Difference between SED rate & C-reactive protein

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Regular Member

Date Joined Oct 2005
Total Posts : 251
   Posted 5/3/2007 10:30 AM (GMT -6)   
I know that both of these are inflammation tests, but what is the difference between them?  The reason I ask is because my SED rate was 16 (normal is 0-20), but my C-reactive protein was 13.2 (normal being 0.0-4.9).  I don't understand how one can be normal and the other high.  Someone enlighten me. :-)
Jeannie ~
   Mom to Ty (4 yrs old)
   and 3 Shelties
SLE diagnosis 10/05 now changed to RA 3/06, Endometriosis 5/05, PCOS 1990
Meds: Metformin ER 1500mg (PCOS); Loestrin BCPs (Endo); Methotrexate 17.5mg (RA); Metanx 5mg (RA); Remicade (RA); Lunesta 2mg (as needed)

Veteran Member

Date Joined Jan 2004
Total Posts : 4151
   Posted 5/3/2007 12:04 PM (GMT -6)   
That is strange. Both of mine were elevated last time... SED rate 30 and CRP at 20. I thought is was strange that my SED rate was slightly elevated and my CRP significantly elevated now that I think about it. I hope someone can shed some light on this.

Take Care
Co-Moderator ~ IBS Forum
Dx: IBS 1989, Diverticulosis 2004, Idiopathic Acute Colitis 2006, UCTD 2007
Meds: Plaquenil 400mg, Chlorzoxazone 500mg, Lyrica 50mg, Protonix 40mg, Naproxen 1000mg, Xanax XR 2mg, Miralax 17g, Supplements


Regular Member

Date Joined Oct 2006
Total Posts : 221
   Posted 5/3/2007 1:14 PM (GMT -6)   
My SED rate is always normal, but my CRP is always elevated. One of the reasons I am still in diagnosis limbo. My ANA is always sky high. I am anxious to hear what the others say on this one.....
Mother of four, full time Systems Analyst
Sjogrens, Crohns, suspected Lupus, Pancreatitis Dec. 2005
Meds:  Medrol injections; Darvocet, starting Plaquenil in Feb.

Regular Member

Date Joined Aug 2006
Total Posts : 142
   Posted 5/3/2007 4:55 PM (GMT -6)   
Hi everyone
Mine both are high sed rate around 50, and crp around 17.

Both of these tests measure general immflamation. There are no specific answers they can get from either beside that there is immflammation somewhere in the body.

A sed rate measures how long it takes for some sort of blood component to reach the bottom of a test tube. The longer it takes the higher the result. Because it measures blood components, and your blood pretty much replaces itself every 3 months this measure immflamation in the last 1-3 months. This is elevated for more chronic immflammation usually, like RA.

A c-reactive protein is a protein excreted from your liver. This test measures immflamation in the last 12 hours.....

So Jeannie your elevated CRP could simply be anything from cramps because of your period to a sore throat from allergies to the starts of a flare. But that is good that your sed rate is lower, it sounds like they may be on the right road to finding some pain relief if they havent all ready.

I hope all that made sense. Let me know if I can explain further!

Dx: UCTD,Raynaud's,iron deficientcy anemia
Rx: Multi-rec folic, Mobic, Plaquenil

Regular Member

Date Joined Aug 2006
Total Posts : 32
   Posted 5/5/2007 4:15 PM (GMT -6)   
Thanks for all of the info!  I was wondering what the difference was too.  When my blood was checked 3 wekks ago my sed rate was 63 and my CRP 20. 

Seronegative SLE '06 - IBD '06 - Kidney Involvement '07
Sulfasalazine, CellCept, Topamax, Elavil

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