me on my way. He explained that the anti-sm and ANA direct was indeed a "false positive" by the hoshimotos which he "confirmed" by the ANA IFA being negative. The dr also stated that the anti-sm was too low to treat anyway and disregarded it.
But like you stated, the anti-sm is still positive and elevated. Even if its weakly positive- its still positive. Seriously, can a pregnancy test be "weakly positive"..lol..I'm confused by it all too. 
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