Elevated GGT (liver test)

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dbab
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   Posted 5/22/2007 8:35 PM (GMT -7)   
Well I got my blood test results back from the Neuro today and saw that my GGT level is out of range. Nothing major I guess but elevated nonetheless. It's at 58 and the range from the lab shows normal 9-54. I did some searching and I found one reference that a woman's is elevated over 42 and the man's is elevated over 64 (or something like that). When I spoke with the nurse the other day, she didn't mention it when she went over my abnormal results.

I looked up the internet and it mostly says that this is elevated with alcohol consumption and alcoholism. Well I only have about one drink once a month, if that. I'm sure my Neuro who I told that I only drink on occasions must think that I lied sad Does anyone know if this can be elevated with Lupus or other connective tissue diseases or autoimmune diseases? My other liver tests were within normal range, this is the only one that was not. I'm wondering if I should even be worried about this or not.
"Des"
Co-Moderator ~ IBS Forum
Dx: IBS 1989, Diverticulosis 2004, Idiopathic Acute Colitis 2006, UCTD 2007
Meds: Plaquenil 400mg, Chlorzoxazone 500mg, Lyrica 50mg, Protonix 40mg, Naproxen 1000mg, Klonopin 2mg/day (tapering to PRN), Miralax 17g, Supplements


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mom46
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   Posted 5/23/2007 12:04 PM (GMT -7)   
Hi Des,
   Mine was elevated when I was taking Methotrexate years ago. My rheumy still checks it every 3 months because of the other meds I take. I see that you are on plaq...I'm not sure if that might cause it or not. Maybe someone else will know. I do know that alot of meds can elevate liver enzymes in some people.
   I hope you get some answers soon. Stay on your doctor about this. Hang in there and let us know what you find out. Take care and your in my thoughts and prayers.
                                                           (((Hugs))) Babs
  
 
 Lupus,RLS,RA,Asthma,Fibro,Sjogren's,Raynaud's,Divertic, Stroke,Atherosclerosis,Seizures,Sensory Polyneuropathy
Meds:Arava,plavix,aspirin,protonix,gabitril,zanaflex,xanax,
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dbab
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   Posted 5/23/2007 2:33 PM (GMT -7)   
Thanks Babs, You know I remember reading about it being elevated with NSAIDs sometimes so that may just be it. I don't take them daily anymore though so I can just imagine what it was like when I was taking two a day. I'll mention it to my rheumy when I go to my appt in July and see what he thinks. I did see also that GGT elevations can occur in SLE so thats another possibility. Just kind of scared me at first and I just started thinking the worse (like always).

Take Care
"Des"
Co-Moderator ~ IBS Forum
Dx: IBS 1989, Diverticulosis 2004, Idiopathic Acute Colitis 2006, UCTD 2007
Meds: Plaquenil 400mg, Chlorzoxazone 500mg, Lyrica 50mg, Protonix 40mg, Naproxen 1000mg, Klonopin 2mg/day (tapering to PRN), Miralax 17g, Supplements


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hippimom2
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   Posted 5/23/2007 6:21 PM (GMT -7)   
Des, I've had some elevated liver labs in the past, but not the one you are talking about. Hopefully you can get some answers from your doc about it when you have your next appointment. I agree with you that it's hard not to worry about anything that comes back abnormal, especially when it's dealing with one of your organs. I really hope it's nothing to worry about.

Hang in there and take care
Diagnosis:  UCTD (lupus) 2006; Raynauds 2006; Sjogren's 2006; lupus symptoms began 2003; CFS 1991; Mono 1985
Meds:  Plaquenil 400mg; Prednisone 5-10mg; Tramadol 100mg 3-4x daily; Amitriptyline 10mg; Neurontin 300mg; Prevacid; Steriod Cream and Mouth Rinse for tongue and mouth ulcers; Hydrocodone 5/500 prn for severe pain; Restasis eye drops

 

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Ginny
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   Posted 5/23/2007 8:25 PM (GMT -7)   

Hey Des,

Yeah, a lot of our meds are metabolized through the liver.  So an elevated GGT is usually expected.  Your number is barely above normal so don't worry.  My GGT lands in that area too. Although mine is now in the 70's.  Just got some results back today.  So I"m getting an ultrasound done to see if it's just a fatty liver issue or what is up.  Don't worry about your number though.  It's not out of wack at all.

