Hi...first visit to this site. I have sle ....also lupus nephritis (proliferative glomuero..something..something!!!) I have suffer off and on with large amounts of blood and spilling protien in urine. Mine is due to extensive kidney damage from lupus.
I've had several biopsies and have to do 24 hour urines every so often to calculate the amounts of blood and protien.
I've also had several joint replacements due to damage from prednisone use. Anyone else had to go through several replacements? I've had 8 hips and 5 wrist and so far have not anyone who has had to go through so many and am wondering .....what the heck happened with me and the prednisone!!!
I am now 48 and got my confirmed diagnosis at age 15.
thanks for reading this and any info would be good!!!
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Focal proliferative mesangiopathic glomerulonephritis is a form of lupus nephritis. It is characterized by large amounts of protein passing through the glomeruli (tiny filters) which damages the glomeruli and becomes a vicious cycle. It doesn't "target" the joints; however, chronic kidney disease can cause calcium imbalances and coupled with the fact that the first line treatment is steroids; it can wreak havoc on the bones. I know when I first went into kidney failure I was given 1000mg of solumedrol i.v for 5 days followed by 120mg of prednisone by mouth for many weeks. It was rough! It took me 13 months to come off the steroids that first time. If you do a search on mesangiopathic glomerulonephritis and the nephrotic syndrone you'll get a better picture. My last biopsy showed a progression to global glomerulosclerosis.
Gypsy...i'm baffled by the number of joint replacements you've had. Are you having infections that are causing the joints to have to be replaced? I know the prednisone impairs your ability to heal and suppresses your immune system. I'm sorry you've had such an ordeal. God Bless,