CPK isoenzymes test

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Juliaa
Regular Member


Date Joined Feb 2006
Total Posts : 131
   Posted 7/21/2007 12:40 PM (GMT -7)   
Hello everyone, I was wondering has anyone has had a CPK test; and if your results were high. I'm really curious what it means in autoimmune issues such as lupus.  

(A CPK is a blood test that measures creatine phosphokinase (CPK), an enzyme found mainly in the heart, brain, and skeletal muscle.)

 I know it can be an indicator of a heart attack, and thats all I really know.  Any information would be greatly appriciated.  Thank you all and have a wonderful day. 
DX:  Migraine; SLE; Diverticulitis;HB;neuropathy seizures; Sjogrens
 
Micardis, plaquenil,Prednisone, anti seziure drug, & Nsaids


Lynnwood
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Date Joined May 2005
Total Posts : 7019
   Posted 7/21/2007 1:06 PM (GMT -7)   
Just to let you know I read your post! Unfortunately, I've never had that test and don't know anything about it, so I'm not of much help.

More than likely someone will be along soon that can help you out...sometimes we have less activity on weekends than during the week, but I'm sure someone knows!

Lynnwood, Co-Moderator: Lupus Forum
SLE(’00), Sjogren's Syndrome, Raynaud's Syndrome, SAD, Depression, Herpes Simplex 1
Piroxicam, Plaquenil, Cellcept, Prednisone, Xanax, Trazodone, Fosamax, Wellbrutrin SR, Valtrex
Click: DIAGNOSING LUPUS (4 of 11), LUPUS INFORMATION, LUPUS RESOURCES, Donate to HealingWell, Drug Interactions


Juliaa
Regular Member


Date Joined Feb 2006
Total Posts : 131
   Posted 7/21/2007 2:52 PM (GMT -7)   
Thanks Lynnwood, Have a great week end.
DX:  Migraine; SLE; Diverticulitis;HB;neuropathy seizures; Sjogrens
 
Micardis, plaquenil,Prednisone, anti seziure drug, & Nsaids


MJLD
Veteran Member


Date Joined Jul 2007
Total Posts : 1048
   Posted 7/21/2007 4:27 PM (GMT -7)   
Julia,
I know the main thing a cpk is usually checked for is heart attack. I see where you listed neuropathy seizures on your diagnosis; central nervous system trauma and convulsions can also cause an elevated cpk. If it was suspected that you had a heart attack there are other levels that are more reliable indicators and are checked in conjunction with the cpk; such as the troponin level. I wish I had more info to offer. Let us know what you find out. God Bless,
Judy

Juliaa
Regular Member


Date Joined Feb 2006
Total Posts : 131
   Posted 7/21/2007 5:34 PM (GMT -7)   
Thanks so much Judy, I didn't realize that my seizures could have anything to do with my test reading. They ordered a retest, I should find out those results this week. I do have the chest pain which has been attributed to lupus, my GP and Rheumy seemed concerned about the test and muscle atrophy, not a heart attack, ( thank goodness) but really didn't explain much. They told me to have another round of tests. Two perscriptions full, and so many tests that when I got home from the lab, they called me back to draw more blood. They ran out. That made me laugh. Never had them take too little before. Thanx for the info and have a blessed day. Julia
DX:  Migraine; SLE; Diverticulitis;HB;neuropathy seizures; Sjogrens
 
Micardis, plaquenil,Prednisone, anti seziure drug, & Nsaids


Butterflake
Forum Moderator


Date Joined Jun 2006
Total Posts : 1547
   Posted 7/21/2007 5:52 PM (GMT -7)   
Hi Julia.  You're right about what CPK measures, but an important use of CPK is to measure muscle damage.  Like you said, heart (a muscle), skeletal muscle.  So if you have diseases like polymyositis or muscular dystrophy, you will have a highly elevated CPk.  I'm having bad brain fog right now, so that's all I can remember, but I hope it helps.  
Dx: SLE diagnosed 2005, major depressive disorder, diabetes, fibromyalgia, gerd, sleep apnea, hypertension, IBS
Tx: plaquenil, methotrexate, Imuran, prednisone 10mg, flexeril, prozac,  celebrex, lisinopril, actos, lipitor, nexeum, seroquel, arthritis tylenol  PRN: ambien, neurontin, promethazine, xanax
supplements: multi vitamin, C, flaxseed oil, calcium/D
             Better living through chemistry :D    Donna
 