Ginny


I can do anything through Jesus Christ who strengthens me.  I have learned in whatever state I am in, to be content.  Phillipians 4:11-13

33 years old. Diagnosed with lupus in 2000. Fibromyalgia, anti-phospholipid syndrome(stroke),Sjogren's, Raynaud's, seizure disorder, libman sach's endocarditis, vasculitis, sacroiliitis, Neutropenia, thrombocytopenia, possible early menopause - do diagnosis yet. Prednisone, Imuran, Coumidin, Clobazam, Amitriptyline, didrocal, monopril, calcium, Cykolokapron, multi-vitamin, vitamin D, Magnesium, vitamin B6, Acidophilus


cured4real?
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Date Joined Dec 2005
Total Posts : 1944
   Posted 5/23/2007 10:41 PM (GMT -7)   
Hi Des,
I've got severe fatty liver and have elevated liver levels at times. there is something called NAFLD--non-alcoholic fatty liver disease. The docs used to accuse everyone of being an alcoholic that had fatty liver, but now they know it can be caused by many things. Pre-diabetes--hyperinsulinemia or Metabolic syndrome x-- causes it from eating too many carbs. Also lyrica, NSAIDs and some of the other meds you are on can really hurt your liver. ALTs measure liver repair taking place, which then indicates damage, but I've often wondered what your liver levels look like if your liver is not repairing itself, it can still be being damaged. ALP is more of an indicator of serious liver disease and cancer. There IS TREATMENT FOR FATTY LIVER. Eliminating drugs hard on your liver, following a diabetic diet, losing weight, and some diabetes drugs like Metformin help your liver get rid of the fat. Most hepatologists don't know this so you need to push if this is your problem. Catching diabetes early can help. My guess would be a drug thing first, I'm not familiar with chlorzoxazone or protonix, but am with klonopin and take 1-2 regularly with no elevation. Plaquenil causes me no problems as it is primarily processed by kidneys. Taking drugs by patch or injection bypasses this part of the liver and for me doesn't cause the rise in levels, only pills and certain foods and obesity. You should get tested for autoimmune hepatitis and see a hepatologist if you can, not just a GI guy, but a real hepatologist, even just for one visit.

Here's what I got from labtestsonline
Elevated GGT levels indicate that something is going on with your liver but not specifically what. In general, the higher the level the greater the “insult” to your liver. Elevated levels may be due to liver disease, but they may also be due to congestive heart failure, alcohol consumption, and use of many prescription and non-prescription drugs including nonsteroidal anti-inflammatory drugs (NSAIDs), lipid-lowering drugs, antibiotics, histamine blockers (used to treat excess stomach acid production), antifungal agents, seizure control medications, antidepressants, and hormones such as testosterone. Oral contraceptives (birth control pills) and clofibrate can decrease GGT levels.
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Is there anything else I should know?
Even small amounts of alcohol within 24 hours of your GGT test may cause a temporary increase in the GGT. If this occurs, your doctor may want to repeat the test to verify that it is normal.

GGT levels fall after meals, so it is best to be tested when you have not eaten for at least 8 hours.

Smoking can also increase GGT.

Levels of GGT increase with age in women, but not in men, and are always somewhat higher in men than in women.

GGT is about twice as high in persons of African ancestry as in those of European ancestry.
Marji

"...brain, what is brain?"
--Kara, one of the "givers of pain and delight", aka woman of Sigma Draconis VI, "Spock's Brain" episode 56 season 3 of Star Trek--I'm not a trekkie but this one was funny!


okie
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Date Joined Dec 2006
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   Posted 5/24/2007 3:53 AM (GMT -7)   
Hi Des, I know I'm a slug for not answering right away. I have been in a awful "fog" that I can't seem to shake. I just wanted to say hi and I hope they get to the bottom of this for ya. The only thing I ever had come back weird with my liver and some count they did when I was in the hospital with pnemonia. when that cleared up so this the liver problem. I wonder if maybe it's a symptom of the lupus? Perhaps when you are having a flare or somthing? Heck I don't know. I just wanted to touch base and let ya know I havn't died or anything and that my prayers are with you and all of you wonderful people.

love ya
carol
God Bless
Carol
 
 Newly DX's Lupus.Possible CREST,COPD, high PB xanax,triam , vicodin.5x3, Evista for osteo,. oxygen Plaquanil800mil, . effexor. spiriva, xopenex. pred.10.mil.
 
