FYI: Plaquenil is in the cipro/Levaquin family

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New Member

Date Joined Aug 2017
Total Posts : 10
   Posted 8/27/2017 5:06 PM (GMT -6)   
I would like to say hello to all the lupies on this board. I just joined the forum. I just got dx in May, 2017 after having fibromyalgia for 20 years!

I was reading an old post re: plaquenil & horrible back/leg pain. I found out (the hard way) that plaquenil is in the quinolone family of antibotics! Double black box warnings! That antibotic made me go to the ER 3 times because I couldn't breathe, was having severe pain in my muscles. Achilles tendons were actually vibrating! I was sick for 3 months after that!

I started on Plaquenil at the low dose of 200. My left achilles tendon started to vibrate & go into spasms. I thought it was a lupus flare. I was sicker than a dog with vision problems, trembling hands, couldn't breathe, severe pains everywhere & couldn't walk. I was dependent on hubby for everything! I had just broke that leg 1 month before & thought it was healing. No it wasn't healing pain, it was the plaquenil! Thank goodness thru the fog I realized what the problem was. I still can't stand for to long, but slowly my legs are coming back.

Thought I would share my experience with this med. For me it was skull
Lesson learned: Watch out for side effects with any meds & if in doubt, call your doc!

(((((Gentle hugs)))))

Post Edited (lupieinzona) : 8/28/2017 8:33:50 AM (GMT-6)

Forum Moderator

Date Joined May 2005
Total Posts : 7468
   Posted 8/28/2017 12:54 PM (GMT -6)   
Hum. I can't find any evidence saying they are in the same family. There is some resemblance in the BRAND names, but not in the chemical names.

So, I don't know if they are in the same family or not, but I have had severe issues with Levaquin but I had ZERO issues with Plaquenil. None at all.

So if you are prescribed Plaquenil and know you have a Levaquin issue, I would discuss with the Dr and take it cautiously rather than just dismissing it totally wihtout testing your personal reaction.

Levaquin (levofloxacin) is an antibiotic that fights bacteria in the body.

Plaquenil (hydroxychloroquine sulfate) is a disease-modifying anti-rheumatic drug (DMARD) used with SLE and arthritis.
Lynnwood, Lupus & Sjogren's Moderator, Dx: 2000
"Life is far too important to be taken seriously." - Oscar Wilde

Post Edited (Lynnwood) : 8/28/2017 1:45:15 PM (GMT-6)

Veteran Member

Date Joined Mar 2007
Total Posts : 1615
   Posted 9/1/2017 6:37 PM (GMT -6)   
No, it is not in the flouroquinolone family. It has no flourine atom, which is a requirement for a FLOUROquinolone.

The flouroquinolone antibiotics are quinolones (note the "o" in the last syllable) with a flourine atom attached, among other things.

Plaquenil is a quinoline (note the "i" in the last syllable).

The quinolone/quinoline names mean they share a very similar, but not identical, core of two conjoined rings of carbon and nitrogen, but the bonds are different and the atoms attached to/around the rings are different.

You might say they are 'cousins,' but Plaquenil is not in the same family - it's in a related family.

The black box warnings for the flouroquinolones do NOT apply to Plaquenil.

Post Edited (beave) : 9/1/2017 6:40:59 PM (GMT-6)

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