Bsime
Veteran Member


Date Joined Apr 2006
Total Posts : 1298
   Posted 7/21/2007 9:03 PM (GMT -7)   
Julia,
 
CPK tests are used for many reasons to diagnose muscle and brain tissue breakdown.  There is a class of auto immune diseases called myositis (polymyositis, dermatomyositis, and inclusion body myositis) that are inflammatory muscle diseases.  When the disease is active it is breaking down your skeletal muscle cells and your cpk number can be significantly elevated.  Normal range is considered 45-225 but patients with an active myositis disease can have readings of 10000 or even many times that.
 
I have polymyositis and had a reading of 13000 at the worst.  CPK readings are not always an accurate indication of how bad the disease is or how much damage is being done but it is one measure.  People who work out with weights or those who run marathons or triathelons can temporarily register very high numbers.
 
Lupus can attack your muscles as well but I don't think that you will register such high cpk readings as someone with myositis.
 
Some people have overlapping connective tissue diseases like I do.  Mine is called mixed connective tissue disease and is a three-fer:  lupus, scleroderma and polymyositis.  Lots of fun and very rare.  Some have undifferentiated connective tissue disease which is often just a transition to a specific diagnosis and also involved having symptoms of several AI diseases. 
 
Bill
Mixed connective tissue disease (systemic lupus, scleroderma, polymyositis), Raynauds phenomena, Hypertension, Barrett's esophagus.
 
Meds: prednisone (7mg & tapering), 100mg imuran, lisinopril 40mg, maxide 37.5/25mg, norvasc 5 mg, folic acid, potassium, aciphex 20mg, multi vitamins.
 
Maintain your optimism and you can beat the odds.
 
"Although the world is full of suffering, it is also full of the overcoming of it."  Helen Keller
 
 


Juliaa
Regular Member


Date Joined Feb 2006
Total Posts : 131
   Posted 7/22/2007 5:51 AM (GMT -7)   
Thank you very much for the information Donna & Bill-God Bless

Julia
DX:  Migraine; SLE; Diverticulitis;HB;neuropathy seizures; Sjogrens
 
Micardis, plaquenil,Prednisone, anti seziure drug, & Nsaids


cured4real?
Veteran Member


Date Joined Dec 2005
Total Posts : 1944
   Posted 7/22/2007 7:41 PM (GMT -7)   
Hi--
I had mildly elevated CPK with chest pains and irregular EKG and had atrophy of the heart due to anitibodies to it and it was made worse by a medication I was on. When they got it under control, I was OK and the atrophy did heal and go away, though my heartbeat is still irregular. That's all I know about it. They said I had a heart attack, but a mild one, I went to the ER right away.
Love, Marji
--Doctors are men who prescribe medicines of which they know little, to cure diseases of which they know less in human beings of whom they know nothing.--Voltaire (1694-1778)
Ills--Sjogrens-Lupus-like AI Disease, Hashis, Vitiligo, spinal stenosis/fusion with plate, salivary/lymphectomies, Diabetes, NAFLD, COPD, RLS, neuropathy, trigonitis, hystero, diffuse brain atrophy
Meds--Plaquenil, Evoxac, Metformin, Synthroid, HCTZ, Estradiol patch, Prosed, Klonopin, Soma, Ultram, Vicodin, Restasis, Albuterol,steroid injections, Protopic & Triamcinolone Acetonide ointments


Juliaa
Regular Member


Date Joined Feb 2006
Total Posts : 131
   Posted 7/23/2007 3:24 PM (GMT -7)   
Wow Marji, I'm glad your okay & everyone else too. It seems that this test has many meanings and out comes. I will ask when I go on Wed. for a through explaination on the test and if it has anything to do with my particular health issues. Thanks for the information & gald your feeling better.
God Bless

Julia
DX:  Migraine; SLE; Diverticulitis;HB;neuropathy seizures; Sjogrens
 
Micardis, plaquenil,Prednisone, anti seziure drug, & Nsaids

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