Come ye, all that are weary and heavy laden, and I will give you rest!
 
 


dbab
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Date Joined Jan 2004
Total Posts : 4151
   Posted 5/24/2007 5:59 AM (GMT -7)   
Thanks hippi, ginny, Marji and Carol...

Thank you for all of the great information. I will look into it more. Looking at my tests again, I noticed that even though the ALT and AST were not out of range, they did double their numbers from the last time. I will ask my Neuro when I go back on 5/31 and I will also ask my rheumy when I see him in July. I am beginning to think more and more that its probably from the meds. So what do you do in that instance? Do you just live with the pain or let your liver fail? Tough decision. Is there any drug that I could take for the pain that would not do as much damage as the NSAIDs and Lyrica? These are questions, I need to write down and address with my docs.

Thanks again :-)
"Des"
Co-Moderator ~ IBS Forum
Dx: IBS 1989, Diverticulosis 2004, Idiopathic Acute Colitis 2006, UCTD 2007
Meds: Plaquenil 400mg, Chlorzoxazone 500mg, Lyrica 50mg, Protonix 40mg, Naproxen 1000mg, Klonopin 2mg/day (tapering to PRN), Miralax 17g, Supplements


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cured4real?
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Date Joined Dec 2005
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   Posted 5/24/2007 7:36 PM (GMT -7)   
Des--
I take Ultram for pain and can tolerate it because it mimics a narcotic and I can take narcotics because they are close to our body's own pain killers. I can't take complex molecules. A hepatologist explained to me that the liver is like a screen and if it is inflamed, swelled with fat, or scarred, it changes the size of the holes in the screen, either making medicine back up and be toxic or too much to pass through. You are right to be concerned about the doubling in normal range, my docs look at that too, when they look, for a steady climb. You might want to get your insulin tested to see if you might have that pre-diabetes thing that can cause fatty liver that alot of people have from being overweight or even just eating too many carbs. It made my liver levels skyrocket. There are dietary changes you can make and medicines like glucophage they give you. My blood sugar was always normal but my insulin very high and my cells were immune to it and I wasn't processing sugars well, prediabetes. Maybe you can get by on a lower dose and maybe upping another med that doesn't irritate your liver, if that is the cause. I take klonopin with no problem at a relatively low dose 2-5 mg. Another nerve medicine I was able to take occasionally was tizanidine, and I take the muscle relaxer soma so far so good, low doses on both. I rarely take the tizanadine, so I don't know about every day. It's strong. Also you might want to consider an ultrasound of the liver with the baby ultrasound machine thingy if you keep having problems. It can tell healthy tissue from fat, from scar, from infection pretty well and is not invasive. I hope you feel better and your docs listen to you and pay attention and that you can find a good solution. Liver problems are a drag and make you tired and have gi problems and you just don't need that on top of everything.
Marji

"...brain, what is brain?"
--Kara, one of the "givers of pain and delight", aka woman of Sigma Draconis VI, "Spock's Brain" episode 56 season 3 of Star Trek--I'm not a trekkie but this one was funny!


