I was dx by my Md with Mixed Connective Tissue Disease. The last couple of months my ANA levels keep getting worse. Now, since last month, my liver enzymes have gone crazy as well. I don't know for sure what is going on but I am sure by what the dr said on the phone it isn't good. I have had near liver failure twoce in my life. I am not a drinker and I take pretty good care of myself and I am not on a lot of meds for sometime now. I treat the symptoms and nothing more. I deal with a lot of the pain and discomforts to this point. Now the info I found today, cause I have so many questions, I hadn't ever seen before on any of my searches. My ANA pattern is Speckled. SLE, MCTD, Sjogrens, and a couple other similiar diseases are listed on most searches. Today I also found that with Speckles and elevated liver enzymes there is a monster called Autoimmune Heptitis. Hope that there isn't anyone in this boat but if you have similiar labs don't let the dr overlook this especially if you have had a surgery with extended hospital stays. Night all. Hope this info helps.