No, it is not in the flouroquinolone family. It has no flourine atom, which is a requirement for a FLOUROquinolone.
The flouroquinolone antibiotics are quinolones (note the "o" in the last syllable) with a flourine atom attached, among other things.
Plaquenil is a quinoline (note the "i" in the last syllable).
The quinolone/quinoline names mean they share a very similar, but not identical, core of two conjoined rings of carbon and nitrogen, but the bonds are different and the atoms attached to/around the rings are different.
You might say they are 'cousins,' but Plaquenil is not in the same family - it's in a related family.
The black box warnings for the flouroquinolones do NOT apply to Plaquenil.
Post Edited (beave) : 9/1/2017 6:40:59 PM (GMT-6)