cured4real?
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Date Joined Dec 2005
Total Posts : 1944
   Posted 5/24/2007 7:36 PM (GMT -7)   
Des--
I take Ultram for pain and can tolerate it because it mimics a narcotic and I can take narcotics because they are close to our body's own pain killers. I can't take complex molecules. A hepatologist explained to me that the liver is like a screen and if it is inflamed, swelled with fat, or scarred, it changes the size of the holes in the screen, either making medicine back up and be toxic or too much to pass through. You are right to be concerned about the doubling in normal range, my docs look at that too, when they look, for a steady climb. You might want to get your insulin tested to see if you might have that pre-diabetes thing that can cause fatty liver that alot of people have from being overweight or even just eating too many carbs. It made my liver levels skyrocket. There are dietary changes you can make and medicines like glucophage they give you. My blood sugar was always normal but my insulin very high and my cells were immune to it and I wasn't processing sugars well, prediabetes. Maybe you can get by on a lower dose and maybe upping another med that doesn't irritate your liver, if that is the cause. I take klonopin with no problem at a relatively low dose 2-5 mg. Another nerve medicine I was able to take occasionally was tizanidine, and I take the muscle relaxer soma so far so good, low doses on both. I rarely take the tizanadine, so I don't know about every day. It's strong. Also you might want to consider an ultrasound of the liver with the baby ultrasound machine thingy if you keep having problems. It can tell healthy tissue from fat, from scar, from infection pretty well and is not invasive. I hope you feel better and your docs listen to you and pay attention and that you can find a good solution. Liver problems are a drag and make you tired and have gi problems and you just don't need that on top of everything.
Marji

"...brain, what is brain?"
--Kara, one of the "givers of pain and delight", aka woman of Sigma Draconis VI, "Spock's Brain" episode 56 season 3 of Star Trek--I'm not a trekkie but this one was funny!


dbab
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Date Joined Jan 2004
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   Posted 5/25/2007 8:46 AM (GMT -7)   
Thanks Marji... Is the test for insulin a specific test? Yes, my glucose levels are always good and I had no idea there was a specific test for insulin. Everything happening to me is going downhill, my bp also which has always been good (never was over 120/80) is now around 134/90 which is significant. I slipped and fell at a restaurant a couple of weeks ago onto my knee and at the hospital my bp was 146/94, I cringed and I knew immediately that wasn't good. They said it was from the pain and trauma to my knee (no fractures, just contusion and swelling). Well my knee is better and my bp is still a bit high. When it rains it pours. I'm now starting to think that all of this (even the GGT levels) could be related to my heart and that scares the bejeebees out of me. My GP wanted me to see a cardio about my shortness of breath (don't know if you guys remember) and I never did... tsk tsk. I think that I need to bite the bullet and just do it. I just hate it cause I'm scared they will tell me bad news.
"Des"
Co-Moderator ~ IBS Forum
Dx: IBS 1989, Diverticulosis 2004, Idiopathic Acute Colitis 2006, UCTD 2007
Meds: Plaquenil 400mg, Chlorzoxazone 500mg, Lyrica 50mg, Protonix 40mg, Naproxen 1000mg, Klonopin 2mg/day (tapering to PRN), Miralax 17g, Supplements


http://www.healingwell.com/donate


cured4real?
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Date Joined Dec 2005
Total Posts : 1944
   Posted 5/25/2007 9:41 PM (GMT -7)   
Sorry to hear about your fall, knees are bad too, have a habit of turning into water on the knee and junk. I hope you are ok. Tiger Balm helps my bruises alot, it's really strong camphor and it seems to help me for some reason. Yes, there is a specific blood test for insulin and docs do not regularly do it, though I don't know why since most of their patients are overweight and have bp problems and family hx of diabetes.

My bp started going up when I had hyperinsulinemia and has come down since I started taking glucophage. When you are "prediabetic" you can be "low blood sugar" or hypoglycemic--which docs usually call normal for some strange reason because it doesn't feel normal--and hyperglycemic or "high blood sugar", which they treat. I am both, depending on what I eat and when.

If you can afford it, you might want to invest in a blood sugar meter, you don't need a prescription and a lot of dieters get them, they aren't bad to have around. After you eat dinner, you do a test and see how the food affected you, and you can test first thing in the morning to see how low you are. You can see how much it jumps around--it should be consistent--mine is consistent 100--because your body should be adjusting.

Anyway, if your insulin is really high it usually means you are hypoglycemic at times and your cells may be immune to insulin, so your pancreas is burning out trying to make the enormous amount of insulin you need to try to process sugar, and sugar in the form of fat accumulates in your liver.

