Rheumatoid factor positive then negative

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Veteran Member

Date Joined Dec 2005
Total Posts : 1944
   Posted 7/17/2007 3:44 PM (GMT -6)   
I was tested for Rheumatoid factor and it came out positive a few years ago and then I was retested a month or so later and it was negative.  My primary said this means I don't have RA. But can it go positive and then negative if you have RA or is it always positive?  I forgot to bring this up with the rheumy, brain not working well these days.
Love, Marji
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Veteran Member

Date Joined Jan 2004
Total Posts : 4151
   Posted 7/17/2007 3:58 PM (GMT -6)   
I don't know much about it going positive to negative or the other way. I'm sure its possible because many tests do, especially with Lupus type of tests. I think I read though that only about 70% of people with RA test positive for the rheumatoid factor so I'm not sure how your doc is ruling it out completely especially since it was positive at one point. I would definitely tell your rheumy the next time you see him, he would have more experience with this test than the primary. Good luck.

Take Care
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Veteran Member

Date Joined Jul 2005
Total Posts : 5403
   Posted 7/17/2007 6:03 PM (GMT -6)   
marji, I had a similar experience. A few years ago my rheumatoid factor was just barely positive (one point over), so the rheumy didn't pay much attention to it anyway. Then about 6 months later it was re-tested during a flare and was negative. I really didn't ask about it since no one paid much attention to the first one anyway. I agree with Des that I'm guessing a lot of these labs fluctuate. Definitely ask about again when you see your rheumy. Of course none of this can be easy or clear cut.

Take care
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