So, if you have RA & are on Methotrexate, be rest assured that you are with the King. You are taking the world’s most trusted DMARD. For the newly diagnosed, someone may scare you that Methotrexate is a cancer medication. Yes it is; but in a very high dose as compared to that for RA. Just the way salt is used in many dishes, even drugs like Methotrexate are used in many different conditions. And, mind you, RA is akin to cancer. The swollen rogue synovium proliferates like a cancer tissue & eats up the cartilage & bones. Methotrexate works against these rogue cells, be it cancer or RA.