The doc can and should do a glucose tolerance test, which is the only TRUE way to see if you are diabetic, no matter what they say, research will confirm this. You have to fast and they give you this high glucose stuff, really sweet. My sugar shot up to 180 (normal range is 80-120) within an half hour of drinking it and I don't know how high it went. This from Miss Normal blood sugar.

I also think some people, people with AI disease?, are more sensitive to small changes in blood sugar. I feel best at 100, 80 or under and I get shakey and panicky --they kept telling me I had panic disorder. Over 120 and I can feel panicky too, or sleepy and not well. It depends. Anyway, caught early, this is a fixable preventable problem and you don't have to develop diabetes, though it seems a lot of people do anyway. I can tolerate sugar much better now that I don't eat it as much, my bp is always normal now and I don't have to take bp medicine and I've lost some weight and my liver should be getting better. Not a bad tradeoff.

Diabetes is one of those things like thyroid, it causes all kinds of problems that seem unrelated. It's an awful disease and I really learned to have so much sympathy for all the older people who have it because full blown it can really be a drag in so many ways. Its kind of my personal thing to try to get people to get checked for prediabetes, especially if they are overweight, because so many docs just see the blood pressure going up and put you on bp meds with doing a glucose tolerance test, and then if your sugar drops for some reason, your bp drops dangerously low and you can end up in the hospital, so its my soapbox.

I have shortness of breath and it's because I have asthma, also I don't know if you have allergies. Shortness of breath was also the key feature of my liver disease, especially climbing stairs, my old professors were passing me by and I was huffing and puffing, ready to pass out. I still am too short of breath to take a regular stress test, but I have asthma/chronic bronchitis/COPD due to scarring of my bronchial tubes probably from all the pneumonia I had and histamine problems from my liver and AI disease. I think the true origin of asthma is in the liver, if I remember correctly. I should look that up. Oh, if you take a pen with the cap on it and draw a line on your arm and it turns red, that's a sign your histamines are high. they do that to me a lot,theres even a name for that test, its a real test you can do yourself. BTW, antihistamines don't help most stuff usually because they only work on certain histamines.

Seeing the cardiologist is good and you shouldn't be afraid. I had some damage because I have those anticardiolipin antibodies and got some atrophy of one side of my heart but once I went on plaquinil and steroids and it healed up. It can heal up, even if you have some damage. I thought that was great. I was sure my heart was bad, but it was the one good thing! The heart seems to be able to take a lot. So don't worry, just go.

It's probably asthma from the liver stress (histamines). Have they done any pulmonology tests for asthma? Do you use an inhaler?

Sorry so long. I'm hoping it's something simple that maybe a med vacation and dietary change (maybe major though) will fix and I hope you feel better soon. Will pray and send good wishes your way.
Marji

"...brain, what is brain?"
--Kara, one of the "givers of pain and delight", aka woman of Sigma Draconis VI, "Spock's Brain" episode 56 season 3 of Star Trek--I'm not a trekkie but this one was funny!


HAPPYFEET
New Member


Date Joined May 2007
Total Posts : 6
   Posted 5/31/2007 1:52 PM (GMT -7)   
Hi,
 
yes your liver enzeymes can be elevated with autoimmune diseases when i first became ill in jan 07 my liver was elevated 124 i believe, never had any abnormals before, the muscular distrophy doctor explained to me when your CK's are elevated your liver will also be elevated he stated to me they still don't know why this happens. I'm sorry Ck's are muscle enzeymes and also with any other abnormal labs that have to do with autoimmune diseases. my liver is still slightly elevated but not as high.
the doctors told me not to worry, so i should i worry yeah i'm sure if they felt like we do they would worry...
well God Bless you
Happy feet.

Maile
New Member


Date Joined Apr 2008
Total Posts : 8
   Posted 4/27/2008 10:42 AM (GMT -7)   
Hi folks.  I do not know if this is the place, but my liver results showed a 48 AST..and 43 is normal.  My dr first said I was normal and then remembered that I drink wine.She told me I should absolutely cut out alcohol.  Now I did the fast correctly before the test and know I had too much wine..before it.  Do you think I need to cut it all out or just return to a glass?  Any ideas?  Also I am overweight so I am wondering if that is a factor.

mom46
Veteran Member


Date Joined Dec 2004
Total Posts : 8198
   Posted 4/28/2008 11:55 AM (GMT -7)   
Hi Maile,
   Welcome to the forum. You didn't say what disease your being treated for or what meds your are taking that might cause your AST to be elevated. I think you should take your doctors advice since he/she probably had a good reason to tell you to cut out alcohol.
   I hope you will post again soon and tell us more about yourself. You will meet some wonderful caring people here. Take care and please keep us updated. You will be in my prayers.
                                                               Babs
 
Dx: Lupus,RLS,RA,Asthma,Fibro,Sjogren's,Raynaud's,Divertic, Stroke,Atherosclerosis,Seizures,Neuropathy,CAD
Meds:arava,prednisone,plavix,aspirin,protonix,,zanaflex,xanax,
mirapex,advair,foxamax,Vytorin,folicacid,lunesta,Tramadol
 
JOB 5:18 For he wounds, but he also binds up; he injures, but his hands also heal.


Maile
New Member


Date Joined Apr 2008
Total Posts : 8
   Posted 4/28/2008 8:13 PM (GMT -7)   

Thanks Babs for your caring response.  I am being treated for high blood pressure and low thyroid.  Those are my only meds.  Plus I am overweight and have lost 30 pounds..but have 50-70 to lose.

You are right..but I am fighting giving up the wine..Of course it makes me realize that the addiction is strong.

How is your health?  I hope you are feeling well today.


mom46
Veteran Member


Date Joined Dec 2004
Total Posts : 8198
   Posted 4/29/2008 12:20 PM (GMT -7)   
Hi Maile,
   It sounds like you are having a rough time....((Hugs)). Let your doctor know that you are having problems with giving up the alcohol. He should be able to prescribe something to take the edge off and help you stop.
   I'm doing pretty good, thanks for asking.
   I wish you the best with this. I'm sure it will be hard, but you can do it. Please keep us updated and take care. You will be in my thoughts and prayers.
                                                         Babs
 
Dx: Lupus,RLS,RA,Asthma,Fibro,Sjogren's,Raynaud's,Divertic, Stroke,Atherosclerosis,Seizures,Neuropathy,CAD
Meds:arava,prednisone,plavix,aspirin,protonix,,zanaflex,xanax,
mirapex,advair,foxamax,Vytorin,folicacid,lunesta,Tramadol
 
JOB 5:18 For he wounds, but he also binds up; he injures, but his hands also heal.


redrose77
Veteran Member


Date Joined Sep 2005
Total Posts : 2573
   Posted 4/29/2008 12:40 PM (GMT -7)   
Des, I take imuran in large part because it keeps my liver tests in the normal range. Within a 2 weeks of starting it my liver enzymes began dropping and were normal in less than 2 months. If I stop for any length of time they begin to rise again. Liver involvement is one of those super rare but extremely dangerous symptoms. I hope you get your liver enzyme oddness cleared up.
Dx:fibromyalgia 2002, systematic lupus 2005- definate CNS involvement dxed late 2005, psoriasis 2006, rheumatoid arthritis 2006, PTSD 2007, multiple allergies 2005, migraine, compression fractures T11 & T12, Sjögren's, damaged periphrial nerves 2007, pregnant due May 2008
Tx: plaquenil, Enbrel, Darvocet, Singulair, Flexeril, Baby Asprin, Imuran, Procardia, Prilosec


apres
New Member


Date Joined Jun 2009
Total Posts : 1
   Posted 6/12/2009 5:38 PM (GMT -7)   
Okay, I am totally freaking out. I got a full physical last week and knew I drink more alcohol than the average person but when I got my blood panel back today I was totally shocked. My GGT level is more than 600!! I am 5'8" weigh 124 pounds, work out 4-5 times a week and eat well. I do take quite a lot of vitamins and am on topamax and zanax and ambien. I was on antibiotics when I got the test, can that elevate the level? I am going back to my physician next week for a follow up but have been looking up levels all afternoon and they are severly high. She told me on the phone there was some type of IV that they have that you can take once a week that would help lower, have you heard of that? Just looking for answers anywhere...
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